Results 71 to 80 of about 691,309 (371)

MedZIM: Mediation analysis for Zero-Inflated Mediators with applications to microbiome data

, 2020
The human microbiome can contribute to the pathogenesis of many complex diseases such as cancer and Alzheimer's disease by mediating disease-leading causal pathways.
Christensen, Brock C., Coker, Modupe O., Datta, Susmita, Gharaibeh, Raad Z., Hoen, Anne G., Jobin, Christian, Karagas, Margaret R., Li, Zhigang, Liyanage, Janaka S. S., Madan, Juliette C., O'Malley, A. James, Wu, Quran   +11 more
core   +1 more source

Utilization of Pyrosequencing to Monitor the Microbiome Dynamics of Probiotic Treated Poultry (Gallus gallus domesticus) during Downstream Poultry Processing [PDF]

, 2017
Antibiotic growth promoters that have been historically employed to control pathogens and increase the rate of animal development for human consumption are currently banned in many countries.
Bray, Joey, Clack, Beatrice, Guttala, Vamsy Priya, Medrano, Enrique G.   +3 more
core   +3 more sources

Lung microbiome: new insights into the pathogenesis of respiratory diseases

Signal Transduction and Targeted Therapy
The lungs were long thought to be sterile until technical advances uncovered the presence of the lung microbial community. The microbiome of healthy lungs is mainly derived from the upper respiratory tract (URT) microbiome but also has its own ...
Ruomeng Li, Jing Li, Xikun Zhou
semanticscholar   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

The oral microbiome

Emerging Topics in Life Sciences, 2017
The human microbiome is receiving a great deal of attention as its role in health and disease becomes ever more apparent. The oral microbiome, perhaps due to the ease with which we can obtain samples, is arguably the most well-studied human microbiome to date.
Shaw, LP, Smith, AM, Roberts, AP
openaire   +4 more sources

Plant domestication shapes rhizosphere microbiome assembly and metabolic functions

Microbiome, 2023
Background The rhizosphere microbiome, which is shaped by host genotypes, root exudates, and plant domestication, is crucial for sustaining agricultural plant growth.
Hong Yue, Wenjie Yue, Shuo Jiao, Hyun Kim, Yong-Hwan Lee, G. Wei, S. Weining, Duntao Shu   +7 more
semanticscholar   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice [PDF]

, 2013
Background: Murine models are a crucial component of gut microbiome research. Unfortunately, a multitude of genetic backgrounds and experimental setups, together with inter-individual variation, complicates cross-study comparisons and a global ...
Brinkman, Brigitta, Cauwe, Benedicte, Garcia Yunta, Roberto, Hildebrand, Falk, Liston, Adrian, Nguyen, (Thi Loan Anh, Raes, Jeroen, Vandenabeele, Peter   +7 more
core   +3 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Clinical Translation of Microbiome Research in Alopecia Areata: A New Perspective?

Cosmetics, 2022
The continuous research advances in the microbiome field is changing clinicians’ points of view about the involvement of the microbiome in human health and disease, including autoimmune diseases such as alopecia areata (AA).
Fabio Rinaldi, Anna Trink, Angela Papale, Giammaria Giuliani, Daniela Pinto   +4 more
doaj   +1 more source