Results 61 to 70 of about 354,203 (268)

Diversity of Bacteria Exhibiting Bile Acid-inducible 7α-dehydroxylation Genes in the Human Gut

Computational and Structural Biotechnology Journal, 2019
The secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA), formed by gut microbiota from primary bile acids via a multi-step 7α-dehydroxylation reaction, have wide-ranging effects on host metabolism and play an important role in health ...
Marius Vital, Tatjana Rud, Silke Rath, Dietmar H. Pieper, Dirk Schlüter   +4 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Kueselia aquadivae gen. nov., sp. nov., the first member of the family Isosphaeraceae isolated from subsurface percolates

Scientific Reports
Subsurface habitats, found under various geological conditions, exhibit diverse microbial communities. The vadose zone, a previously unexplored subsurface compartment, connects the surface to phreatic groundwater.
Madeleine Kündgen, Tom Haufschild, Jonathan Hammer, Katharina Lehmann, Madeleine Mutter, Mareike Jogler, He Wang, Robert Lehmann, Nicolai Kallscheuer, Kai Uwe Totsche, Christian Jogler   +10 more
doaj   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

Tundrisphaera macrotermitis sp. nov., a novel member of the family Isosphaeraceae isolated from the gut of a fungus-growing termite

Scientific Reports
A pink-pigmented, neutrophilic and mesophilic strain, TA3T, was isolated from the hindgut of a fungus-growing termite of the species Macrotermes natalensis.
Nicolai Kallscheuer, Kim-Loreen Carlstedt, Jonathan Hammer, Tom Haufschild, René Benndorf, Z. Wilhelm de Beer, Michael Poulsen, Christine Beemelmanns, Christian Jogler   +8 more
doaj   +1 more source

Colonic Butyrate-Producing Communities in Humans: an Overview Using Omics Data

mSystems, 2017
Given the key role of butyrate for host health, understanding the ecology of intestinal butyrate-producing communities is a top priority for gut microbiota research.
Marius Vital, André Karch, Dietmar H. Pieper   +2 more
doaj   +1 more source

Fully Additive Vertical Organic Electrochemical Transistors on Renewable and Compostable Substrates Enable Ultrasensitive Bioelectronics

Advanced Functional Materials, EarlyView.
Fully additive vertical organic electrochemical transistors (vOECTs) with channel‐length of 226 nm on a 50 µm compostable substrate achieve >106 current modulation and ∼36 mS transconductance. Ion‐selective integration enables 1.1 mA dec−1 sensitivity and 36 µm detection limit, highlighting a scalable platform for sustainable electronics and ...
Giulia Frusconi, Samuele Lavelli, Zsolt M. Kovács‐Vajna, Fabrizio Torricelli   +3 more
wiley   +1 more source

Advances in Sustainable and Wearable Textile Based Soft Robotics

Advanced Functional Materials, EarlyView.
This Review examines advances in wearable textile‐based soft robotics, focusing on sustainable materials, integrated sensing, and scalable actuation. It discusses manufacturing and system integration across healthcare, assistive robotics, prosthetics, and human–machine interfaces, and highlights key challenges in circular design, including life‐cycle ...
Zahir Abbas, Marzia Dulal, Sophia K. Novoselov, Victoria K. Novoselov, Kostya S. Novoselov, Shaila Afroj, Nazmul Karim   +6 more
wiley   +1 more source

Segregostat: a novel concept to control phenotypic diversification dynamics on the example of Gram‐negative bacteria

Microbial Biotechnology, 2019
Summary Controlling and managing the degree of phenotypic diversification of microbial populations is a challenging task. This task not only requires detailed knowledge regarding diversification mechanisms but also advanced technical set‐ups for the real‐
Hosni Sassi, Thai Minh Nguyen, Samuel Telek, Guillermo Gosset, Alexander Grünberger, Frank Delvigne   +5 more
doaj   +1 more source

Exploring Virulence Determinants of Filamentous Fungal Pathogens through Interactions with Soil Amoebae

Frontiers in Cellular and Infection Microbiology, 2017
Infections with filamentous fungi are common to all animals, but attention is rising especially due to the increasing incidence and high mortality rates observed in immunocompromised human individuals. Here, Aspergillus fumigatus and other members of its
Silvia Novohradská, Silvia Novohradská, Iuliia Ferling, Iuliia Ferling, Falk Hillmann   +4 more
doaj   +1 more source