Results 81 to 90 of about 183,249 (254)

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Microbial Pathogenesis: Mechanisms of Infectious Disease

, 2007
SummaryThe FASEB Summer Research Conference on Microbial Pathogenesis: Mechanisms of Infectious Disease was held in Colorado, USA in July 2007. The central theme was the interplay between pathogenic microbes and their mammalian hosts. Here, we review the
Cotter, Peggy A., Carruthers, Vern B., Kumamoto, Carol A.   +2 more
core   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Composite mobile genetic elements disseminating macrolide resistance in Streptococcus pneumoniae

Frontiers in Microbiology, 2015
Macrolide resistance in Streptococcus pneumoniae emerged in the US and globally during the early 1990’s. The RNA methylase encoded by erm(B) and the macrolide efflux genes mef(E) and mel were identified as the resistance determining factors.
Scott T Chancey, Scott T Chancey, Sonia eAgrawal, Max eSchroeder, Max eSchroeder, Monica M. Farley, Monica M. Farley, Hervé eTettelin, Hervé eTettelin, Hervé eTettelin, David S. Stephens, David S. Stephens   +11 more
doaj   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Virulence factors in isolates of Enterococcus faecalis from infective endocarditis and from the normal flora

, 2012
Infective endocarditis (IE) is a severe infection associated with significant morbidity and mortality. Enterococcus faecalis is among the most common causes of this disease, and yet little is known about the pathogenesis of E. faecalis IE. We screened 21
Johansson, Daniel,, Lund University., Rasmussen, Magnus,   +2 more
core   +1 more source

Bactericidal effect of silver nanoparticles against propagation of Clavibacter michiganensis infection in Lycopersicon esculentum Mill [PDF]

, 2018
El estudio explora el uso de nanoparticulas de plata como bactericida contra Clavibacter michiganensis en jitomate. Se encontró una concentración optima y se puede señalar a estas nanoparticluas como inhibidor de bacterias.This study explored the use of ...
STEPHANO HORNEDO, JOSE LUIS; 797773, CAMACHO DIAZ, LUIS MIGUEL, Alaba, Peter;#, Lugo, Jorge;#, Rivas Caceres, Raymundo Rene, STEPHANO HORNEDO, JOSE LUIS, VACA PAULIN, ROCIO, Alaba, Peter, Lugo, Jorge, CIPRIANO SALAZAR, MOISES, CIPRIANO SALAZAR, MOISES; 63940, VACA PAULIN, ROCIO; 201258, CAMACHO DIAZ, LUIS MIGUEL; 210700, Rivas Caceres, Raymundo Rene ; 102150   +13 more
core   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Initial Biochemical And Functional Characterization Of A 5'-nucleotidase From Xylella Fastidiosa Related To The Human Cytosolic 5'-nucleotidase I

, 2015
The 5'-nucleotidases constitute a ubiquitous family of enzymes that catalyze either the hydrolysis or the transfer of esterified phosphate at the 5' position of nucleoside monophosphates. These enzymes are responsible for the regulation of nucleotide and
Toledo M.A.S., Saraiva A.M., Santiago A.S., Crucello A., Horta M.A.C., Mendes J.S., Santos C.A., Souza A.A., Beloti L.L., Favaro M.T.P., Souza A.P.   +10 more
core   +2 more sources

Resistant Peanut Genotype Reprograms Rhizosphere Metabolism to Enhance Bacterial Wilt Suppression

Advanced Science, EarlyView.
The resistant peanut genotype selectively recruits beneficial bacteria, which coincides with the activation of salicylic acid (SA)‐dependent systemic acquired resistance (SAR) against Ralstonia solanacearum. Keystone rhizosphere metabolites are positively correlated with both beneficial microbiome assembly and SAR gene expression.
Rui Ren, Xiaogang Li, Hao Li, Zenghui Cao, Mengtian Hou, Chunlei Zhao, Nan Lou, Sasa Hu, Yanzhe Li, Qian Ma, Yaoyao Li, Yi Fan, Kunkun Zhao, Kai Zhao, Ding Qiu, Fangping Gong, Zhongfeng Li, Haitao Liu, Xingli Ma, Xingxiang Wang, Dongmei Yin   +20 more
wiley   +1 more source