Results 101 to 110 of about 542,693 (329)

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes. [PDF]

, 2019
We demonstrated that an antibiotic cocktail (ABX)-perturbed gut microbiome is associated with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid precursor protein (APP)SWE /presenilin 1 (PS1)ΔE9 transgenic model of Aβ ...
Baufeld, Caroline, Butovsky, Oleg, Dodiya, Hemraj B, Gilbert, Jack A, Gottel, Neil, Kuntz, Thomas, Leibowitz, Jeffrey, Shaik, Shabana M, Sisodia, Sangram S, Zhang, Xiaoqiong, Zhang, Xulun   +10 more
core   +1 more source

Patterns of Oral Microbiota Diversity in Adults and Children: A Crowdsourced Population Study. [PDF]

, 2020
Oral microbiome dysbiosis has been associated with various local and systemic human diseases such as dental caries, periodontal disease, obesity, and cardiovascular disease.
Burcham, Zachary M, Comstock, Sarah S, Garneau, Nicole L, Genetics of Taste Lab Citizen Scientists, Knight, Rob, Metcalf, Jessica L, Tucker, Robin M   +6 more
core  

An Innovative “Tooth‐On‐Chip” Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue

Advanced Healthcare Materials, EarlyView.
This work presents a “tooth‐on‐chip” device that mimics dental pulp tissue. By co‐culturing key cell types, it recreates vascular networks, stem cell niches, the odontoblast/dentine interface, and trigeminal innervation. This innovative platform provides a unique model of dental pulp structure and physiology, with significant potential for accelerating
Alessandro Cordiale, Deborah Stanco, Roberta Visone, Bernd Stadlinger, Pierfrancesco Pagella, Marco Rasponi, Thimios A. Mitsiadis   +6 more
wiley   +1 more source

Structure, function and diversity of the healthy human microbiome [PDF]

, 2012
Studies of the human microbiome have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of this diversity remains unexplained, although diet, environment, host genetics and
Huttenhower, Curtis, Izard, Jacques
core   +1 more source

Do the Bugs in Your Gut Eat Your Memories? Relationship between Gut Microbiota and Alzheimer’s Disease

Brain Sciences, 2020
The human microbiota is composed of trillions of microbial cells inhabiting the oral cavity, skin, gastrointestinal (GI) tract, airways, and reproductive organs.
Emily M. Borsom, Keehoon Lee, Emily K. Cope   +2 more
doaj   +1 more source

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

Leuconostoc lactis strain APC 3969 produces a new variant of cyclic bacteriocin leucocyclicin Q and displays potent anti-Clostridium perfringens activity

Scientific Reports
Clostridium perfringens is an important foodborne pathogen that produces diverse toxins and is often associated with foodborne gastroenteritis. In this sense, novel biopreservatives with anti-C. perfringens activity are of interest.
Felipe Miceli de Farias, Maria Cecilia Soria, Paula M. O’Connor, Xiaohui Huang, Colin Buttimer, Eleni Kamilari, Aiswariya Deliephan, Daragh Hill, Oxana Fursenko, Jonathan Wiese, Lorraine Draper, Catherine Stanton, Colin Hill, R. Paul Ross   +13 more
doaj   +1 more source

Somatic cell count as an indicator of subclinical mastitis and increased inflammatory response in asymptomatic lactating women

Microbiology Spectrum
Subclinical mastitis is an asymptomatic inflammatory condition that can be difficult to define and diagnose. In the dairy industry, subclinical mastitis is diagnosed by milk somatic cell counts (SCCs) of ≥250,000 cells mL−1.
Angeliki Angelopoulou, Hugh M. B. Harris, Alicja K. Warda, Carol-Anne O'Shea, Aonghus Lavelle, C. Anthony Ryan, Eugene Dempsey, Catherine Stanton, Colin Hill, R. Paul Ross   +9 more
doaj   +1 more source

Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa

BMC Genomics, 2018
Background Faecalibacterium prausnitzii is a ubiquitous member of the human gut microbiome, constituting up to 15% of the total bacteria in the human gut. Substantial evidence connects decreased levels of F.
Cormac Brian Fitzgerald, Andrey N. Shkoporov, Thomas D. S. Sutton, Andrei V. Chaplin, Vimalkumar Velayudhan, R. Paul Ross, Colin Hill   +6 more
doaj   +1 more source