Results 61 to 70 of about 376,828 (315)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

One Health, One Microbiome [PDF]

One Health is a concept and framework for addressing the interconnected nature of humans, animals and their environments to improve the health and wellbeing of all three, along with added social and financial benefits.
Zinsstag, Jakob, Yersin, Simon, Vonaesch, Pascale, Lanker, Kayla C, Muhummed, Abdifatah M   +4 more
core   +1 more source

Identification of robust and generalizable biomarkers for microbiome-based stratification in lifestyle interventions [PDF]

, 2023
Background A growing body of evidence suggests that the gut microbiota is strongly linked to general human health. Microbiome-directed interventions, such as diet and exercise, are acknowledged as a viable and achievable strategy for preventing disorders
Aimin Xu, Siliceo, Sara Leal, Ni, Yueqiong, Henrik B. Nielsen, Ni, YQ, Jiarui Chen, Panagiotou, Gianni, Xu, AM, Panagiotou, G, Siliceo, SL, Chen, JR, Yueqiong Ni, Gianni Panagiotou, Chen, Jiarui, Xu, Aimin, Sara Leal Siliceo, Nielsen, Henrik B., Nielsen, HB   +17 more
core   +1 more source

Stenoparib, an Inhibitor of Cellular Poly(ADP-Ribose) Polymerase, Blocks Replication of the SARS-CoV-2 and HCoV-NL63 Human Coronaviruses In Vitro

mBio, 2021
New therapeutics are urgently needed in the fight against COVID-19. Repurposing drugs that are either already approved for human use or are in advanced stages of the approval process can facilitate more rapid advances toward this goal.
Nathan E. Stone, Sierra A. Jaramillo, Ashley N. Jones, Adam J. Vazquez, Madison Martz, Lora M. Versluis, Marlee O. Raniere, Haley E. Nunnally, Katherine E. Zarn, Roxanne Nottingham, Ken R. Ng, Jason W. Sahl, David M. Wagner, Steen Knudsen, Erik W. Settles, Paul Keim, Christopher T. French   +16 more
doaj   +1 more source

Microbiome and asthma [PDF]

Asthma Research and Practice, 2018
The mucosal immune system is in constant communication with the vast diversity of microbes present on body surfaces. The discovery of novel molecular mechanisms, which mediate host-microbe communication, have highlighted the important roles played by microbes in influencing mucosal immune responses. Dendritic cells, epithelial cells, ILCs, T regulatory
Sokolowska, Milena, Frei, Remo, Lunjani, Nonhlanhla, Akdis, Cezmi A, O'Mahony, Liam   +4 more
openaire   +5 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

First encounters of the microbial kind: perinatal factors direct infant gut microbiome establishment [PDF]

, 2022
The human gut microbiome harbors a diverse range of microbes that play a fundamental role in the health and well-being of their host. The early-life microbiome has a major influence on human development and long-term health.
Ross, R. Paul, Linehan, Kevin, Stanton, Catherine, Ryan, C. Anthony, Dempsey, Eugene M.   +4 more
core  

Microbiome ethics, guiding principles for microbiome research, use and knowledge management [PDF]

, 2022
International audienceAbstract The overarching biological impact of microbiomes on their hosts, and more generally their environment, reflects the co-evolution of a mutualistic symbiosis, generating fitness for both.
Makhalanyane, Thulani P., Makhalanyane, Thulani, Sanz Herranz, Yolanda, Annelein Meisner, Makhalanyane, Thulani Peter, Maguin, Emmanuelle, Marie-Christine Champornier-Vergès, Charles, Trevor, Hauke Smidt, Yolanda Sanz, de Souza, Rafael Soares, Angela Sessitsch, Luca Cocolin, Lange, Lene, Wakelin, Steve, Champomier‑Vergès, Marie‑Christine, Cernava, Tomislav, de Souza, Rafael S., Gabriele Berg, Cotter, Paul, Kiran, George Seghal, Tanja Kostic, D’hondt, Kathleen, Lene Lange, Champomier-Vergès, Marie-Christine, George Seghal Kiran, Matthew Ryan, Berg, Gabriele, Michael Schloter, Kostic, Tanja, Cocolin, Luca, Schloter, Michael, Steve Wakelin, Sessitsch, Angela, de Souza, Rafael Soares Correa, Smidt, Hauke, Paul Cotter, Meisner, Annelein, Ryan, Matthew, Emmanuelle Maguin, Kathleen D´Hondt, Thulani Makhalanyane, Kiran, George S., Sanz, Yolanda, D'Hondt, Kathleen, Rafael Soares de Souza   +45 more
core   +1 more source

Microbiome and Gluten [PDF]

Annals of Nutrition and Metabolism, 2015
Celiac disease (CD) is a frequent chronic inflammatory enteropathy caused by gluten in genetically predisposed individuals that carry disease susceptibility genes (HLA-DQ2/8). These genes are present in about 30-40% of the general population, but only a small percentage of carriers develops CD.
openaire   +2 more sources

The cancer microbiome [PDF]

Nature Reviews Cancer, 2019
Collectively known as the microbiota, the commensal bacteria and other microorganisms that colonize the epithelial surfaces of our body have been shown to produce small molecules and metabolites that have both local and systemic effects on cancer onset, progression and therapy response.
Eran Elinav, Wendy S. Garrett, Giorgio Trinchieri, Jennifer Wargo   +3 more
openaire   +2 more sources