Results 41 to 50 of about 544,602 (315)

Characterization of Exosporium Layer Variability of Clostridioides difficile Spores in the Epidemically Relevant Strain R20291

Frontiers in Microbiology, 2020
Clostridioides difficile is a Gram-positive anaerobic intestinal pathogenic bacterium and the causative agent of antibiotic-associated diarrhea. C. difficile spore is a dormant state which acts as a vehicle of transmission and infection. In C.
Marjorie Pizarro-Guajardo, Marjorie Pizarro-Guajardo, Paulina Calderón-Romero, Alba Romero-Rodríguez, Alba Romero-Rodríguez, Daniel Paredes-Sabja, Daniel Paredes-Sabja   +6 more
doaj   +1 more source

Alteration of Gut Microbiota in Carbapenem-Resistant Enterobacteriaceae Carriers during Fecal Microbiota Transplantation According to Decolonization Periods

, 2021
Fecal microbiota transplantation (FMT) has been suggested as an alternative therapeutic option to decolonize carbapenem-resistant Enterobacteriaceae (CRE).
Ki Tae Suk, Jin-Jae Lee, Heung-Jeong Woo, Bong-Soo Kim, Dongeun Yong, Dong Joon Kim, Seung Soon Lee   +6 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Production of germ-free mosquitoes via transient colonisation allows stage-specific investigation of host–microbiota interactions

Nature Communications, 2021
Germ-free mosquitoes generated with current methods exhibit developmental deficits. Here, the authors use genetically modified bacteria to allow complete decolonisation at any developmental stage of Aedes aegypti mosquitoes and show that bacteria support
Ottavia Romoli, Johan Claes Schönbeck, Siegfried Hapfelmeier, Mathilde Gendrin   +3 more
doaj   +1 more source

Metatranscriptome analysis of the human fecal microbiota reveals subject-specific expression profiles, with genes encoding proteins involved in carbohydrate metabolism being dominantly expressed [PDF]

, 2010
The human gastrointestinal (GI) tract provides home to a complex microbial community, collectively termed microbiota. Although major efforts have been made to describe the diversity and stability of the microbiota, functional studies have been largely ...
Vos, W.M., de, Kleerebezem, M., Smidt, H., Zoetendal, E.G., te Boekhorst, J., Hauke Smidt, Booijink, C.C.G.M., Erwin G. Zoetendal, Carien C. G. M. Booijink, Boekhorst, J., te, Michiel Kleerebezem, Jos Boekhorst, Willem M. de Vos, de Vos, W.M.   +13 more
core   +1 more source

Oral Microbiota of Children Is Conserved across Han, Tibetan and Hui Groups and Is Correlated with Diet and Gut Microbiota

, 2021
The oral microbiota can be affected by several factors; however, little is known about the relationship between diet, ethnicity and commensal oral microbiota among school children living in close geographic proximity.
Jing Huang, Huan Li, Xiaodan Huang, Feihong Ren, Tingyu Yang, Ke Liu, Siyu Chen, Danfeng Long   +7 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Honeybees fed D-galactose exhibit aging signs with changes in gut microbiota and metabolism

mSystems
Honeybees (Apis mellifera), as social insects, exhibit complex social behaviors and cognitive functions. The short lifespan and stable gut microorganisms of honeybees provide certain availability as a rapid and high-flux animal model for aging research ...
Guanzhou Zhou, Jiabin Hu, Mengqi Xu, Yiyuan Li, Ruqi Chang, Jiaqi Zeng, Wanyue Dan, Lihua Peng, Zikai Wang, Gang Sun, Fei Pan, Yunsheng Yang   +11 more
doaj   +1 more source

Antibiotics and probiotics impact gut antimicrobial resistance gene reservoir in COVID-19 patients

Gut Microbes, 2022
Dysbiosis of gut microbiota is well-described in patients with coronavirus 2019 (COVID-19), but the dynamics of antimicrobial resistance genes (ARGs) reservoir, known as resistome, is less known.
Qi Su, Qin Liu, Lin Zhang, Zhilu Xu, Chenyu Liu, Wenqi Lu, Jessica YL Ching, Amy Li, Joyce Wing Yan Mak, Grace Chung Yan Lui, Susanna So Shan Ng, Kai Ming Chow, David SC Hui, Paul KS Chan, Francis Ka Leung Chan, Siew C Ng   +15 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source