Results 31 to 40 of about 183,249 (254)

Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine [PDF]

, 2009
BACKGROUND: Variations in the composition of the human intestinal microbiota are linked to diverse health conditions. High-throughput molecular technologies have recently elucidated microbial community structure at much higher resolution than was ...
Vos, W.M., de, Willem M de Vos, O\u27Toole, Paul W., Smidt, H., O'Sullivan, O., Janne Nikkilä, Claesson Marcus J., de Vos Willem M., Hauke Smidt, O'Sullivan, Orla, Marchesi, Julian Roberto, O\u27Sullivan, Orla, Ross R. Paul, Smidt, Hauka, Ross, R. Paul, Ross, R. P., Paul W O'Toole, Wang, Qiong, Orla O'Sullivan, O'Sullivan Orla, de Vos, W.M., Qiong Wang, Nikkilä Janne, O'Toole, Paul W., Claesson, M.J., Marchesi, J.R., O'Toole, P.W., Claesson, Marcus J., O'Toole, P. W., Wang, Q., de Vos, Willem M., Claesson, M. J., Julian R Marchesi, O'Toole Paul W., Marchesi, Julian R., Smidt, Hauke, Ross, R.P., Smidt Hauke, Nikkila, Janne, R Paul Ross, Marchesi Julian R., Ross, R Paul, Wang Qiong, De Vos, W. M., Nikkilä, J., Marcus J Claesson   +45 more
core   +1 more source

Synergistic Antimicrobial Effects of Ibuprofen Combined with Standard-of-Care Antibiotics against Cystic Fibrosis Pathogens

Biomedicines, 2023
Cystic fibrosis (CF) is a common life-shortening genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
Qingquan Chen, Marleini Ilanga, Sabona B. Simbassa, Bhagath Chirra, Kush N. Shah, Carolyn L. Cannon   +5 more
doaj   +1 more source

Using microbial metalo-aminopeptidases as targets in human infectious diseases [PDF]

, 2021
Several microbial metalo-aminopeptidases are emerging as novel targets for the treatment of human infectious diseases. Some of them are well validated as targets and some are not; some are essential enzymes and others are important for virulence and ...
Maikel González-Matos, Jorge González-Bacerio, Maikel Izquierdo, Mirtha Elisa Aguado, Maday Alonso del Rivero, Ana C. Varela   +5 more
core   +1 more source

The forces driving clonal expansion of the HIV-1 latent reservoir

Virology Journal, 2020
Despite antiretroviral therapy (ART) which halts HIV-1 replication and reduces plasma viral load to clinically undetectable levels, viral rebound inevitably occurs once ART is interrupted.
Runxia Liu, Francesco R. Simonetti, Ya-Chi Ho   +2 more
doaj   +1 more source

Microbial synthesized cadmium oxide nanoparticles induce oxidative stress and protein leakage in bacterial cells

, 2020
The bactericidal activity of metal oxide nanoparticles (NPs) offers extensive opportunities in bioengineering and biomedicines. Bioengineered transition metals used in various forms against lethal microbes. In this study, Cadmium Oxide nanoparticles (CdO-
Azam, Zara, Zaman, Wajid, Irfan, Mian Muhammad, Ayaz, Asma, Nasar, Muhammad Qasim, Saqib, Saddam, Qureshi, Zeeshan, Ullah, Fazal, Younas, Muhammad, Arshad, Bushra, Bahadur, Saraj, Hussain, Sajjad   +11 more
core   +1 more source

SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX

eLife, 2022
To mount a protective response to infection while preventing hyperinflammation, gene expression in innate immune cells must be tightly regulated. Despite the importance of pre-mRNA splicing in shaping the proteome, its role in balancing immune outcomes ...
Allison R Wagner, Chi G Weindel, Kelsi O West, Haley M Scott, Robert O Watson, Kristin L Patrick   +5 more
doaj   +1 more source

Type 3 secretion system as an anti-Pseudomonal target

, 2021
Type 3 secretion systems (T3SSs) are a series of mechanisms involved in bacterial pathogenesis. While Pseudomonas aeruginosa only possess one T3SS, it plays a key role in the virulence of P. aeruginosa virulence.
Horna G., Ruiz J.
core   +1 more source

S9.6-based hybrid capture immunoassay for pathogen detection

Scientific Reports, 2023
The detection of pathogens is critical for clinical diagnosis and public health surveillance. Detection is usually done with nucleic acid-based tests (NATs) and rapid antigen tests (e.g., lateral flow assays [LFAs]).
Ankur Bothra, Megan L. Perry, Elena Wei, Mahtab Moayeri, Qian Ma, Marco A. Biamonte, Marina Siirin, Stephen H. Leppla   +7 more
doaj   +1 more source

The role of host and microbial factors in the pathogenesis of pneumococcal bacteraemia arising from a single bacterial cell bottleneck. [PDF]

, 2014
The pathogenesis of bacteraemia after challenge with one million pneumococci of three isogenic variants was investigated. Sequential analyses of blood samples indicated that most episodes of bacteraemia were monoclonal events providing compelling ...
Gianni Pozzi, U. Koedel (7682816), Antonio Vivi, Braccini, T., Tassini, Maria, Vivi, Antonio, Rooijen, Nico van, Ricci, Susanna, Vivi, A., E. R. Moxon (7583117), Leonarda Colomba, E. Richard Moxon (6704), Maria Tassini, Furi, L., Peter W. Andrew (153608), Braccini, Tiziana, E Richard Moxon, Leonarda Colomba (177832), M. Tassini (7697396), Ricci, S., Moxon, E. Richard, T. Braccini (7682810), Koedel, U., Andrea Pammolli, Antonio Vivi (540384), Nico van Rooijen (4110211), A. S. Manso (7697387), Marco R Oggioni, L. Colomba (7697384), Pozzi, G., A. Gerlini (7697381), Marco R. Oggioni, Susanna Ricci, Colomba, L., Gianni Pozzi (26718), Colomba, Leonarda, Wang, Bo, Andrew, P.W., Oggioni, Marco R., Maria Tassini (540385), E. Richard Moxon, Tiziana Braccini (540381), Marco R. Oggioni (131416), Manso, Ana Sousa, Ana Sousa Manso (540382), Oggioni, M.R., M. R. Oggioni (7619033), Bo Wang, N. van Rooijen (7697399), Alice Gerlini (540379), van Rooijen, N., Tassini, M., Koedel, Uwe, Alice Gerlini, Bo Wang (86769), Moxon, E.R., Susanna Ricci (26719), G. Pozzi (7629911), Pammolli, Andrea, Peter W. Andrew, Pozzi, Gianni, Peter W Andrew, Ana Sousa Manso, P. W. Andrew (7607321), Nico van Rooijen, A. Vivi (7697393), Uwe Koedel (263360), Gerlini, Alice, Manso, A.S., Andrew, Peter W., S. Ricci (7682807), Uwe Koedel, Gerlini, A., Pammolli, A., Wang, B., A. Pammolli (7697390), Andrea Pammolli (540383), L. Furi (7636547), Leonardo Furi, Tiziana Braccini, Leonardo Furi (540380), Furi, Leonardo   +81 more
core   +1 more source

Multiple Signals Govern Utilization of a Polysaccharide in the Gut Bacterium Bacteroides thetaiotaomicron

mBio, 2016
The utilization of simple sugars is widespread across all domains of life. In contrast, the breakdown of complex carbohydrates is restricted to a subset of organisms.
Nathan D. Schwalm, Guy E. Townsend, Eduardo A. Groisman   +2 more
doaj   +1 more source