Results 41 to 50 of about 883,556 (350)

Combining bioinformatics and machine learning to identify common mechanisms and biomarkers of chronic obstructive pulmonary disease and atrial fibrillation

Frontiers in Cardiovascular Medicine, 2023
BackgroundPatients with chronic obstructive pulmonary disease (COPD) often present with atrial fibrillation (AF), but the common pathophysiological mechanisms between the two are unclear.
Ziyi Sun, Ziyi Sun, Jianguo Lin, Jianguo Lin, Tianya Zhang, Xiaoning Sun, Xiaoning Sun, Tianlin Wang, Tianlin Wang, Jinlong Duan, Kuiwu Yao, Kuiwu Yao   +11 more
doaj   +1 more source

Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies.

American Journal of Human Genetics, 2010
Chromosomal microarray (CMA) is increasingly utilized for genetic testing of individuals with unexplained developmental delay/intellectual disability (DD/ID), autism spectrum disorders (ASD), or multiple congenital anomalies (MCA).
David T. Miller, Margaret P. Adam, Margaret P. Adam, S. Aradhya, L. Biesecker, A. Brothman, N. Carter, D. Church, J. Crolla, E. Eichler, C. Epstein, W. Faucett, L. Feuk, J. Friedman, A. Hamosh, L. Jackson, E. B. Kaminsky, K. Kok, I. Krantz, R. Kuhn, Charles Lee, J. Ostell, C. Rosenberg, S. Scherer, N. Spinner, D. Stavropoulos, J. Tepperberg, E. Thorland, J. Vermeesch, D. Waggoner, M. Watson, C. Martin, D. Ledbetter   +32 more
semanticscholar   +1 more source

Analysing Microarray Data using the Multi-functional Immune Ontologiser

Journal of Integrative Bioinformatics, 2006
Gene expression microarrays are a prominent experimental tool in functional genomics allowing researchers to gain a deeper understanding of biological processes.
Khalid Sabah, Khan Mohsin, Wang Ping, Liu Xiaohui, Li Suling   +4 more
doaj   +1 more source

Crosstalk between Receptor and Non-receptor Mediated Chemical Modes of Action in Rat Livers Converges through a Dysregulated Gene Expression Network at Tumor Suppressor Tp53

Frontiers in Genetics, 2017
Chemicals, toxicants, and environmental stressors mediate their biologic effect through specific modes of action (MOAs). These encompass key molecular events that lead to changes in the expression of genes within regulatory pathways.
Karen M. Funderburk, Karen M. Funderburk, Scott S. Auerbach, Pierre R. Bushel   +3 more
doaj   +1 more source

Ensifer meliloti L6-AK89, an Effective Inoculant of Medicago lupulina Varieties: Phenotypic and Deep-Genome Screening

Agronomy, 2022
This paper presents a deep analysis of the accessory genome of an economically promising strain of Ensifer (Sinorhizobium) meliloti, L6-AK89, obtained as a result of next-generation high-throughput sequencing (MiSeq, MinIon).
Marina L. Roumiantseva, Maria E. Vladimirova, Alla S. Saksaganskaia, Victoria S. Muntyan, Alexandra P. Kozlova, Alexey M. Afonin, Olga A. Baturina, Boris V. Simarov   +7 more
doaj   +1 more source

Coupled Two-Way Clustering Analysis of Gene Microarray Data [PDF]

, 2000
We present a novel coupled two-way clustering approach to gene microarray data analysis. The main idea is to identify subsets of the genes and samples, such that when one of these is used to cluster the other, stable and significant partitions emerge ...
Alizadeh, Alon, Blatt, Blatt, E. Domany, E. Levine, Eisen, G. Getz, Golub, Lander, Perou, Schena, Zhang   +12 more
core   +4 more sources

Cytology Microarrays

Analytical Cellular Pathology, 2007
The use of high throughput genetic and expression platforms are generating many candidate diagnostic markers and therapeutic targets for a wide variety of clinical conditions. Tissue microarrays can be used for the evaluation of the utility of many of these markers.
J. Korbelik, M. Cardeno, J. P. Matisic, A. C. Carraro, C. MacAulay   +4 more
openaire   +3 more sources

Small EVs-Associated DNA as Complementary Biomarker to Circulating Tumor DNA in Plasma of Metastatic Colorectal Cancer Patients

Pharmaceuticals, 2021
It is widely accepted that assessing circular tumor DNA (ctDNA) in the plasma of cancer patients is a promising practice to evaluate somatic mutations from solid tumors noninvasively.
Silvia Galbiati, Francesco Damin, Dario Brambilla, Lucia Ferraro, Nadia Soriani, Anna M. Ferretti, Valentina Burgio, Monica Ronzoni, Riccardo Vago, Laura Sola, Marcella Chiari   +10 more
doaj   +1 more source

Profound effect of profiling platform and normalization strategy on detection of differentially expressed microRNAs [PDF]

, 2012
Adequate normalization minimizes the effects of systematic technical variations and is a prerequisite for getting meaningful biological changes. However, there is inconsistency about miRNA normalization performances and recommendations.
Kaiser, Sebastian, Meyer, Swanhild U., Pfaffl, Michael W., Thirion, Christian, Wagner, Carola   +4 more
core   +1 more source

A Facile and Scalable Hydrogel Patterning Method for Microfluidic 3D Cell Culture and Spheroid-in-Gel Culture Array

Biosensors, 2021
Incorporation of extracellular matrix (ECM) and hydrogel in microfluidic 3D cell culture platforms is important to create a physiological microenvironment for cell morphogenesis and to establish 3D co-culture models by hydrogel compartmentalization. Here,
Chengxun Su, Yon Jin Chuah, Hong Boon Ong, Hui Min Tay, Rinkoo Dalan, Han Wei Hou   +5 more
doaj   +1 more source