Results 101 to 110 of about 347,894 (267)

B vitamins intake and cancer risk: a structured narrative review of evidence on riboflavin, pyridoxine, cobalamin and folate

Pathology and Oncology Research
BackgroundB vitamins play key roles in one-carbon metabolism, DNA synthesis and methylation, and redox regulation. Their potential association with cancer risk remains debated due to heterogeneous findings and methodological limitations across studies ...
Alexander Bertuccioli, Alexander Bertuccioli, Chiara Maria Palazzi, Irene Asia Massaro, Massimiliano Cazzaniga, Ilaria Cavecchia, Maria Rosaria Matera, Valentina Biagioli, Luca Imperatori, Francesco Di Pierro, Francesco Di Pierro, Francesco Di Pierro, Annalisa Belli   +12 more
doaj   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

High-throughput workflow for cultivation and characterization of gut microbiota strains with anti-inflammatory properties and metabolite signature associated with gut-brain communication

Scientific Reports
The gut microbiota is deeply interconnected with the brain, a phenomenon often referred to as the gut-brain axis. Dysfunction in the microbiota-gut-brain axis can cause various neurological and psychiatric disorders associated with chronic inflammation ...
Jelena Đokić, Miroslav Dinić, Svetlana Soković Bajić, Aleksandar Bisenić, Hristina Mitrović, Stefan Jakovljević, Dušan Radojević, Emilija Brdarić, Jovanka Lukić, Milica Živković, Maja Tolinački, Amarela Terzić-Vidojević, Nataša Golić   +12 more
doaj   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Discovery and characterization of Christensenella hongkongensis as a novel bacterium in the adenoma-carcinoma progression

Journal of Translational Medicine
Background Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide and commonly starts from a pre-cancerous stage. This study aimed to identify potential fecal bacterial candidates associated with progression of CRC from the adenoma ...
Wenqing Zhang, Qi Su, Haiyun Shi, Yang Sun, Xiaobo Li, Mengbin Li, Hui Wang, Jun Yu, Nathalie Wong, Francis Ka Leung Chan, Jingwan Zhang, Siew Chien Ng   +11 more
doaj   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Microbiota be nimble [PDF]

EBioMedicine, 2019
Kozyrskyj, Anita L., Bourque, Stephane L., Ospina, Maria B.   +2 more
openaire   +2 more sources

Fecal microbiota transplantation improves bile acid malabsorption in patients with inflammatory bowel disease: results of microbiota and metabolites from two cohort studies

BMC Medicine
Background Bile acid malabsorption (BAM) or bile acid diarrhea (BAD) complicates more than 30% of Crohn’s disease (CD), yet no non-invasive biomarker reliably identifies patients who will benefit from fecal microbiota transplantation (FMT).
Gaochen Lu, Sheng Zhang, Rui Wang, Xia Wu, Yaoyao Chen, Quan Wen, Bota Cui, Faming Zhang, Pan Li   +8 more
doaj   +1 more source

The Role of Gut Microbiota in Insomnia: A Systematic Review of Case–Control Studies

Life
Background: Insomnia is one of the most prevalent health concerns and has a major impact on human health and quality of life. Increasing evidence indicates the gut microbiota’s role in sleep regulation through the gut–brain axis.
Yun Wang, Suyi Xie, Sizhe Chen, Chenyu Li, Yeuk Lam Chan, Ngan Yin Chan, Yun Kwok Wing, Francis K. L. Chan, Qi Su, Siew C. Ng   +9 more
doaj   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source