Results 171 to 180 of about 24,159 (244)

Pharmacokinetic Changes of Ceftazidime-Avibactam with Veno-Arterial Extracorporeal Membrane Oxygenation in a Critically Ill Patient with Severe Renal Impairment: A Case Report. [PDF]

Infect Drug Resist
Shen Z, Qin H, Li Q, Mao X.
europepmc   +1 more source

Structure and Mechanism of PhdC, a Prenylated‐Flavin Maturase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 5, Page 1019-1029, May 2026.
ABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Dominic R. Whittall, Henry G. Box, Karl A. P. Payne, Stephen A. Marshall, David Leys   +4 more
wiley   +1 more source

Gabapentin CNS exposure and analgesic response are modulated by OCT2 genotype in patients with chronic neuropathic pain. [PDF]

Front Pharmacol
Zhou L, Yamamoto PA, Walker M, Conchon Costa AC, Lauretti GR, Dach F, Schmidt S, de Moraes NV.   +7 more
europepmc   +1 more source

Intestinal Organoid‐Based Mathematical Modeling Predicts Clinical Gastrointestinal Toxicity of Oral Oncology Drugs

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Gastrointestinal (GI) toxicity is a common and potentially severe side effect of antiproliferative cancer therapies that often requires dose reduction or treatment interruption. Despite the clinical implications, there are currently no robust strategies for quantitative preclinical assessment of GI toxicity.
Carmen Pin, Deepa Maheshvare M., Louis Gall, Andrew Hall, Muireann Coen, Ambra Bianco, Shimeng Liu, Kenneth Pryde   +7 more
wiley   +1 more source

A simple and reliable method for the qualitative and quantitative analysis of nano- and microplastics in organs for controlled preclinical studies. [PDF]

Part Fibre Toxicol
Jeon S, Kim G, Jeon JH, Yang SI, Lee K, Park JW, Cho WS.   +6 more
europepmc   +1 more source

A Unified Framework for Statistical Inference and Power Analysis of Single and Comparative Fβ$$ {F}_{\beta } $$ Scores

Statistics in Medicine, Volume 45, Issue 10-12, May 2026.
ABSTRACT Machine learning and artificial intelligence are increasingly applied to medical diagnostics and clinical decision‐making. To evaluate model performance, the F1$$ {F}_1 $$ score and its generalized form, the Fβ$$ {F}_{\beta } $$ score, are widely used as they balance precision and sensitivity.
Chih‐Yuan Hsu, Qi Liu, Yu Shyr
wiley   +1 more source

Antimicrobial peptides isolated from probiotics as an alternative to antibiotics against <i>Salmonella</i> infection. [PDF]

Appl Environ Microbiol
Bhandari M, Lokesh D, Thenissery A, Shrestha R, Rajashekara G.   +4 more
europepmc   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2324-2340, May 2026.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Evidentiary Standards for Newly Approved Antibiotics for Uncomplicated Urinary Tract Infections. [PDF]

Antibiotics (Basel)
Rodriguez-Monguio R, Seoane-Vazquez E, Powers JH.   +2 more
europepmc   +1 more source

Far, Moderate or in Between? The Ties That Shape Canadian Right‐Wing Youth Activism

Canadian Review of Sociology/Revue canadienne de sociologie, Volume 63, Issue 2, May 2026.
ABSTRACT Canadian right‐wing youth social movement actors are not a monolith. In this paper, I analyze 45 interviews and notes from a year of ethnographic fieldwork with a population of Canadian right‐wing youth activists between 2023 and 2024. While these youth activists are part of the same right‐wing organizations, some espouse far‐right ideas ...
Kayla Preston
wiley   +1 more source