Results 71 to 80 of about 585,088 (321)

Clinical Translation of Microbiome Research in Alopecia Areata: A New Perspective?

Cosmetics, 2022
The continuous research advances in the microbiome field is changing clinicians’ points of view about the involvement of the microbiome in human health and disease, including autoimmune diseases such as alopecia areata (AA).
Fabio Rinaldi, Anna Trink, Angela Papale, Giammaria Giuliani, Daniela Pinto   +4 more
doaj   +1 more source

MedZIM: Mediation analysis for Zero-Inflated Mediators with applications to microbiome data

, 2020
The human microbiome can contribute to the pathogenesis of many complex diseases such as cancer and Alzheimer's disease by mediating disease-leading causal pathways.
Christensen, Brock C., Coker, Modupe O., Datta, Susmita, Gharaibeh, Raad Z., Hoen, Anne G., Jobin, Christian, Karagas, Margaret R., Li, Zhigang, Liyanage, Janaka S. S., Madan, Juliette C., O'Malley, A. James, Wu, Quran   +11 more
core   +1 more source

A simple novel device for air sampling by electrokinetic capture. [PDF]

, 2015
BackgroundA variety of different sampling devices are currently available to acquire air samples for the study of the microbiome of the air. All have a degree of technical complexity that limits deployment.
Frazier, Angel, Gandhi, Prasanthi, Gilbert, Jack A, Gordon, Julian, Hampton-Marcell, Jarrad, Shekhawat, Gajendra   +5 more
core   +3 more sources

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Microbial regulation of microRNA expression in the amygdala and prefrontal cortex

Microbiome, 2017
Background There is growing evidence for a role of the gut microbiome in shaping behaviour relevant to many psychiatric and neurological disorders.
Alan E. Hoban, Roman M. Stilling, Gerard M. Moloney, Rachel D. Moloney, Fergus Shanahan, Timothy G. Dinan, John F. Cryan, Gerard Clarke   +7 more
doaj   +1 more source

TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells

Cell Death and Disease, 2021
Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes within these networks and both are associated with disruption of gut ...
Jerzy A. Woznicki, Nisha Saini, Peter Flood, Subhasree Rajaram, Ciaran M. Lee, Panagiota Stamou, Agnieszka Skowyra, Milan Bustamante-Garrido, Karine Regazzoni, Nyree Crawford, Simon S. McDade, Daniel B. Longley, Pedro Aza-Blanc, Fergus Shanahan, Syed A. Zulquernain, Jane McCarthy, Silvia Melgar, Bradford L. McRae, Ken Nally   +18 more
doaj   +1 more source

Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects

Advanced Healthcare Materials, EarlyView.
Bacterial infection is a major driver of delayed wound healing and postsurgical readmissions; with rising antibiotic resistance, solid peroxide–releasing biomaterials offer sustained delivery of ROS/O2 for antimicrobial control and microenvironmental modulation.
Ayden Watt, Chably Rachella, Charlotte Jaloux, Joshua Vorstenbosch, Adam Hart, Michael Tanzer, Geraldine Merle, Jake Barralet   +7 more
wiley   +1 more source

Characterization of GH2 and GH42 β-galactosidases derived from bifidobacterial infant isolates

AMB Express, 2019
Bifidobacteria are among the first and most abundant bacterial colonizers of the gastrointestinal tract of (breast-fed) healthy infants. Their success of colonising the infant gut is believed to be, at least partly, due to their ability to metabolize ...
Valentina Ambrogi, Francesca Bottacini, Joyce O’Sullivan, Mary O’Connell Motherway, Cao Linqiu, Barry Schoemaker, Margriet Schoterman, Douwe van Sinderen   +7 more
doaj   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter Lange, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source