Results 21 to 30 of about 174,422 (248)
International Journal of Health Sciences and Research, 2021 For a pathogenic microbe to cause disease in a susceptible host, it must gain access to that host first. The pathogenicity of a microbe is determined by the virulence factors alongside other innate mechanisms. Apart from the initiation of infection, these virulence factors also enable the pathogenic microorganism to survive in the new environment ...
openaire +2 more sources
mBio, 2020 Microbial colonization of the mammalian gut is largely ascribed to the ability to utilize nutrients available in that environment. To understand how beneficial microbes establish a relationship with their hosts, it is crucial to determine what other ...
Guy E. Townsend +6 more
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npj Vaccines, 2023 Staphylococcus aureus infections are a major public health issue, and a vaccine is urgently needed. Despite a considerable promise in preclinical models, all vaccines tested thus far have failed to protect humans against S. aureus. Unlike laboratory mice,
Omid Teymournejad +4 more
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Control of CD4+ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase
Signal Transduction and Targeted Therapy, 2023 CD4+ T cells, particularly IL-17-secreting helper CD4+ T cells, play a central role in the inflammatory processes underlying autoimmune disorders. Eukaryotic Elongation Factor 2 Kinase (eEF2K) is pivotal in CD8+ T cells and has important implications in ...
Hao-Yun Peng +9 more
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Viruses, 2021 More than 50% of the HIV-1 latent reservoir is maintained by clonal expansion. The clonally expanded HIV-1-infected cells can contribute to persistent nonsuppressible low-level viremia and viral rebound.
Yang-Hui Jimmy Yeh +3 more
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Valganciclovir as Add-On to Standard Therapy in Secondary Glioblastoma
Microorganisms, 2020 Patients with glioblastoma have a very poor prognosis despite aggressive therapeutic strategies. Cytomegalovirus has been detected in >90% of glioblastoma tumors.
Giuseppe Stragliotto +3 more
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Microbiology Spectrum, 2023 Individuals with cystic fibrosis (CF) suffer from frequent and recurring microbial airway infections. The Gram-negative bacterium Pseudomonas aeruginosa is one of the most common organisms isolated from CF patient airways. P.
Courtney E. Chandler +4 more
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Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing
Pathogens, 2021 Our understanding of how the host immune system thwarts bacterial evasive mechanisms remains incomplete. Here, we show that host protease neutrophil elastase acts on Acinetobacter baumannii and Pseudomonas aeruginosa to destroy factors that prevent serum-
Shaorong Chen +6 more
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Alternate subunit assembly diversifies the function of a bacterial toxin
Nature Communications, 2019 Salmonella Typhi produces the typhoid toxin. Here, Fowler et al. show that S. Typhi produces two forms of typhoid toxin that are differentially regulated and display different trafficking properties and different effects when administered to laboratory ...
Casey C. Fowler +4 more
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Frontiers in Cellular and Infection Microbiology, 2023 IntroductionWater distribution systems in hotels have been related to outbreaks caused by Legionella spp. Certain measures, including disinfection by chlorination, maintaining increased temperatures are usually undertaken to prevent Legionella outbreaks.
Dimosthenis Chochlakis +10 more
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