Results 1 to 10 of about 11,204 (224)

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure [PDF]

Advanced Science
Microcystin‐LR (MC‐LR) exacerbates metabolic dysfunction‐associated steatotic liver disease (MASLD) by inducing histopathological damage and lipid metabolism disorders.
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
doaj   +3 more sources

Effects of different doses of microcystin-LR exposure on gut development and the microbiota of Xenopus laevis tadpoles [PDF]

BMC Microbiology
Background Although the acute toxicity of microcystin-LR has been widely confirmed, its effects on aquatic organisms at environmental concentrations have not been systematically studied.
Jinjin Li, Yuanyuan Zhang, Jiajia Ni, Wenxuan Hou, Lei Huang, Hanping Pan, Chenxu Wang, Kaixin Wang, Shaoyuan Zuo, Jiahao Dong, Mingyu Zhang   +10 more
doaj   +2 more sources

Increased Prorenin Expression in the Kidneys May Be Involved in the Abnormal Renal Function Caused by Prolonged Environmental Exposure to Microcystin-LR [PDF]

Toxics
Toxic algae in eutrophic lakes produce cyanotoxic microcystins. Prior research on the effect of microcystin-LR in the kidney utilized intraperitoneal injections, which did not reflect natural exposure.
Yuuka Hitsuda, Yoshihito Koto, Hideaki Kawahara, Koichi Kurata, Keisuke Yoshikiyo, Kohji Nishimura, Ayumi Hashiguchi, Hideaki Maseda, Kunihiro Okano, Norio Sugiura, Kazuya Shimizu, Hidehisa Shimizu   +11 more
doaj   +2 more sources

Seasonal Rise in the Contents of Microcystin-LR and Odorous Substances Due to Cyanobacterial Blooms in a Drinking Water Reservoir Supplying Xinyang City, China [PDF]

Toxins
Cyanobacterial blooms have become a serious water pollution problem in many parts of the world, and the monitoring and study of the impacts of biotoxins on human health are of vital importance.
Wei Zhao, Yang Liu, Hua Li, Junguo Ma, Xiaoyu Li   +4 more
doaj   +2 more sources

Microcystin-LR in drinking water: An emerging role of mitochondrial-induced epigenetic modifications and possible mitigation strategies [PDF]

Toxicology Reports
Algal blooms are a serious menace to freshwater bodies all over the world. These blooms typically comprise cyanobacterial outgrowths that produce a heptapeptide toxin, Microcystin-LR (MC-LR). Chronic MC-LR exposure impairs mitochondrial-nuclear crosstalk,
Kashish Gupta, Nikita Soni, Ram Kumar Nema, Neelam Sahu, Rupesh K. Srivastava, Pooja Ratre, Pradyumna Kumar Mishra   +6 more
doaj   +2 more sources

Microcystin-LR incorporated into colonic cells through probenecid-sensitive transporters leads to upregulated MCP-1 expression induced by JNK activation

Toxicology Reports, 2022
Harmful algae that inhabit eutrophic lakes produce cyanotoxic microcystins. Therefore, the relationship between chronic exposure to microcystins via drinking water and organ disorders has been investigated.
Yoshihito Koto, Hideaki Kawahara, Koichi Kurata, Keisuke Yoshikiyo, Ayumi Hashiguchi, Kunihiro Okano, Norio Sugiura, Kazuya Shimizu, Hidehisa Shimizu   +8 more
doaj   +1 more source

Prior exposure to microcystin alters host gut resistome and is associated with dysregulated immune homeostasis in translatable mouse models

Scientific Reports, 2022
A strong association between exposure to the common harmful algal bloom toxin microcystin and the altered host gut microbiome has been shown. We tested the hypothesis that prior exposure to the cyanotoxin microcystin-LR may alter the host resistome.
Punnag Saha, Dipro Bose, Vitalii Stebliankin, Trevor Cickovski, Ratanesh K. Seth, Dwayne E. Porter, Bryan W. Brooks, Kalai Mathee, Giri Narasimhan, Rita Colwell, Geoff I. Scott, Saurabh Chatterjee   +11 more
doaj   +1 more source

First Report on Microcystin-LR Occurrence in Water Reservoirs of Eastern Cuba, and Environmental Trigger Factors

Toxins, 2022
The factors related to cyanotoxin occurrence and its social impact, with comprehension and risk perception being the most important issues, are not yet completely understood in the Cuban context. The objectives of this research were to determine the risk
José Carlos Rodríguez Tito, Liliana Maria Gomez Luna, Wim Noppe Noppe, Inaudis Alvarez Hubert   +3 more
doaj   +1 more source

Microcystin-LR does not induce alterations to transcriptomic or metabolomic profiles of a model heterotrophic bacterium. [PDF]

PLoS ONE, 2017
Microcystins are secondary metabolites produced by several freshwater, bloom-forming cyanobacterial species. Microcystin-producing cyanobacteria co-occur with a complex community of heterotrophic bacteria.
Robbie M Martin, Stephen P Dearth, Gary R LeCleir, Shawn R Campagna, Elizabeth M Fozo, Erik R Zinser, Steven W Wilhelm   +6 more
doaj   +1 more source

Early physiological and biochemical responses of rice seedlings to low concentration of microcystin-LR [PDF]

, 2013
Microcystin-leucine and arginine (microcystin- LR) is a cyanotoxin produced by cyanobacteria like Microcystis aeruginosa, and it’s considered a threat to water quality, agriculture, and human health.
Azevedo, Catarina, Azevedo, Joana, Campos, Alexandre, Osório, Hugo, Vasconcelos, Vítor   +4 more
core   +1 more source