Results 1 to 10 of about 346,542 (364)
Predicting allostery and microbial drug resistance with molecular simulations. [PDF]
Curr Opin Struct Biol, 2018 Beta-lactamase enzymes mediate the most common forms of gram-negative antibiotic resistance affecting clinical treatment. They also constitute an excellent model system for the difficult problem of understanding how allosteric mutations can augment catalytic activity of already-competent enzymes.
Cortina GA, Kasson PM.
europepmc +6 more sources
Modeling microbial drug-resistance: from mathematics to pharmacoeconomics
Фармакоэкономика, 2018 Complicated intra-abdominal infection (IAI) requires increased health care expenditures and additional resources to compensate for an ineffective starting therapy.Aim. To select the economically optimal algorithm for using antimicrobial agents (AMA) that
Yu. M. Gomon +6 more
doaj +5 more sources
Multimodal Role of Amino Acids in Microbial Control and Drug Development [PDF]
Antibiotics, 2020 Amino acids are ubiquitous vital biomolecules found in all kinds of living organisms including those in the microbial world. They are utilised as nutrients and control many biological functions in microorganisms such as cell division, cell wall formation,
Muhammad Idrees +3 more
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Advancing Antimicrobial Resistance Research Through Quantitative Modeling and Synthetic Biology [PDF]
Frontiers in Bioengineering and Biotechnology, 2020 Antimicrobial resistance (AMR) is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050.
Kevin S. Farquhar +2 more
doaj +2 more sources
Chronic arsenic exposure and microbial drug resistance. [PDF]
Proc Natl Acad Sci U S A, 2013 Resistance to antimicrobial drugs represents one of the greatest threats to the control of infectious diseases and is a particular problem in treating diseases caused by parasitic protists. These pathogens are of enormous medical importance, causing diseases such as malaria, toxoplasmosis, trypanosomiasis, and leishmaniasis. In the absence of effective
McConville MJ, Ralph SA.
europepmc +5 more sources
Transfer of Infectious Drug Resistance in Microbially Defined Mice [PDF]
Journal of Bacteriology, 1969 Germ-free mice were intentionally associated with drug-resistant donor strains of Escherichia coli known to carry R factors and with drug-sensitive recipient strains. In vivo transfer of R factors was observed in all experiments, involving five different donor-recipient combinations.
Norman D. Reed +2 more
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Microbial Colonization and Drug Resistance in Patients with Cystic Fibrosis [PDF]
Journal of Comprehensive Pediatrics, 2012 Article type: Original Article Background: Cystic fibrosis (CF) is a genetic disease with an autosomal recessive pattern of inheritance. CF caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and characterized by impaired transport of chloride ions across the cell membrane.
Soheila Khalilzadeh +5 more
+7 more sources
Microbial Persistence and the Road to Drug Resistance [PDF]
Cell Host & Microbe, 2013 Microbial drug persistence is a widespread phenomenon in which a subpopulation of microorganisms is able to survive antimicrobial treatment without acquiring resistance-conferring genetic changes. Microbial persisters can cause recurrent or intractable infections, and, like resistant mutants, they carry an increasing clinical burden.
Nadia Cohen +2 more
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Steps to address anti-microbial drug resistance in today’s drug discovery [PDF]
Expert Opinion on Drug Discovery, 2018 There is no doubt that antimicrobial resistance (AMR) is one of the greatest health risks to emerge in the 21st century.
Tanya Parish
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Enhanced diagnosis of multi-drug-resistant microbes using group association modeling and machine learning [PDF]
Nature CommunicationsNew solutions are needed to detect genotype-phenotype associations involved in microbial drug resistance. Herein, we describe a Group Association Model (GAM) that accurately identifies genetic variants linked to drug resistance and mitigates false ...
Julian G. Saliba +10 more
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