Results 1 to 10 of about 753,950 (380)
Predicting allostery and microbial drug resistance with molecular simulations. [PDF]
Curr Opin Struct Biol, 2018 Beta-lactamase enzymes mediate the most common forms of gram-negative antibiotic resistance affecting clinical treatment. They also constitute an excellent model system for the difficult problem of understanding how allosteric mutations can augment catalytic activity of already-competent enzymes.
Cortina GA, Kasson PM.
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Chronic arsenic exposure and microbial drug resistance. [PDF]
Proc Natl Acad Sci U S A, 2013 Resistance to antimicrobial drugs represents one of the greatest threats to the control of infectious diseases and is a particular problem in treating diseases caused by parasitic protists. These pathogens are of enormous medical importance, causing diseases such as malaria, toxoplasmosis, trypanosomiasis, and leishmaniasis. In the absence of effective
McConville MJ, Ralph SA.
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Frontiers in Cellular and Infection Microbiology, 2023 Mastitis is one of the most prevalent diseases of dairy cows. Currently, mastitis treatment in dairy cows is mainly based on antibiotics. However, the use of antibiotics causes adverse effects, including drug resistance, drug residues, host-microbiome ...
Wei Guo +16 more
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Microbial spectrum and drug-resistance profile of isolates causing bloodstream infections in febrile cancer patients at a referral hospital in Addis Ababa, Ethiopia [PDF]
Infection and Drug Resistance, 2018 Balew Arega,1,2 Yimtubezinash Woldeamanuel,2 Kelemework Adane,3 Abdulaziz A Sherif,4 Daniel Asrat2 1College of Health Sciences, Debre Markos University, Debre Markos, 2Department of Microbiology, Immunology, and Parasitology, School of Medicine, College ...
Arega B +4 more
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Steps to address anti-microbial drug resistance in today’s drug discovery [PDF]
Expert Opinion on Drug Discovery, 2018 There is no doubt that antimicrobial resistance (AMR) is one of the greatest health risks to emerge in the 21st century.
Tanya Parish
semanticscholar +5 more sources
Modeling microbial drug-resistance: from mathematics to pharmacoeconomics
Фармакоэкономика, 2018 Complicated intra-abdominal infection (IAI) requires increased health care expenditures and additional resources to compensate for an ineffective starting therapy.Aim. To select the economically optimal algorithm for using antimicrobial agents (AMA) that
Yu. M. Gomon +6 more
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Fighting microbial drug resistance: a primer on the role of evolutionary biology in public health. [PDF]
Evol Appl, 2015 Although microbes have been evolving resistance to antimicrobials for millennia, the spread of resistance in pathogen populations calls for the development of new drugs and treatment strategies. We propose that successful, long‐term resistance management
Perron GG +3 more
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Transfer of Infectious Drug Resistance in Microbially Defined Mice [PDF]
Journal of Bacteriology, 1969 Germ-free mice were intentionally associated with drug-resistant donor strains of Escherichia coli known to carry R factors and with drug-sensitive recipient strains. In vivo transfer of R factors was observed in all experiments, involving five different donor-recipient combinations.
Norman D. Reed +2 more
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Microbial Colonization and Drug Resistance in Patients with Cystic Fibrosis [PDF]
Journal of Comprehensive Pediatrics, 2012 Article type: Original Article Background: Cystic fibrosis (CF) is a genetic disease with an autosomal recessive pattern of inheritance. CF caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and characterized by impaired transport of chloride ions across the cell membrane.
Soheila Khalilzadeh +5 more
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Updates on microbial resistance to drugs
African Journal of Microbiology Research, 2012 The treatment of bacterial infections and other microbial infections is increasingly complicated by the ability of bacteria and other microbes to develop resistance to antimicrobial agents. Microbial resistance to antimicrobial agents or chemotherapeutic agents had been attributed to their ability to bypass or overcome the various mechanisms by which ...
Temidayo Oluyomi Elufisan
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