Results 11 to 20 of about 114,699 (211)
Degradation of microcystin-LR by aquatic bacteria. [PDF]
, 2007 Microcystins are cyclic heptapeptide toxins produced by cyanobacteria. They are potentially a threat to human and domestic animals so are of worldwide interest. Microcystin-LR is stable in various environmental conditions.
Ghimire, Buddhi Sagar
core +8 more sources
Oral Microcystin-LR Does Not Cause Hepatotoxicity in Pigs: Is the Risk of Microcystin-LR Overestimated? [PDF]
Exposure and Health, 2019 The global increase of toxin-producing cyanobacteria poses a serious risk to humans. Many investigations have shown that the cyanotoxin microcystin-LR induces hepatotoxicity in rodents.
Elliott, Christopher T. +6 more
core +5 more sources
Oxidative stress biomarkers in Clarias gariepinus (Burchel, 1822) exposed to Microcystin-LR [PDF]
Beni-Suef University Journal of Basic and Applied Sciences, 2017 Stress levels inflicted by microcystin-LR extracted from Microcystis aeruginosa were assessed by estimating the effects on the oxidative stress biomarkers in the liver, muscle and gill tissues of Clarias gariepinus. Microcystin-LR was administered to the
Patrick Omoregie Isibor
doaj +3 more sources
Effects of microcystin-LR in isolated perfused rat kidney [PDF]
Brazilian Journal of Medical and Biological Research, 1999 Microcystin is a hepatotoxic peptide which inhibits protein phosphatase types 1 and 2A. The objective of the present study was to evaluate the physiopathologic effects of microcystin-LR in isolated perfused rat kidney.
A.C.L. Nobre +4 more
doaj +2 more sources
Microcystin-LR Induced Immunotoxicity in Mammals [PDF]
Journal of Toxicology, 2016 Microcystins are toxic molecules produced by cyanobacterial blooms due to water eutrophication. Exposure to microcystins is a global health problem because of its association with various other pathological effects and people all over the world are ...
Yaqoob Lone +2 more
doaj +3 more sources
Microcystin-LR Removal from Water via Enzymatic Linearization and Ultrafiltration [PDF]
Toxins, 2022 Microcystin-LR (MC-LR) is a toxin produced by cyanobacteria that can bloom in freshwater supplies. This study describes a new strategy for remediation of MC-LR that combines linearization of the toxin using microcystinase A, MlrA, enzyme with rejection ...
Abelline Fionah +6 more
doaj +2 more sources
Mitochondria a key role in microcystin-LR kidney intoxication [PDF]
Journal of Applied Toxicology, 2008 Microcystins (MCs) are a group of closely related cyclic heptapeptides produced by a variety of common cyanobacteria. These toxins have been implicated in both human and livestock mortality.
La-Salete, R. +9 more
core +5 more sources
A fluorescent-labeled microcystin-LR terbium cryptate [PDF]
Journal of the Brazilian Chemical Society, 2006 A new fluorescent labeled compound of microcystin-LR with terbium cryptate was obtained by initial conjugation of microcystins-LR with aminoethanethiol followed by the reaction with the ester group of terbium cryptate.
Oliveira Eduardo J. A. +7 more
doaj +2 more sources
Microcystin-LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity. [PDF]
Adv Sci (Weinh)MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Zhang S +12 more
europepmc +2 more sources
Determination of microcystin-LR, employing aptasensors [PDF]
Biosensors and Bioelectronics, 2018 Cyanobacteria produce toxins such as microcystin-LR (MC-LR), which are associated with potential hepatotoxicity in humans. The detection of cyanobacteria and their toxins in drinking water and sea food is therefore crucial. To date, methods such as high performance liquid chromatography (HPLC), protein phosphatase inhibition assay (PPIA), and Raman ...
Hasan Badie Bostan +7 more
openaire +2 more sources