Results 161 to 170 of about 1,092,902 (309)

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

Advanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin, Sisi Chen, Shengli Huang, Mengqi Huang, Jingyan Zhu, Zijian Wang, Jianliang Shen, Qinxiang Zheng   +7 more
wiley   +1 more source

Porcupine‐Quill‐Inspired Shape‐Morphing Biointerfaces Disassemble Biofilms

Advanced Science, EarlyView.
A porcupine‐spine‐inspired dynamic offensive bio‐interface is developed for active biofilm disassembly. By coupling electrically driven nano‐dagger penetration with light‐triggered ROS generation, the surface overcomes the passive limitations of conventional mechano‐bactericidal topographies, achieving near‐complete biofilm eradication, strong ...
Feng Qian, Muqiu Xia, Ziyu Wang, Xinyuan Jia, Jinke Yin, Mengyu Fu, Xue Zhang, Xiao‐Lei Shi, Shiqiang Chen, Ning Wang, Zhi‐Gang Chen   +10 more
wiley   +1 more source

Intratumoral Fusogenic Outer Membrane Vesicles Enhance Antitumor Immunity Through Tumor MHC‐I Upregulation and Tumor Bacterization

Advanced Science, EarlyView.
Tumor bacterization by fusogenic outer membrane vesicles enhances microbial‐like recognition of tumor cells while activating the TLR4–NF‐κB–NLRC5 axis to upregulate MHC class I expression. By simultaneously strengthening APC sensing and T‐cell recognition, this strategy breaks tumor immune invisibility and promotes more effective antitumor immune ...
Xing Liu, Jiaxin Zhou, Guihong Lu, Chenjing Zhao, Weixiu Wang, Jichuan Chen, Fengqi Zhang, Fan Zhang, Hai‐Yan Xie, Weidong Nie   +9 more
wiley   +1 more source

Loss of Intestinal MSTN Promotes GLP‐1 Secretion Through SGLT1 Palmitoylation

Advanced Science, EarlyView.
Intestinal MSTN deficiency enhances glucose‐stimulated GLP‐1 secretion and glucose tolerance in high‐fat diet‐fed mice. Mechanistically, loss of MSTN promotes YY1‐associated ZDHHC20 expression, increasing SGLT1 S‐palmitoylation at Cys301 and its plasma membrane localization in L cells.
Sheng‐Zhong Han, Shuang‐Yan Chang, Zhaobo Luo, Ke Sun, Biaohu Quan, Yanqiu Lv, Zhouyan Li, Xinyue Liu, Sitong Lv, Meifu Xuan, Xiaoyufan Xu, Xue Fang, Hang Chang, Rihuan Zhang, Xi‐Jun Yin, Lin‐Hu Quan, Jin‐Dan Kang   +16 more
wiley   +1 more source

Multi‐Omics Analyses Identify Candidate Genes Associated With Stage‐Specific Quality Formation in Mulching‐Treated Moso Bamboo Shoots

Advanced Science, EarlyView.
Organic mulching reprograms Moso bamboo shoot development, enhancing yield and nutritional quality. This multi‐omics study reveals that coordinated metabolic, transcriptional, and post‐transcriptional regulation drives stage‐specific quality formation, offering comprehensive insights into how this agricultural practice improves crop performance and ...
Bo Wang, Yanbin Wang, Chunyue Wang, Zishan Ahmad, Peixin Teng, Huijing Ni, Qiang Wei, Muthusamy Ramakrishnan   +7 more
wiley   +1 more source

Sacral Neural Crest‐Derived Extracellular Vesicles Promote Pelvic Ganglion Repair Through Anti‐Pyroptotic Effects Involving ANXA1–FPR2 Signaling

Advanced Science, EarlyView.
Extracellular vesicles derived from human pluripotent stem cell‐derived sacral neural crest cells promote repair of injured major pelvic ganglia and improve colorectal function. These vesicles reduce oxidative stress and pyroptosis, with ANXA1–FPR2 signaling contributing to their protective effects, and show a favorable therapeutic profile compared ...
Ting Yang, Wenwei Liu, Hufei Wang, Yuxin Wu, Yuanchen Ma, Xiaofeng Wang, Tianxiang Lei, Qiao Tang, Yebohao Zhou, Weiqiang Li, Andy Peng Xiang, Wu Song   +11 more
wiley   +1 more source

Chrysanthemum Morifolium–Derived Nanovesicles Reduce Lactate‐Associated Histone Lactylation and Modulate Microglia‐Mediated Neuroinflammation in Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
When used to treat sepsis‐associated encephalopathy, Chrysanthemum morifolium–derived nanovesicles can inhibit the H3K18la/NF‐κB axis to regulate microglia‐mediated neuroinflammation. ABSTRACT Sepsis‐associated encephalopathy (SAE)—a complication of the central nervous system in patients with sepsis—markedly diminishes cognitive functions and is linked
Kaiqiang Li, Xuling Luo, Xiaoting Zhang, Chengwen He, Wei Xu, Aibo Xu, Shushan Hua, Liping Wang, Liang Ma, Ke Hao, Youmin Ying, Zhen Wang   +11 more
wiley   +1 more source

Engineered Chiral Probiotics Ameliorate MASH via Gut–Liver Axis

Advanced Science, EarlyView.
A chiral gold nanozyme was coated onto the gut commensal bacterium Faecalibacterium duncaniae (F. duncaniae) to create an engineered probiotic. In mouse models of MASH, this orally administered living therapeutic protected the bacterium against oxidative stress, enhanced its gut colonization, reversed steatosis, inflammation, and fibrosis, and improved
Jing Chen, Shen Zhang, Yuli Zhu, Da Zhou, Chunya Ji, Mingrui Zhu, Sirui Wang, Yuting Shen, Jifeng Yu, Heng Zhang, Yan Fang, Huixiong Xu, Haohao Yin   +12 more
wiley   +1 more source

Interface‐Confined Cavitation at an MXene/TiO2 Schottky Heterointerface for Non‐Thermal Juice Preservation

Advanced Science, EarlyView.
This work establishes an MXene/TiO2 Schottky heterointerface for non‐thermal sonocatalysis. Interface‐confined cavitation and dynamic Ti3+/V₀ shuttles drive charge transport and reactive oxygen species (ROS) generation. The platform achieves 3‐log pathogen reduction while retaining heat‐labile nutrients in complex food matrices, redefining sonocatalyst
Xiaoge Wu, Yunxiao Zhu, Nan Qin, Zhaoli Zhang, Qi Zhang, Yang Tao   +5 more
wiley   +1 more source

Nanocatalytic Immunotherapy Targeting Tumor‐Resident Intracellular Bacteria for Triple‐Negative Breast Cancer Treatment and Metastasis Suppression

Advanced Science, EarlyView.
Bacteria residing within tumor cells contribute to breast cancer progression, but few therapies target their elimination. FeSe2 nanosheets coated with cancer cell membranes accumulate in tumors and generate reactive oxygen species under ultrasound, killing tumor cells and their harbored bacteria at the same time.
Xiaojing Leng, Tao Jiang, Zhao Guo, Zhimin Zhang, Yihan Chen, Pan Li, Min Ge, Han Lin, Liang Zhang   +8 more
wiley   +1 more source