Results 71 to 80 of about 106,998 (275)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Exploring the role of plant lysin motif receptor-like kinases in regulating plant-microbe interactions in the bioenergy crop Populus

Computational and Structural Biotechnology Journal, 2023
For plants, distinguishing between mutualistic and pathogenic microbes is a matter of survival. All microbes contain microbe-associated molecular patterns (MAMPs) that are perceived by plant pattern recognition receptors (PRRs). Lysin motif receptor-like
Kevin R. Cope, Erica T. Prates, John I. Miller, Omar N.A. Demerdash, Manesh Shah, David Kainer, Ashley Cliff, Kyle A. Sullivan, Mikaela Cashman, Matthew Lane, Anna Matthiadis, Jesse Labbé, Timothy J. Tschaplinski, Daniel A. Jacobson, Udaya C. Kalluri   +14 more
doaj   +1 more source

Nep1-like proteins from three kingdoms of life act as a microbe-associated molecular pattern in Arabidopsis [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Peptide fragments of Nep1-like proteins (NLPs), occurring in diverse microorganisms of three different kingdoms of life, were found to trigger immunity in the model plant Arabidopsis , indicating that they act as a microbe-associated molecular pattern (MAMP).
Stan Oome, Tom M. Raaymakers, Adriana Cabral, Simon Samwel, Hannah Böhm, Isabell Albert, Thorsten Nürnberger, Guido Van den Ackerveken   +7 more
openaire   +3 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Unravelling mechanisms of bacterial recognition by Acanthamoeba: insights into microbial ecology and immune responses

Frontiers in Microbiology
Acanthamoeba, are ubiquitous eukaryotic microorganisms, that play a pivotal role in recognizing and engulfing various microbes during predation, offering insights into microbial dynamics and immune responses.
Fauzy Nasher, Brendan W. Wren
doaj   +1 more source

The oomycete microbe-associated molecular pattern Pep-13 triggers SERK3/BAK1-independent plant immunity [PDF]

Plant Cell Reports, 2018
Oomycetes MAMP Pep-13 can trigger SERK3/BAK1-independent PTI. Silencing of SERK3/BAK1 in solanaceous plants resulted in reduced expression of brassinosteroid marker genes and enhanced PTI transcriptional responses to Pep-13 treatment. To prevent disease, pattern recognition receptors (PRRs) are responsible for detecting microbe-associated molecular ...
Haixia Wang, Huan He, Yetong Qi, Hazel McLellan, Zhejuan Tian, Paul R. J. Birch, Zhendong Tian   +6 more
openaire   +3 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Advances in Plant-Nematode Interactions with Emphasis on the Notorious Nematode Genus Meloidogyne. [PDF]

, 2019
Plant infections by plant-parasitic nematodes (PPNs) continue to be one of the major limitations in agricultural systems. Root-knot nematodes (RKNs), belonging to the genus Meloidogyne, are one of the most important groups of PPNs worldwide.
Kaloshian, Isgouhi, Teixeira, Marcella
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