Results 61 to 70 of about 574,054 (312)

Substratum‐Associated Microbiota [PDF]

Water Environment Research, 2016
This survey of literature on substratumassociated microbiota from 2016 includes highlights of research findings associated with algae, cyanobacteria, and bacteria from a variety of aquatic environments, but primarily freshwaters. It covers topics of relevance to the Water Environment Federation along with those of emerging or recent interest such as ...
Paula C. Furey, Sylvia S. Lee, Daniel L. Clemans   +2 more
openaire   +9 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Nutritional Interventions Targeting Gut Microbiota during Cancer Therapies

, 2021
The gut microbiome is increasingly being recognized for its influence on intestinal and extra-intestinal disorders such as cancer. Today, diet is the most studied environmental modulator of gut microbiota, capable of altering or improving it in terms of ...
Antonio Gasbarrini, Marco Cintoni, Marta Palombaro, Maria Cristina Mele, Pauline Raoul, Emanuele Rinninella, Gabriele Pulcini   +6 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Gut virome remodeling after fecal microbiota transplantation is associated with virus–bacteria co-variation and metabolic response in obesity and type 2 diabetes

Gut Microbes
Fecal microbiota transplantation (FMT) modifies gut bacterial composition and improves metabolic outcomes in subjects with obesity and type 2 diabetes (ObT2), but bacterial changes alone do not fully explain the heterogeneity in clinical response.
Hui Jiang, Ye Peng, Brian Lam, Keli Yang, Yu Lin, Joyce W. Y. Mak, Yee Kit Tse, Francis K. L. Chan, Zhilu Xu, Siew C. Ng   +9 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Evaluating the microbial diversity of an in vitro model of the human large intestine by phylogenetic microarray analysis [PDF]

, 2010
A high-density phylogenetic microarray targeting small subunit rRNA (SSU rRNA) sequences of over 1000 microbial phylotypes of the human gastrointestinal tract, the HITChip, was used to assess the impact of faecal inoculum preparation and operation ...
Vos, W.M., de, Smidt, H., Mirjana Rajilić-Stojanović, de Vos, Willem M., Rajilic-Stojanovic, M., Rajilić-Stojanović, Mirjana, Koen Venema, Maathuis, A., Hauke Smidt, Maathuis, Annet, Smidt, Hauke, Hans G. H. J. Heilig, Venema, Koen, Willem M. de Vos, Heilig, G.H.J., Annet Maathuis, Heilig, Hans G. H. J., Venema, K.   +17 more
core   +1 more source

Probiotic potential of Phocaeicola coprocola in modulating learning and memory behaviors in the honeybee model

Frontiers in Microbiology
IntroductionGut microbial therapy has emerged as a prominent research topic for brain function and disorders. The depletion of Phocaeicola coprocola has been reported in various brain-related conditions, suggesting its possible neuroprotective and ...
Mengqi Xu, Mengqi Xu, Xiaohan Zhang, Xiaohan Zhang, Xi Luo, Guanzhou Zhou, Guanzhou Zhou, Nana Zhang, Xiaoyan Chi, Xiaoyan Chi, Rongrong Ren, Lihua Peng, Gang Sun, Yunsheng Yang, Yunsheng Yang   +14 more
doaj   +1 more source

Antibiotics and probiotics impact gut antimicrobial resistance gene reservoir in COVID-19 patients

Gut Microbes, 2022
Dysbiosis of gut microbiota is well-described in patients with coronavirus 2019 (COVID-19), but the dynamics of antimicrobial resistance genes (ARGs) reservoir, known as resistome, is less known.
Qi Su, Qin Liu, Lin Zhang, Zhilu Xu, Chenyu Liu, Wenqi Lu, Jessica YL Ching, Amy Li, Joyce Wing Yan Mak, Grace Chung Yan Lui, Susanna So Shan Ng, Kai Ming Chow, David SC Hui, Paul KS Chan, Francis Ka Leung Chan, Siew C Ng   +15 more
doaj   +1 more source