Results 91 to 100 of about 183,249 (254)

Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription

Cell Reports
Summary: Tight regulation of macrophage immune gene expression is required to fight infection without risking harmful inflammation. The contribution of RNA-binding proteins (RBPs) to shaping the macrophage response to pathogens remains poorly understood.
Haley M. Scott, Mackenzie H. Smith, Aja K. Coleman, Kaitlyn S. Armijo, Morgan J. Chapman, Summer L. Apostalo, Allison R. Wagner, Robert O. Watson, Kristin L. Patrick   +8 more
doaj   +1 more source

Cysteine Protease-Mediated Autocleavage of Clostridium difficile Toxins Regulates Their Proinflammatory ActivitySummary

Cellular and Molecular Gastroenterology and Hepatology, 2018
Background & Aims: Clostridium difficile toxin A (TcdA) and C difficile toxin toxin B (TcdB), the major virulence factors of the bacterium, cause intestinal tissue damage and inflammation.
Yongrong Zhang, Shan Li, Zhiyong Yang, Lianfa Shi, Hua Yu, Rosangela Salerno-Goncalves, Ashley Saint Fleur, Hanping Feng   +7 more
doaj   +1 more source

Binding and activation of plasminogen at the surface of Fusobacterium necrophorum

, 2013
Fusobacterium necrophorum is a gram-negative, anaerobic bacterium, which has been suggested to be a normal inhabitant of the oral flora. In rare cases, it can invade the tonsils and deeper tissues, causing the serious condition Lemièrre's syndrome ...
Holm, Karin,, Lund University., Rasmussen, Magnus,   +2 more
core   +1 more source

The immunomodulatory effects of probiotics on respiratory viral infections: A hint for COVID-19 treatment?

, 2020
Respiratory virus infections are among the most prevalent diseases in humans and contribute to morbidity and mortality in all age groups. Moreover, since they can evolve fast and cross the species barrier, some of these viruses, such as influenza A and
Mahooti, Mehran, Mohammad Miri, Seyed, Abdolalipour, Elahe, Ghaemi, Amir   +3 more
core   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

TLR4 in Toxoplasmosis; friends or foe?

, 2014
Toxoplasma species are obligate intracellular protozoan which are responsible for induction of several forms of Toxoplasmosis in humans. The mechanisms responsible for the progression of the prolonged forms of Toxoplasmosis and associated pathologies are
Bidaki, Mohammad Zare, Kennedy, Derek, Abdollahi, Seyyed Hossein, Hakimi, Hamid, Zare-Bidaki, Mohammad, Arababadi, Mohammad Kazemi, Zainodini, Nahid   +6 more
core   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Host Antimicrobial Peptides in Bacterial Homeostasis and Pathogenesis of Disease

Antibiotics, 2014
Innate immune responses function as a first line of host defense against the development of bacterial infection, and in some cases to preserve the sterility of privileged sites in the human host.
Derek R. Heimlich, Alistair Harrison, Kevin M. Mason   +2 more
doaj   +1 more source

Pathogenesis of mixed infection by Spironucleus sp. and Citrobacter freundii in freshwater angelfish Pterophyllum scalare

, 2016
The present study was carried out to identify and describe the pathology of the freshwater angelfish Pterophyllum scalare during chronic mortality in an in-door aquaculture system.
Valladão, Gustavo M.R., Gallani, Sílvia U., Boaratti, André Z. [UNESP], Sebastião, Fernanda de A., Gallani, Sílvia U. [UNESP], Pilarski, Fabiana [UNESP], Pilarski, Fabiana, Sebastião, Fernanda de A. [UNESP], Boaratti, André Z., Valladão, Gustavo M.R. [UNESP]   +9 more
core   +1 more source

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source