Results 51 to 60 of about 183,249 (254)

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

The conventional pathogenic flora compositions: An overview of the trends used for bacterial pathogenicity identifications

, 2018
Over 250 species of resident flora in the class of bacteria are known to be associated with humans. These conventional flora compositions is often determined by factors which may not be limited to genetics, age, sex, stress and nutrition of humans.
Ugbogu, Eziuche Amadike, Chinyere Ugbogu, Ositadinma, Elghandour, Mona M.M.Y., Anayo Orji, Frank, Monroy, Jose Cedillo, Salem, Abdelfattah Z.M., Barbabosa-Pliego, Alberto   +6 more
core   +1 more source

Global Transcriptomics Uncovers Distinct Contributions From Splicing Regulatory Proteins to the Macrophage Innate Immune Response

Frontiers in Immunology, 2021
Pathogen sensing via pattern recognition receptors triggers massive reprogramming of macrophage gene expression. While the signaling cascades and transcription factors that activate these responses are well-known, the role of post-transcriptional RNA ...
Allison R. Wagner, Haley M. Scott, Kelsi O. West, Krystal J. Vail, Krystal J. Vail, Timothy C. Fitzsimons, Aja K. Coleman, Kaitlyn E. Carter, Robert O. Watson, Kristin L. Patrick   +9 more
doaj   +1 more source

Gut Microbial Metabolite-Mediated Regulation of the Intestinal Barrier in the Pathogenesis of Inflammatory Bowel Disease

, 2021
Inflammatory bowel disease (IBD) is a chronic inflammatory disease. The disease has a multifactorial aetiology, involving genetic, microbial as well as environmental factors.
Namrata Iyer, Iyer, Namrata, Corr, Sinéad C., Sinéad C. Corr   +3 more
core   +1 more source

Benefits and costs of immune memory in Rhodnius prolixus against Trypanosoma cruzi [PDF]

, 2022
Artículo científico de derivado de la tesis de maestría de la Maestra Sonia Patricia Carmona peña, estudiante del Programa de Maestría y Doctorado en Ciencias Agropecuarias y Recursos Naturales de la UAEMex.
Genta, Fernando, CONTRERAS GARDUÑO, JORGE ALBERTO, VAZQUEZ CHAGOYAN, JUAN CARLOS, Castro, Danielle P, Carmona Peña, Sonia Patricia   +4 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Translation of peptidoglycan metabolites into immunotherapeutics

Clinical & Translational Immunology, 2019
The discovery of defined peptidoglycan metabolites that activate host immunity and their specific receptors has revealed fundamental insights into host–microbe recognition and afforded new opportunities for therapeutic development against infection and ...
Matthew E Griffin, Charles W Hespen, Yen‐Chih Wang, Howard C Hang   +3 more
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Interplay between SpaO variants shapes the architecture of the Salmonella type III secretion sorting platform

mBio
Salmonella enterica utilizes a virulence-associated type III secretion system (T3SS) to inject bacterial effectors directly into host cells. Central to this machinery is the sorting platform (SP), a cytosolic assembly whose core scaffolding protein, SpaO,
José Eduardo Soto, Tingting Wang, Jorge E. Galán, Maria Lara-Tejero   +3 more
doaj   +1 more source