Results 151 to 160 of about 10,401 (257)

Iso‐ and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On‐Target Activity Through Scaffold Decoration and In Situ Warhead Generation

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
We explore covalent allosteric targeting of MGL regulatory cysteines using iso‐ and benzisothiazolinone scaffolds. Combining mechanism‐based warhead release with structure‐guided scaffold decoration to improve molecular recognition, this study probes strategies to achieve selective on‐target engagement beyond the catalytic site. Monoacylglycerol lipase
Edoardo Rocca, Annalida Bedini, Laura Scalvini, Francesca Galvani, Riccardo Castelli, Lorenzo Sarcone, Adriano Recchia, Fabiola Fanini, Adren Tran, Silvia Rivara, Gilberto Spadoni, Daniele Piomelli, Marco Mor   +12 more
wiley   +1 more source

Microbial and enzymatic synergy in fermented fish: impacts on flavor, texture, and safety with multi-omics and AI insights. [PDF]

Food Chem X
Dai L, Chen L, Xiao Y, Zheng S, Hou G, Zheng B, Zhang L.   +6 more
europepmc   +1 more source

Biodegradation of polyethylene terephthalate microplastics by Paenibacillus naphthalenovorans PETKKU2: Response surface optimization and genomic evidence for an alternative degradation mechanism. [PDF]

PLoS One
Choonut A, Wongfaed N, Poolpol A, Boonlue S, Wantala K, Pinyakong O, Plangklang P, Reungsang A.   +7 more
europepmc   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, Volume 13, Issue 46, 17 August 2026.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Isolation and Functional Profiling of Seed-Associated Bacteria From Rattlepods (<i>Crotalaria</i> spp.) With Biotechnological Potential. [PDF]

Int J Microbiol
Odoi BA, Nthiwa DM, Neondo JO, Muli JK, Kamau PK, Budambula NLM.   +5 more
europepmc   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, Volume 13, Issue 47, 24 August 2026.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Metabolic Responses of <i>Candida viswanathii</i> on Lipase Production: Influence of Carbon Sources and Culture System. [PDF]

ACS Omega
de Oliveira NML, Paula-Elias FC, Contiero J, Pinto RR, Xavier MCA, Carvalho NB, Leite PC, Perna RF, Morales SAV, Almeida AF.   +9 more
europepmc   +1 more source

Comparative Efficiency of Two Indigenously Isolated Probiotic Strains on Growth Performance and Health Profile of Advance Fry of Labeo rohita

Aquaculture, Fish and Fisheries, Volume 6, Issue 4, August 2026.
ABSTRACT Due to variations in the mode of action and efficacy, the “one‐size‐fits‐all” model cannot be applied to probiotics. Thus, selecting specific probiotic strains/species for the selected fish species in a particular culture condition/environment is a prerequisite to acquire maximal benefits.
Imrana Amir, Amina Zuberi, Abeer Kazmi, Muhammad Kamran, Muhammad Imran, Aamir Amanat Ali Khan, Md. Fakhrul Islam, Aneela Nijabat, Gabriela Medina‐Pérez, Armando Pelaez‐Acero, Amir Ali   +10 more
wiley   +1 more source

Microbial Ecology at the Nexus of Food Safety and Biotechnology With Ecological Mechanisms, Risks, and Emerging Innovations. [PDF]

Int J Food Sci
Tepson JA, Agyirifo DS.
europepmc   +1 more source

Abalone Gut Microbiome Regulators: A Review Synthesizing Gut Physiology, Microorganisms, Diet and the Environment

Aquaculture, Fish and Fisheries, Volume 6, Issue 4, August 2026.
ABSTRACT Abalone are economically, ecologically and culturally significant marine molluscs, with both wild and farmed populations under pressure due to intrinsic and extrinsic stressors. Abalone performance and health are centred on a highly specialized digestive system supported by a diverse gut microbiome, which enables nutrient assimilation ...
Jinchen Guo, Leonie Venter, Donnabella C. Lacap‐Bugler, Andrea C. Alfaro   +3 more
wiley   +1 more source