Predicting allostery and microbial drug resistance with molecular simulations. [PDF]
Curr Opin Struct Biol, 2018 Beta-lactamase enzymes mediate the most common forms of gram-negative antibiotic resistance affecting clinical treatment. They also constitute an excellent model system for the difficult problem of understanding how allosteric mutations can augment catalytic activity of already-competent enzymes.
Cortina GA, Kasson PM.
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Chronic arsenic exposure and microbial drug resistance. [PDF]
Proc Natl Acad Sci U S A, 2013 Resistance to antimicrobial drugs represents one of the greatest threats to the control of infectious diseases and is a particular problem in treating diseases caused by parasitic protists. These pathogens are of enormous medical importance, causing diseases such as malaria, toxoplasmosis, trypanosomiasis, and leishmaniasis. In the absence of effective
McConville MJ, Ralph SA.
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Fighting microbial drug resistance: a primer on the role of evolutionary biology in public health. [PDF]
Evol Appl, 2015 Although microbes have been evolving resistance to antimicrobials for millennia, the spread of resistance in pathogen populations calls for the development of new drugs and treatment strategies. We propose that successful, long‐term resistance management
Perron GG +3 more
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Steps to address anti-microbial drug resistance in today’s drug discovery [PDF]
Expert Opinion on Drug Discovery, 2018 There is no doubt that antimicrobial resistance (AMR) is one of the greatest health risks to emerge in the 21st century.
Tanya Parish
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Modeling microbial drug-resistance: from mathematics to pharmacoeconomics
PHARMACOECONOMICS. Modern pharmacoeconomics and pharmacoepidemiology, 2018 Complicated intra-abdominal infection (IAI) requires increased health care expenditures and additional resources to compensate for an ineffective starting therapy.Aim. To select the economically optimal algorithm for using antimicrobial agents (AMA) that would minimize the evolving drug-resistance of microbial flora exemplified by E.
Yu. М. Gomon +6 more
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Hygiene: microbial strategies to reduce pathogens and drug resistance in clinical settings
Microbial Biotechnology, 2017 SummaryHealthcare‐associated infections (HAIs) are a global concern, affecting all western hospitals, and profoundly impairing the clinical outcome of up to 15% of all hospitalized patients. Persistent microbial contamination of hospital surfaces has been suggested to contribute to HAIs onset, representing a reservoir for hospital pathogens.
Elisabetta Caselli
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Approaches for Mitigating Microbial Biofilm-Related Drug Resistance: A Focus on Micro- and Nanotechnologies [PDF]
Molecules, 2021 Biofilms play an essential role in chronic and healthcare-associated infections and are more resistant to antimicrobials compared to their planktonic counterparts due to their (1) physiological state, (2) cell density, (3) quorum sensing abilities, (4 ...
Harinash Rao +6 more
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Microbial Persistence and the Road to Drug Resistance [PDF]
Cell Host & Microbe, 2013 Microbial drug persistence is a widespread phenomenon in which a subpopulation of microorganisms is able to survive antimicrobial treatment without acquiring resistance-conferring genetic changes. Microbial persisters can cause recurrent or intractable infections, and, like resistant mutants, they carry an increasing clinical burden.
Michael A. Lobritz +2 more
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Transfer of Infectious Drug Resistance in Microbially Defined Mice [PDF]
Journal of Bacteriology, 1969 Germ-free mice were intentionally associated with drug-resistant donor strains of Escherichia coli known to carry R factors and with drug-sensitive recipient strains. In vivo transfer of R factors was observed in all experiments, involving five different donor-recipient combinations.
Norman D. Reed +2 more
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Microbial spectrum and drug-resistance profile of isolates causing bloodstream infections in febrile cancer patients at a referral hospital in Addis Ababa, Ethiopia [PDF]
Infection and Drug Resistance, 2018 Background The spectrum of pathogens causing bloodstream infections (BSIs) in cancer patients has shown significant fluctuations in different geographical areas and time.
Balew Arega +4 more
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