Results 91 to 100 of about 463,232 (312)

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

The “normal” ocular microbiome and human eye health

, 2023
The ocular surface contains a unique microbiome that is exposed to the environment and is involved in the maintenance of ocular surface health and defense from disease.
Cavuoto, Kara, Galor, Anat, Patel, Veshesh   +2 more
core   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Drugging the microbiome

Journal of Experimental Medicine, 2020
Microbiome-modulating therapeutics have the potential to revolutionize medicine. Here, I discuss the challenges and opportunities inherent in creating new microbiome-based drugs.
openaire   +2 more sources

Extensive Unexplored Human Microbiome Diversity Revealed by Over 150,000 Genomes from Metagenomes Spanning Age, Geography, and Lifestyle

Cell, 2019
Summary The body-wide human microbiome plays a role in health, but its full diversity remains uncharacterized, particularly outside of the gut and in international populations.
Edoardo Pasolli, F. Asnicar, S. Manara, Moreno Zolfo, Nicolai Karcher, F. Armanini, F. Beghini, P. Manghi, Adrian Tett, P. Ghensi, M. Collado, Benjamin L. Rice, Casey DuLong, X. Morgan, C. Golden, C. Quince, C. Huttenhower, N. Segata   +17 more
semanticscholar   +1 more source

The microbiome of the Black Sea water column analyzed by shotgun and genome centric metagenomics

, 2021
Background: The Black Sea is the largest brackish water body in the world, although it is connected to the Mediterranean Sea and presents an upper water layer similar to some regions of the former, albeit with lower salinity and temperature.
Mehrshad, Maliheh,, Sveriges lantbruksuniversitet.   +1 more
core   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

Cell, 2019
SUMMARY Most patients diagnosed with resected pancreatic adenocarcinoma (PDAC) survive less than 5-years, but a minor subset survives longer. Here, we dissect the role of the tumor microbiota and the immune system in influencing long-term survival. Using
E. Riquelme, Yu Zhang, Liangliang Zhang, M. Montiel, Michelle Zoltan, W. Dong, P. Quesada, I. Sahin, Vidhi Chandra, Anthony Lucas, P. Scheet, Hanwen Xu, S. Hanash, Lei Feng, J. Burks, K. Do, Christine B. Peterson, D. Nejman, C. Tzeng, Michael P. Kim, C. Sears, N. Ajami, J. Petrosino, L. Wood, A. Maitra, R. Straussman, M. Katz, J. White, R. Jenq, J. Wargo, F. McAllister   +30 more
semanticscholar   +1 more source

Role of Bacillus subtilis exopolymeric genes in modulating rhizosphere microbiome assembly [PDF]

This article was originally published in Environmental Microbiome. The version of record is available at: https://doi.org/10.1186/s40793-024-00567-4. © The Author(s) 2024.
BAIS, H. P., Nishisaka, Caroline Sayuri, Mendes, Rodrigo, Bais, Harsh P., VENTURA, J. P., NISHISAKA, C. S., MENDES, R., Ventura, João Paulo   +7 more
core   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source