Results 11 to 20 of about 11,325 (225)

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure [PDF]

Advanced Science
Microcystin‐LR (MC‐LR) exacerbates metabolic dysfunction‐associated steatotic liver disease (MASLD) by inducing histopathological damage and lipid metabolism disorders.
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
doaj   +3 more sources

Microcystin-LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity. [PDF]

Adv Sci (Weinh)
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Zhang S, Gao Q, Peng Y, Zhang H, Shen Q, Guo M, Gong Y, Chu L, Wu W, Wen Y, Cao W, Wang Y, Wang L.   +12 more
europepmc   +2 more sources

Effects of different doses of microcystin-LR exposure on gut development and the microbiota of Xenopus laevis tadpoles [PDF]

BMC Microbiology
Background Although the acute toxicity of microcystin-LR has been widely confirmed, its effects on aquatic organisms at environmental concentrations have not been systematically studied.
Jinjin Li, Yuanyuan Zhang, Jiajia Ni, Wenxuan Hou, Lei Huang, Hanping Pan, Chenxu Wang, Kaixin Wang, Shaoyuan Zuo, Jiahao Dong, Mingyu Zhang   +10 more
doaj   +2 more sources

Increased Prorenin Expression in the Kidneys May Be Involved in the Abnormal Renal Function Caused by Prolonged Environmental Exposure to Microcystin-LR [PDF]

Toxics
Toxic algae in eutrophic lakes produce cyanotoxic microcystins. Prior research on the effect of microcystin-LR in the kidney utilized intraperitoneal injections, which did not reflect natural exposure.
Yuuka Hitsuda, Yoshihito Koto, Hideaki Kawahara, Koichi Kurata, Keisuke Yoshikiyo, Kohji Nishimura, Ayumi Hashiguchi, Hideaki Maseda, Kunihiro Okano, Norio Sugiura, Kazuya Shimizu, Hidehisa Shimizu   +11 more
doaj   +2 more sources

Microcystin-LR in Primary Liver Cancers: An Overview [PDF]

Toxins, 2022
The cyanobacterial blooms produced by eutrophic water bodies have become a serious environmental issue around the world. After cellular lysing or algaecide treatment, microcystins (MCs), which are regarded as the most frequently encountered cyanobacterial toxins in fresh water, are released into water.
Shen Gu, Mingxuemei Jiang, Bo Zhang
openaire   +4 more sources

Microcystin-LR in drinking water: An emerging role of mitochondrial-induced epigenetic modifications and possible mitigation strategies [PDF]

Toxicology Reports
Algal blooms are a serious menace to freshwater bodies all over the world. These blooms typically comprise cyanobacterial outgrowths that produce a heptapeptide toxin, Microcystin-LR (MC-LR). Chronic MC-LR exposure impairs mitochondrial-nuclear crosstalk,
Kashish Gupta, Nikita Soni, Ram Kumar Nema, Neelam Sahu, Rupesh K. Srivastava, Pooja Ratre, Pradyumna Kumar Mishra   +6 more
doaj   +2 more sources

Seasonal Rise in the Contents of Microcystin-LR and Odorous Substances Due to Cyanobacterial Blooms in a Drinking Water Reservoir Supplying Xinyang City, China [PDF]

Toxins
Cyanobacterial blooms have become a serious water pollution problem in many parts of the world, and the monitoring and study of the impacts of biotoxins on human health are of vital importance.
Wei Zhao, Yang Liu, Hua Li, Junguo Ma, Xiaoyu Li   +4 more
doaj   +2 more sources

Assessing the combined toxicity of the natural toxins, aflatoxin B₁, fumonisin B₁ and microcystin-LR by high content analysis [PDF]

, 2018
As human co-exposure to natural toxins through food and water is inevitable, risk assessments to safeguard health are necessary. Aflatoxin B1 and fumonisin B1, frequent co-contaminants of maize and microcystin-LR, produced in freshwater by cyanobacteria ...
Elliott, Christopher T., Hajšlová, Jana, Krska, Rudolf, Meneely, Julie P.   +3 more
core   +1 more source

Immunohistochemical Localization of Microcystin-LR in the Liver of Mice: A Study on the Pathogenesis of Microcystin-LR-Induced Hepatotoxicity [PDF]

Toxicologic Pathology, 1998
The relationship between the intralobular sites of hepatotoxic injury and the distribution of microcystin-LR (MCLR), an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), was examined using an immunohistochemical method with a monoclonal antibody specific to MCLR on the livers of mice receiving a single ip injection of the MCLR.
T, Yoshida, Y, Makita, T, Tsutsumi, S, Nagata, F, Tashiro, F, Yoshida, M, Sekijima, S, Tamura, T, Harada, K, Maita, Y, Ueno   +10 more
openaire   +2 more sources

Associations between chlorophyll a and various microcystin-LR health advisory concentrations [version 1; referees: 1 approved, 2 approved with reservations]

F1000Research, 2016
Cyanobacteria harmful algal blooms (cHABs) are associated with a wide range of adverse health effects that stem mostly from the presence of cyanotoxins.
Jeffrey W. Hollister, Betty J. Kreakie
doaj   +1 more source