Results 61 to 70 of about 724,095 (330)

Differential expression of microRNA-206 and its target genes in pre-eclampsia [PDF]

, 2015
Objectives: Pre-eclampsia is a multi-system disease that significantly contributes to maternal and fetal morbidity and mortality. In this study, we used a non-biased microarray approach to identify novel circulating miRNAs in maternal plasma that may be ...
Akehurst, Christine, Beattie, Wendy, Brown, Catriona E., Carty, David M., Delles, Christian, Forrest, Rachel, Freeman, Dilys J., McBride, Martin W., McClure, John D., Robinson, Scott W., Sharafetdinova, Liliia, Small, Heather, Work, Lorraine M.   +12 more
core   +1 more source

Beyond Microarrays [PDF]

Science Signaling, 2008
Studies of global changes in mRNA abundance may be less than insightful.
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Gene Expression Studies to Identify Significant Genes in AR, MTOR, MAPK Pathways and their Overlapping Regulatory Role in Prostate Cancer

Journal of Integrative Bioinformatics, 2019
Gene expression studies revealed a large degree of variability in gene expression patterns particularly in tissues even in genetically identical individuals. It helps to reveal the components majorly fluctuating during the disease condition.
Asati Nimisha, Mishra Abhinav, Shukla Ankita, Singh Tiratha Raj   +3 more
doaj   +1 more source

Microarray-based Identification of Novel Biomarkers in Asthma

Allergology International, 2006
Bronchial asthma is a complicated and diverse disorder affected by genetic and environmental factors. It is widely accepted that it is a Th2-type inflammation originating in lung and caused by inhalation of ubiquitous allergens.
Kenji Izuhara, Hirohisa Saito
doaj   +1 more source

Identifying the Salient Genes in Microarray Data: A Novel Game Theoretic Model for the Co-Expression Network

Diagnostics, 2020
Microarray techniques are used to generate a large amount of information on gene expression. This information can be statistically processed and analyzed to identify the genes useful for the diagnosis and prognosis of genetic diseases.
Papori Neog Bora, Vishwa Jyoti Baruah, Surajit Borkotokey, Loyimee Gogoi, Priyakshi Mahanta, Ankumon Sarmah, Rajnish Kumar, Stefano Moretti   +7 more
doaj   +1 more source

Nucleic acid - protein fingerprints. Novel protein classification based on nucleic acid - protein recognition [PDF]

, 2012
Protein chemistry uses protein description and classification based on molecular mass and isoelectric point as general features. Enzymes are also compared by enzymatic reaction constants, namely Km and kcat values. Proteins are also studied by binding to
Alexander Krylov, Renad Zhdanov
core   +1 more source

Transcriptomic effects of the non-steroidal anti-inflammatory drug Ibuprofen in the marine bivalve Mytilus galloprovincialis Lam [PDF]

, 2016
The transcriptomic effects of Ibuprofen (IBU) in the digestive gland tissue of Mytilus galloprovincialis Lam. specimens exposed at low environmental concentrations (250 ng L-1) are presented. Using a 1.7 K feature cDNA microarray along with linear models
Amorim, Monica J. B., Bebianno, Maria João, Dondero, Francesco, Maria, Vera L.   +3 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Evaluation of chronic lymphocytic leukemia by oligonucleotide-based microarray analysis uncovers novel aberrations not detected by FISH or cytogenetic analysis

Molecular Cytogenetics, 2011
Background Cytogenetic evaluation is a key component of the diagnosis and prognosis of chronic lymphocytic leukemia (CLL). We performed oligonucleotide-based comparative genomic hybridization microarray analysis on 34 samples with CLL and known abnormal ...
Kolquist Kathryn A, Schultz Roger A, Slovak Marilyn L, McDaniel Lisa D, Brown Theresa C, Tubbs Raymond R, Cook James R, Theil Karl S, Cawich Victoria, Valentin Caitlin, Minier Sara, Neill Nicholas J, Byerly Steve, Morton S, Sahoo Trilochan, Ballif Blake C, Shaffer Lisa G   +16 more
doaj   +1 more source