While our genomes are essentially static, our microbiomes are inherently dynamic. The microbial communities we harbor in our bodies change throughout our lives due to many factors, including maturation during childhood, alterations in our diets, travel, illnesses, and medical treatments.
openaire +3 more sources
Bayesian Modeling of Microbiome Data for Differential Abundance Analysis [PDF]
The advances of next-generation sequencing technology have accelerated study of the microbiome and stimulated the high throughput profiling of metagenomes. The large volume of sequenced data has encouraged the rise of various studies for detecting differentially abundant taxonomic features across healthy and diseased populations, with the ultimate goal
arxiv
Human microbiome: take-home lesson on growth promoters? [PDF]
Didier Raoult
openalex +1 more source
Log-Contrast Regression with Functional Compositional Predictors: Linking Preterm Infant's Gut Microbiome Trajectories to Neurobehavioral Outcome [PDF]
The neonatal intensive care unit (NICU) experience is known to be one of the most crucial factors that drive preterm infant's neurodevelopmental and health outcomes. It is hypothesized that stressful early life experience of very preterm neonate is imprinting gut microbiome by the regulation of the so-called brain-gut axis, and consequently, certain ...
arxiv
A core gut microbiome in obese and lean twins [PDF]
Peter J. Turnbaugh+14 more
openalex +1 more source
Inference of Dynamic Regimes in the Microbiome [PDF]
Many studies have been performed to characterize the dynamics and stability of the microbiome across a range of environmental contexts [Costello et al., 2012, Faust et al., 2015]. For example, it is often of interest to identify time intervals within which certain subsets of taxa have an interesting pattern of behavior.
arxiv
Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome [PDF]
Peter J. Turnbaugh+3 more
openalex +1 more source
The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome [PDF]
David A. Sela+12 more
openalex +1 more source
Bayesian-Guided Generation of Synthetic Microbiomes with Minimized Pathogenicity [PDF]
Synthetic microbiomes offer new possibilities for modulating microbiota, to address the barriers in multidtug resistance (MDR) research. We present a Bayesian optimization approach to enable efficient searching over the space of synthetic microbiome variants to identify candidates predictive of reduced MDR.
arxiv
Application of Ecological Network Theory to the Human Microbiome [PDF]
James A. Foster+2 more
openalex +1 more source