Results 51 to 60 of about 641,669 (159)
Viral rhodopsins 1 are an unique family of light-gated cation channels
Nature Communications, 2020 Nucleocytoplasmic Large DNA Viruses (NCLDV) that infect algae encode two distinct families of microbial rhodopsins. Here, the authors characterise two proteins form the viral rhodopsin group 1 OLPVR1 and VirChR1, present the 1.4 Å crystal structure of ...
Dmitrii Zabelskii +33 more
doaj +1 more source
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels
, 2022 Many organisms sense light using rhodopsins, photoreceptive proteins containing a retinal chromophore. Here we report the discovery, structure and biophysical characterization of bestrhodopsins, a microbial rhodopsin subfamily from marine unicellular ...
Konno, Masae +63 more
core +1 more source
Automatic Rhodopsin Modeling with Multiple Protonation Microstates [PDF]
, 2023 Automatic Rhodopsin Modeling (ARM) is a simulation protocol providing QM/MM models of rhodopsins, capable of reproducing experimental electronic absorption and emission trends.
Gustavo, Cardenas +9 more
core +2 more sources
Proton transfer pathway in anion channelrhodopsin-1
eLife, 2021 Anion channelrhodopsin from Guillardia theta (GtACR1) has Asp234 (3.2 Å) and Glu68 (5.3 Å) near the protonated Schiff base. Here, we investigate mutant GtACR1s (e.g., E68Q/D234N) expressed in HEK293 cells.
Masaki Tsujimura +4 more
doaj +1 more source
Applications and challenges of rhodopsin-based optogenetics in biomedicine
Frontiers in Neuroscience, 2022 Optogenetics is an emerging bioengineering technology that has been rapidly developed in recent years by cross-integrating optics, genetic engineering, electrophysiology, software control, and other disciplines.
Hanci Zhang +9 more
doaj +1 more source
Rhodopsin phylogenetics with Comchoano
, 2022 #rhodopsin alignment, fasta file untrimmedrhodopsin_alignment_mafft.w.gtdb.0.99.ordered.best.hits.and.ubas.and.changjae.fa.list.fa#rhodopsin alignment, fasta file trimmedrhodopsin_trimmed_alignment_trimal.mafft.w.gtdb.0.99.ordered.best.hits.and.ubas.and ...
David Needham (757445)
core +1 more source
Recent advances in engineering microbial rhodopsins for optogenetics [PDF]
Current Opinion in Structural Biology, 2015 Protein engineering of microbial rhodopsins has been successful in generating variants with improved properties for applications in optogenetics. Members of this membrane protein family can act as both actuators and sensors of neuronal activity. Chimeragenesis, structure-guided mutagenesis, and directed evolution have proven effective strategies for ...
R Scott McIsaac +2 more
openaire +4 more sources
Prepartum Heat Stress Dysregulates Immune Resilience in Postpartum Dairy Cows
The FASEB Journal, Volume 40, Issue 20, 31 October 2026.Increasing environmental temperatures pose a major challenge to animal welfare by inducing heat stress and increasing the incidence of disease. Immune resilience is essential for maintaining animal health; however, the mechanisms linking heat stress to immune dysfunction and disease remain unclear.
Arslan Tariq +10 more
wiley +1 more source
Exploratory experimentation and scientific practice: Metagenomics and the proteorhodopsin case [PDF]
, 2008 Exploratory experimentation and high-throughput molecular biology appear to have considerable affinity for each other. Included in the latter category is metagenomics, which is the DNA-based study of diverse microbial communities from a vast range of non-
O'Malley, Maureen
core
Color-tuning of natural variants of heliorhodopsin
Scientific Reports, 2021 Microbial rhodopsins are distributed through many microorganisms. Heliorhodopsins are newly discovered but have an unclear function. They have seven transmembrane helices similar to type-I and type-II rhodopsins, but they are different in that the N ...
Se-Hwan Kim +6 more
doaj +1 more source