Results 201 to 210 of about 544,008 (293)

Microfluidic Biochip‐Based Multiplexed Profiling of Small Extracellular Vesicles Proteins Integrated with Machine Learning for Early Disease Diagnosis

Advanced Science, EarlyView.
This study develops a diagnostic platform for early detection of esophageal squamous cell carcinoma (ESCC) by integrating a barcode immunoassay biochip with machine learning. The biochip captures and analyzes small extracellular vesicle proteins from serum samples, identifying nine biomarkers linked to ESCC.
Xue Zhang, Yibin Jia, Zhikai Li, Yunhong Zhang, Chao Wang, Yanbo Liang, Jiaoyan Qiu, Mingyuan Sun, Xiaoshuang Chen, Miao Huang, Yu Zhang, Jianbo Wang, Hong Liu, Chuanbin Mao, Lin Han   +14 more
wiley   +1 more source

Inferring gene-pathway associations from consolidated transcriptome datasets: an interactive gene network explorer for <i>Tetrahymena thermophila</i>. [PDF]

NAR Genom Bioinform
Bertagna MA, Bright LJ, Ye F, Jiang YY, Sarkar D, Pradhan A, Kumar S, Gao S, Turkewitz AP, Tsypin LMZ.   +9 more
europepmc   +1 more source

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

Advanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal, Minal Nenwani, Ishaque Pulikkal Kadamberi, Sudhir Kumar, Olamide Animasahun, Jasmine George, Shirng‐Wern Tsaih, Prachi Gupta, Mona Singh, Anjali Geethadevi, Chandrima Dey, Noah Meurs, Ajay Shankaran, Pradeep Chaluvally Raghavan, Deepak Nagrath, Sunila Pradeep   +15 more
wiley   +1 more source

Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep

Advanced Science, EarlyView.
The Hu sheep diverged from the Small‐tailed Han sheep ≈1330 years ago, and subsequently migrated from northern to warm and humid southern regions. The genes BMPR1B, UNC5C, and GRID2 play a synergistic role in the superior reproductive traits of Hu sheep.
Zexuan Liu, Na Zhang, Zilong Wen, Haitao Wang, Tingting Li, Runlin Ma, Menghua Li, Daxiang Wang, Haiping Shu, Xun Huang, Jianlin Han, Yiqiang Zhao, Qiuyue Liu   +12 more
wiley   +1 more source

Bioinformatic Analysis and Molecular Docking Identify Isorhamnetin Is a Candidate Compound in the Treatment of Pulmonary Artery Hypertension. [PDF]

Anatol J Cardiol
Shao C, Xia W, Liu Y.
europepmc   +1 more source

ASO Therapy Targeting STAU2 to Inhibit Pancreatic Ductal Adenocarcinoma Progression and Metastasis by Regulating the PALLD‐Mediated EMT Signaling Pathway

Advanced Science, EarlyView.
This study identifies STAU2 as an oncogenic RNA‐binding protein (RBP) with elevated expression in pancreatic ductal adenocarcinoma (PDAC), where its high levels are significantly correlated with metastatic progression. It elucidates that STAU2 directly binds and regulates PALLD, while mediating the functional role of IQGAP1, thereby driving metastasis ...
Jiayu Ding, Hao Shen, Jiaying Ji, Jiaxing Li, Zhongrui Shi, Xuejiao Wang, Bangbang Li, Yi Hou, Wenjian Min, Chengliang Sun, Kai Yuan, Yasheng Zhu, Liping Wang, Shun‐Qing Liang, Wenbin Kuang, Xiao Wang, Peng Yang   +16 more
wiley   +1 more source

Time-course liver microarray data from 0 to 14 days in a 70% partial hepatectomy mouse model. [PDF]

Sci Data
Nishi T, Oki Y, Hagiwara R, Kano K.
europepmc   +1 more source

Evaluation of the Performance of a p53 Sequencing Microarray Chip Using 140 Previously Sequenced Bladder Tumor Samples

, 2000
Friedrik P. Wikman, Ming-Lan Lu, Thomas Thykjær, S.H. Olesen, Lars Dyrskjøt, Carlos Cordon‐Cardo, Torben F. Ørntoft   +6 more
openalex   +1 more source

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors

Advanced Science, EarlyView.
This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang, Ting Wang, Yan Wang, Zeng Ye, Borui Li, Xuan Pan, Zheng Li, Guixiong Fan, Desheng Jing, Junfeng Xu, Qiangsheng Hu, Shunrong Ji, Xiaowu Xu, Xianjun Yu, Yi Qin   +14 more
wiley   +1 more source

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source