Results 41 to 50 of about 174,422 (248)

S9.6-based hybrid capture immunoassay for pathogen detection

Scientific Reports, 2023
The detection of pathogens is critical for clinical diagnosis and public health surveillance. Detection is usually done with nucleic acid-based tests (NATs) and rapid antigen tests (e.g., lateral flow assays [LFAs]).
Ankur Bothra, Megan L. Perry, Elena Wei, Mahtab Moayeri, Qian Ma, Marco A. Biamonte, Marina Siirin, Stephen H. Leppla   +7 more
doaj   +1 more source

Multiple Signals Govern Utilization of a Polysaccharide in the Gut Bacterium Bacteroides thetaiotaomicron

mBio, 2016
The utilization of simple sugars is widespread across all domains of life. In contrast, the breakdown of complex carbohydrates is restricted to a subset of organisms.
Nathan D. Schwalm, Guy E. Townsend, Eduardo A. Groisman   +2 more
doaj   +1 more source

Pathogenesis of Microbial Disease

International Journal of Orofacial Biology, 2023
Pathogenesis refers to the process through which a disease or illness develops. The majority of infections are caused by a number of microbial species. The average human body contains 10 trillion human cells that include approximately 100 trillion bacteria and other microorganisms. Humans and their naturally occurring microflora have a tangled mutually
openaire   +1 more source

Microbial Pathogenesis: Mechanisms of Infectious Disease [PDF]

Cell Host & Microbe, 2007
The FASEB Summer Research Conference on Microbial Pathogenesis: Mechanisms of Infectious Disease was held in Colorado, USA in July 2007. The central theme was the interplay between pathogenic microbes and their mammalian hosts. Here, we review the presented research that highlights this theme, including studies of both short-term and long-term ...
Carruthers, Vern B., Cotter, Peggy A., Kumamoto, Carol A.   +2 more
openaire   +4 more sources

HIV-1 transcription dominates over host gene activity at the HIV-1 integration site

mBio
Despite effective antiretroviral therapy (ART), HIV-1 persists as an integrated DNA provirus in the genome of infected cells. Host cells can regulate HIV-1 transcription at the HIV-1 integration site dependent on the location (actively transcribed genes ...
Samuel Weissman, Yang-Hui J. Yeh, Miriam Viazmenski, Rachel Kim, Jack A. Collora, Savannah Steinhauser, Ya-Chi Ho   +6 more
doaj   +1 more source

Antibodies against the Majority Subunit (PilA) of the Type IV Pilus of Nontypeable Haemophilus influenzae Disperse Moraxella catarrhalis from a Dual-Species Biofilm

mBio, 2018
Otitis media (OM) is often polymicrobial, with nontypeable Haemophilus influenzae (NTHI) and Moraxella catarrhalis (Mcat) frequently cocultured from clinical specimens.
Elaine M. Mokrzan, Laura A. Novotny, Kenneth L. Brockman, Lauren O. Bakaletz   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Microbial Pathogenesis: New Niches for Salmonella [PDF]

Current Biology, 2002
Salmonella occupies a vacuolar compartment inside cells of its host. Recent studies have shown that the fate of this vacuole is different in various cell types, and that the outcome of colonization is determined by both the infecting bacterium and defense mechanisms of the host cell.
Brumell, J.H, Perrin, A.J, Goosney, D.L, Finlay, B.B   +3 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Stem Cell-Derived Viral Antigen-Specific T Cells Suppress HIV Replication and PD-1 Expression on CD4+ T Cells

Viruses, 2021
The viral antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) derived from pluripotent stem cells (PSCs), i.e., PSC-CTLs, have the ability to suppress the human immunodeficiency virus (HIV) infection.
Mohammad Haque, Fengyang Lei, Xiaofang Xiong, Yijie Ren, Hao-Yun Peng, Liqing Wang, Anil Kumar, Jugal Kishore Das, Jianxun Song   +8 more
doaj   +1 more source