Results 71 to 80 of about 347,894 (267)

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Early life fecal microbiota transplantation enhances fermentation potential by changing the microbial profiles in broiler chickens

Poultry Science
The early gut microbiota of broiler chickens plays a critical role in shaping physiological functions later in life. Broilers have a limited capacity to utilize dietary fiber at an early stage of life.
Haoran Zhao, Muhammad Zeeshan Akram, Luke Comer, Matthias Corion, Elena Fako, Nadia Everaert   +5 more
doaj   +1 more source

Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy

Advanced Science, EarlyView.
Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu   +9 more
wiley   +1 more source

Microbiota and autoimmunity

Japanese Journal of Clinical Immunology, 2014
The microbiota plays a fundamental role in the development and the maintenance of the host immune system. Since microbiota is important in the induction and the expansion of Th17 cells and regulatory T cells, growing evidence supports that microbiome affect the induction and the disease course of autoimmune disorders.
openaire   +3 more sources

Food Additives And Microbiota

Northern Clinics of Istanbul, 2019
The use of food additives in food production is inevitable in this modern world. Although only a safe amount of food additives is approved, their safety has always been questioned. To our knowledge, the effects of food additives on microbiota have not been investigated in a detailed manner in the literature so far.
Gültekin, Fatih, Öner, Manolya Eser, Savaş, Hasan Basri, Doğan, Bora   +3 more
openaire   +4 more sources

Age- and sex-related differences in early-life gut microbiota and intestinal physiology in broiler chickens

Journal of Animal Science and Biotechnology
Background Early-life sex identification technologies are making sex-specific management increasingly feasible in broiler production, yet limited information exists on how males and females differ in the development of their gut ecosystem.
Matthias Corion, Muhammad Zeeshan Akram, Ester Arévalo Sureda, Luke Comer, Jeroen Maertens, Natasja Smeets, Nadia Everaert   +6 more
doaj   +1 more source

Early gut microbiota transplantation in broiler chicks exerts effects on intestinal health depending on the donor’s microbial composition

Poultry Science
Fecal microbiota transplantation (FMT) is a promising strategy for modulating the gut microbiota to enhance broilers’ health. This study investigated the effects of FMT of broilers (FMT1), laying hens (FMT2), and broiler breeders (FMT3) as donor on the ...
Haoran Zhao, Muhammad Zeeshan Akram, Luke Comer, Matthias Corion, Elena Fako, Nadia Everaert   +5 more
doaj   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Sex-dependent effects of a high-fat diet on the hypothalamic response in mice

Biology of Sex Differences
Sex differences in rodent models of diet-induced obesity are still poorly documented, particularly regarding how central mechanisms vary between sexes in response to an obesogenic diet.
Virginie Dreux, Candice Lefebvre, Charles-Edward Breemeersch, Colin Salaün, Christine Bôle-Feysot, Charlène Guérin, Pierre Déchelotte, Alexis Goichon, Moïse Coëffier, Ludovic Langlois   +9 more
doaj   +1 more source

Gut: The gate and key to brain

Chinese Medical Journal
. Brain science is the frontier of modern science, and new advances have been made in brain-like designs and brain-computer interfaces to simulate or develop brain functions.
Xiaohan Zhang, Yunsheng Yang, Xiangxiang Pan   +2 more
doaj   +1 more source