Results 31 to 40 of about 174,422 (248)

Role of Sphingolipids in Microbial Pathogenesis [PDF]

Infection and Immunity, 2006
The sphingolipids are a class of lipids that serve as integral components of eukaryotic cell membranes ([21][1], [49][2]). Although previously considered to be simply structural molecules, sphingolipids have more recently been shown to act as signaling molecules in many cellular functions and ...
Lena J, Heung, Chiara, Luberto, Maurizio, Del Poeta   +2 more
openaire   +2 more sources

De Novo Isolation & Affinity Maturation of yeast-displayed Virion-binding human fibronectin domains by flow cytometric screening against Virions

Journal of Biological Engineering, 2019
Background The promise of biopharmaceuticals comprising one or more binding domains motivates the development of novel methods for de novo isolation and affinity maturation of virion-binding domains.
Pete Heinzelman, Alyssa Low, Rudo Simeon, Gus A. Wright, Zhilei Chen   +4 more
doaj   +1 more source

Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection

mBio, 2023
There is a limited understanding of host defense mechanisms targeting intracellular pathogens that proliferate in a lysosome. Coxiella burnetii is a model bacterial pathogen capable of replicating in the hydrolytic and acidic environment of the lysosome.
Sandhya Ganesan, Natalie N. Alvarez, Samuel Steiner, Karen M. Fowler, Abigail K. Corona, Craig R. Roy   +5 more
doaj   +1 more source

T Cell Response to SARS-CoV-2 Coinfection and Comorbidities

Pathogens, 2023
For the past three years, COVID-19 has become an increasing global health issue. Adaptive immune cells, especially T cells, have been extensively investigated in regard to SARS-CoV-2 infection. However, human health and T cell responses are also impacted
Liqing Wang, Hao-Yun Peng, Aspen Pham, Eber Villazana, Darby J. Ballard, Jugal Kishore Das, Anil Kumar, Xiaofang Xiong, Jianxun Song   +8 more
doaj   +1 more source

Novel Components of the Flagellar System in Epsilonproteobacteria

mBio, 2014
Motility is essential for the pathogenesis of many bacterial species. Most bacteria move using flagella, which are multiprotein filaments that rotate propelled by a cell wall-anchored motor using chemical energy. Although some components of the flagellar
Beile Gao, Maria Lara-Tejero, Matthew Lefebre, Andrew L. Goodman, Jorge E. Galán   +4 more
doaj   +1 more source

Stabilization of Tuberculosis Reporter Enzyme Fluorescence (REFtb) Diagnostic Reagents for Use at the Point of Care

Diagnostics, 2022
Tuberculosis is one of the most frequent causes of death in humans worldwide. One of the primary reasons tuberculosis remains a public health threat is that diagnosis can take weeks to months, is often not very sensitive and cannot be accomplished in ...
Maxim Lebedev, Aaron B. Benjamin, Kent J. Koster, Kathryn E. Broyles, Sathish Kumar, Joseph M. Jilka, Jeffrey D. Cirillo   +6 more
doaj   +1 more source

Synergistic Antimicrobial Effects of Ibuprofen Combined with Standard-of-Care Antibiotics against Cystic Fibrosis Pathogens

Biomedicines, 2023
Cystic fibrosis (CF) is a common life-shortening genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
Qingquan Chen, Marleini Ilanga, Sabona B. Simbassa, Bhagath Chirra, Kush N. Shah, Carolyn L. Cannon   +5 more
doaj   +1 more source

The forces driving clonal expansion of the HIV-1 latent reservoir

Virology Journal, 2020
Despite antiretroviral therapy (ART) which halts HIV-1 replication and reduces plasma viral load to clinically undetectable levels, viral rebound inevitably occurs once ART is interrupted.
Runxia Liu, Francesco R. Simonetti, Ya-Chi Ho   +2 more
doaj   +1 more source

SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX

eLife, 2022
To mount a protective response to infection while preventing hyperinflammation, gene expression in innate immune cells must be tightly regulated. Despite the importance of pre-mRNA splicing in shaping the proteome, its role in balancing immune outcomes ...
Allison R Wagner, Chi G Weindel, Kelsi O West, Haley M Scott, Robert O Watson, Kristin L Patrick   +5 more
doaj   +1 more source

Microbial genome sequencing and pathogenesis

Current Opinion in Microbiology, 1998
The year 1997 saw the publication of the complete nucleotide sequence of Helicobacter pylori and Escherichia coli. It is conceivable that the complete nucleotide sequence for all the major human bacterial pathogens will be available by the end of the century. Database alignments have been used to ascribe the putative functions of open reading frames in
Tang, C., Hood, D., Moxon, E.
openaire   +3 more sources