Results 131 to 140 of about 112,228 (309)

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

A Novel Rhodotorula evergladensis CXCN-6 Rich in Torularhodin and PUFAs with Potent Antioxidant and Anti-Inflammatory Activities

Antioxidants
Carotenoids and microbial lipids are valuable bioactive compounds with potent antioxidant and anti-inflammatory properties. Microbial biosynthesis provides a sustainable alternative to conventional plant extraction and chemical synthesis. Here, we report
Chaiwoo Park, Myeongsam Park, Tingting Li, Chunxiao Shen, Zuxuan Zheng, Yitong Ge, Xuanyan Jin, Maolin Wei, Jaehwan Choi, Jae Sung Hwang, Zhengqun Li   +10 more
doaj   +1 more source

Microbial Lipids

Oleoscience, 2023
openaire   +1 more source

Resistant Peanut Genotype Reprograms Rhizosphere Metabolism to Enhance Bacterial Wilt Suppression

Advanced Science, EarlyView.
The resistant peanut genotype selectively recruits beneficial bacteria, which coincides with the activation of salicylic acid (SA)‐dependent systemic acquired resistance (SAR) against Ralstonia solanacearum. Keystone rhizosphere metabolites are positively correlated with both beneficial microbiome assembly and SAR gene expression.
Rui Ren, Xiaogang Li, Hao Li, Zenghui Cao, Mengtian Hou, Chunlei Zhao, Nan Lou, Sasa Hu, Yanzhe Li, Qian Ma, Yaoyao Li, Yi Fan, Kunkun Zhao, Kai Zhao, Ding Qiu, Fangping Gong, Zhongfeng Li, Haitao Liu, Xingli Ma, Xingxiang Wang, Dongmei Yin   +20 more
wiley   +1 more source

An Edible Biohybrid Platform Accomplishes In Situ Fenton‐Mediated Enteral Nanoplastics Aging and Excretion

Advanced Science, EarlyView.
An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou, Anran Yan, Haowei Guo, Ping Chen, Qiang Chu   +4 more
wiley   +1 more source

In Vitro Evaluation of the Antimicrobial, Antioxidant, and Cytotoxicity Potential Coupled with Molecular Docking Simulation of the Dynamic Fermentation Characteristics of Marine-Derived Bacterium Halomonas saccharevitans

Fermentation
A variety of metabolites produced by marine microorganisms are gaining high value for their significant biological properties. Therefore, the search for active secondary metabolites from marine bacteria against pathogenic microorganisms has become ...
Hassan Mohamed, Mohamed A. A. Abdrabo, Sahar W. M. Hassan, Hassan A. H. Ibrahim, Mohmed F. Awad, Usama M. Abdul-Raouf, Yuanda Song   +6 more
doaj   +1 more source

Bioconversion of volatile fatty acids into microbial lipids by Yarrowia lipolytica [PDF]

, 2018
Volatile fatty acids (VFAs) are short chain fatty acids that can be obtained from organic wastes through acidogenic fermentation and can be used as carbon source for microbial lipids production.
Belo, Isabel, Miranda, Sílvia M., Pereira, Ana Sofia, Lopes, Marlene   +3 more
core  

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

²H/¹H variation in microbial lipids is controlled by NADPH metabolism. [PDF]

Proc Natl Acad Sci U S A, 2019
Wijker RS, Sessions AL, Fuhrer T, Phan M.   +3 more
europepmc   +1 more source