Oral Microcystin-LR Does Not Cause Hepatotoxicity in Pigs: Is the Risk of Microcystin-LR Overestimated? [PDF]
Exposure and Health, 2019 AbstractThe global increase of toxin-producing cyanobacteria poses a serious risk to humans. Many investigations have shown that the cyanotoxin microcystin-LR induces hepatotoxicity in rodents. However, many of these studies applied the toxin intraperitoneally or used high oral concentrations, leading to an unrealistically high bioavailability of the ...
Richard D. Welten +6 more
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A fluorescent-labeled microcystin-LR terbium cryptate
Journal of the Brazilian Chemical Society, 2006 A new fluorescent labeled compound of microcystin-LR with terbium cryptate was obtained by initial conjugation of microcystins-LR with aminoethanethiol followed by the reaction with the ester group of terbium cryptate.
Oliveira Eduardo J. A. +7 more
doaj +1 more source
Microcystin-LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity. [PDF]
Adv Sci (Weinh)MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Zhang S +12 more
europepmc +2 more sources
Determination of microcystin-LR, employing aptasensors [PDF]
Biosensors and Bioelectronics, 2018 Cyanobacteria produce toxins such as microcystin-LR (MC-LR), which are associated with potential hepatotoxicity in humans. The detection of cyanobacteria and their toxins in drinking water and sea food is therefore crucial. To date, methods such as high performance liquid chromatography (HPLC), protein phosphatase inhibition assay (PPIA), and Raman ...
Hasan Badie Bostan +7 more
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Microcystin-LR does not induce alterations to transcriptomic or metabolomic profiles of a model heterotrophic bacterium. [PDF]
PLoS ONE, 2017 Microcystins are secondary metabolites produced by several freshwater, bloom-forming cyanobacterial species. Microcystin-producing cyanobacteria co-occur with a complex community of heterotrophic bacteria.
Robbie M Martin +6 more
doaj +1 more source
Proteasome as a Molecular Target of Microcystin-LR [PDF]
Toxins, 2015 Proteasome degrades proteins in eukaryotic cells. As such, the proteasome is crucial in cell cycle and function. This study proved that microcystin-LR (MC-LR), which is a toxic by-product of algal bloom, can target cellular proteasome and selectively inhibit proteasome trypsin-like (TL) activity. MC-LR at 1 nM can inhibit up to 54% of the purified 20S
Zhu, Zhu, Zhang, Li, Shi, Guoqing
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Increasing Microcystis cell density enhances microcystin synthesis: a mesocosm study [PDF]
, 2012 An experimental protocol using mesocosms was established to study the effect of Microcystis sp. cell abundance on microcystin production. The mesocosms (55 L) were set up in a shallow eutrophic lake and received either no (control), low (to simulate a ...
Dietrich, Daniel R +7 more
core +1 more source
Immunohistochemical Localization of Microcystin-LR in the Liver of Mice: A Study on the Pathogenesis of Microcystin-LR-Induced Hepatotoxicity [PDF]
Toxicologic Pathology, 1998 The relationship between the intralobular sites of hepatotoxic injury and the distribution of microcystin-LR (MCLR), an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), was examined using an immunohistochemical method with a monoclonal antibody specific to MCLR on the livers of mice receiving a single ip injection of the MCLR.
T, Yoshida +10 more
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F1000Research, 2016 Cyanobacteria harmful algal blooms (cHABs) are associated with a wide range of adverse health effects that stem mostly from the presence of cyanotoxins.
Jeffrey W. Hollister, Betty J. Kreakie
doaj +1 more source
An overview of the toxic effect of potential human carcinogen Microcystin-LR on testis
Toxicology Reports, 2015 The worldwide occurrence of cyanobacterial blooms due to water eutrophication evokes extreme concerns. These blooms produce cyanotoxins which are hazardous to living organisms.
Yaqoob Lone +2 more
doaj +1 more source