Results 71 to 80 of about 183,249 (254)

Induction of apoptosis in human neutrophils by Mycobacterium tuberculosis is dependent on mature bacterial lipoproteins

, 2009
Modulation of immune cell apoptosis is a key evasion strategy utilized by Mycobacterium tuberculosis (Mtb). To be able to multiply within macrophages, the bacterium delays apoptosis and down-regulates pro-inflammatory activation in these cells, whereas ...
Blomgran, Robert,, Lundstrom, Charlotte, Alexander Persson, Robert Blomgran-Julinder, Blomgran-Julinder, Robert,, Eklund, Daniel, Blomgran, Robert, Stendahl, Olle, Eklund, Daniel,, Stendahl, Olle,, Charlotte Lundström, Lundstrom, Charlotte,, Daniel Eklund, Olle Stendahl, Persson, Alexander, Persson, Alexander,   +15 more
core   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages

Cell Reports, 2019
Summary: While transcriptional control of innate immune gene expression is well characterized, almost nothing is known about how pre-mRNA splicing decisions influence, or are influenced by, macrophage activation.
Kelsi O. West, Haley M. Scott, Sylvia Torres-Odio, A. Phillip West, Kristin L. Patrick, Robert O. Watson   +5 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Flaviviruses manipulate mitochondrial processes to evade the innate immune response

npj Viruses
Mitochondria are essential eukaryotic organelles that regulate a range of cellular processes, from metabolism to calcium homeostasis and programmed cell death.
RuthMabel Boytz, Kadiatou Keita, Joanna B. Pawlak, Maudry Laurent-Rolle   +3 more
doaj   +1 more source

Putative outer membrane proteins of Leptospira interrogans stimulate human umbilical vein endothelial cells (HUVECS) and express during infection

, 2008
Cell adhesion molecules (CAMs) are surface receptors present in eukaryotic cells that mediate cell-cell or cell-extracellular matrix interactions. Vascular endothelium stimulation in vitro that lead to the upregulation of CAMs was reported for the ...
VIEIRA, Monica L., ABREU, Patricia A. E., CIFUENTE, Javier O., MALAVER, Elisa, ATZINGEN, Marina V., VASCONCELLOS, Silvio A., OLIVEIRA, Tatiane R., NASCIMENTO, Ana L. T. O., MORAIS, Zenaide M. de, GOMEZ, Ricardo M., SCHATTNER, Mirta, BARBOSA, Angela S., WATANABE, Monica M.   +12 more
core   +1 more source

Cotton Recruits Soil‐Derived Delftia tsuruhatensis to Suppress Aphid Detoxification Via Salicylic Acid‐Mediated Defense

Advanced Science, EarlyView.
This study systematically reveals a complex interactive network involving plants, microbes, and insects, elucidating the ecological and molecular mechanisms by which cotton enhances its resistance to aphids through the active recruitment of the beneficial soil bacterium Delftia tsuruhatensis.
Hui Xue, Fengchao Diao, Qiqing Yu, Xiangzhen Zhu, Tingfang Zhong, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Junyu Luo, Jinjie Cui, Xueke Gao   +11 more
wiley   +1 more source

Glycan-Glycan Interaction Determines Shigella Tropism toward Human T Lymphocytes

mBio, 2018
Direct interactions between bacterial and host glycans have been recently reported to be involved in the binding of pathogenic bacteria to host cells. In the case of Shigella, the Gram-negative enteroinvasive bacterium responsible for acute rectocolitis,
Ilia Belotserkovsky, Katja Brunner, Laurie Pinaud, Alexander Rouvinski, Mariano Dellarole, Bruno Baron, Gyanendra Dubey, Fatoumata Samassa, Claude Parsot, Philippe Sansonetti, Armelle Phalipon   +10 more
doaj   +1 more source

Microbial Pathogenesis

, 2013
Texto completo. Acesso restrito. p. 37–42This study involves the comparison between the exoproteomes of two different strains of Corynebacterium pseudotuberculosis, the etiologic agent of caseous lymphadenitis in small ruminants.
Azevedo, Vasco Ariston de Carvalho, Silva, Artur Luiz da Costa da, Andrade, Hélida M., Silva, Wanderson M., Ciprandi, Alessandra, Miyoshi, Anderson, Santos, Agenor V., Seyffert, Núbia, Dorella, Fernanda Alves, Barh, Debmalya, Pimenta, Adriano Monteiro de Castro, Santos, Anderson Rodrigues dos, Pacheco, Luis Gustavo Carvalho, Castro, Thiago Luiz de Paula   +13 more
core  

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source