Results 1 to 10 of about 50 (49)
Microbial Persistence and the Road to Drug Resistance [PDF]
Cell Host & Microbe, 2013 Microbial drug persistence is a widespread phenomenon in which a subpopulation of microorganisms is able to survive antimicrobial treatment without acquiring resistance-conferring genetic changes. Microbial persisters can cause recurrent or intractable infections, and, like resistant mutants, they carry an increasing clinical burden.
Michael A. Lobritz +2 more
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Chronic arsenic exposure and microbial drug resistance [PDF]
Proceedings of the National Academy of Sciences, 2013 Resistance to antimicrobial drugs represents one of the greatest threats to the control of infectious diseases and is a particular problem in treating diseases caused by parasitic protists. These pathogens are of enormous medical importance, causing diseases such as malaria, toxoplasmosis, trypanosomiasis, and leishmaniasis. In the absence of effective
Malcolm J. McConville, Stuart A. Ralph
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Updates on microbial resistance to drugs
African Journal of Microbiology Research, 2012 The treatment of bacterial infections and other microbial infections is increasingly complicated by the ability of bacteria and other microbes to develop resistance to antimicrobial agents. Microbial resistance to antimicrobial agents or chemotherapeutic agents had been attributed to their ability to bypass or overcome the various mechanisms by which ...
B Oyelade +2 more
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Transfer of Infectious Drug Resistance in Microbially Defined Mice [PDF]
Journal of Bacteriology, 1969 Germ-free mice were intentionally associated with drug-resistant donor strains of Escherichia coli known to carry R factors and with drug-sensitive recipient strains. In vivo transfer of R factors was observed in all experiments, involving five different donor-recipient combinations.
Carl E. Georgi +2 more
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Microbial Colonization and Drug Resistance in Patients with Cystic Fibrosis [PDF]
Journal of Comprehensive Pediatrics, 2012 Article type: Original Article Background: Cystic fibrosis (CF) is a genetic disease with an autosomal recessive pattern of inheritance. CF caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and characterized by impaired transport of chloride ions across the cell membrane.
Elaheh Heydarian Fard +5 more
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Altered Microbial Composition of Drug-Sensitive and Drug-Resistant TB Patients Compared with Healthy Volunteers [PDF]
Microorganisms, 2021 Mycobacterium tuberculosis infection has three discernible outcomes: active tuberculosis, latent tuberculosis, or clearance of the bacterium. The outcome of the infection depends on the interaction of the bacterium, the immune system, and the microbiome of the host.
Fernanda Valdez-Palomares +4 more
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Predicting allostery and microbial drug resistance with molecular simulations
Current Opinion in Structural Biology, 2018 Beta-lactamase enzymes mediate the most common forms of gram-negative antibiotic resistance affecting clinical treatment. They also constitute an excellent model system for the difficult problem of understanding how allosteric mutations can augment catalytic activity of already-competent enzymes.
Peter M. Kasson +2 more
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Steps to address anti-microbial drug resistance in today’s drug discovery [PDF]
Expert Opinion on Drug Discovery, 2018 There is no doubt that antimicrobial resistance (AMR) is one of the greatest health risks to emerge in the 21st century.
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Modeling microbial drug-resistance: from mathematics to pharmacoeconomics
PHARMACOECONOMICS. Modern pharmacoeconomics and pharmacoepidemiology, 2018 Complicated intra-abdominal infection (IAI) requires increased health care expenditures and additional resources to compensate for an ineffective starting therapy.Aim. To select the economically optimal algorithm for using antimicrobial agents (AMA) that would minimize the evolving drug-resistance of microbial flora exemplified by E.
Yu. M. Gomon +6 more
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Microbial drug resistance and the roles of the new antibiotics.
Cleveland Clinic Journal of Medicine, 2001 Physicians should be cautious in prescribing broad-spectrum antibiotics, particularly vancomycin and the fluoroquinolones, because widespread use of these drugs is promoting antibiotic resistance. Resistance is now found in many organisms, including staphylococci, enterococci, streptococci, pneumococci, and Pseudomonas aeruginosa.
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