Results 11 to 20 of about 11,204 (224)
Hepatotoxin microcystin-LR extraction optimization [PDF]
Journal of the Brazilian Chemical Society, 2009 Several cyanobacterial genera produce toxic secondary metabolites, the most well-known of which are the hepatotoxic microcystins (MCYSTs). Microcystin analyses in drinking water are a requirement of the Health Ministry (Regulation 518/2004) in Brazil ...
ALVES, Ivânio R. +5 more
core +4 more sources
Microcystin-LR Induced Immunotoxicity in Mammals [PDF]
Journal of Toxicology, 2016 Microcystins are toxic molecules produced by cyanobacterial blooms due to water eutrophication. Exposure to microcystins is a global health problem because of its association with various other pathological effects and people all over the world are ...
Yaqoob Lone +2 more
doaj +4 more sources
Haematology of Clarias gariepinus exposed to Microcystin-LR [PDF]
Beni-Suef University Journal of Basic and Applied Sciences, 2017 A static bioassay experiment was conducted by exposing Clarias gariepinus to 200 mg/L and 400m/L of MCLR solutions for 14 days and 28 days to assess the haematological impacts such as estimation of red blood cells, white blood cell and Thrombocytes ...
Isibor, Patrick Omoregie
core +4 more sources
Microcystin-LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity. [PDF]
Adv Sci (Weinh)MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Zhang S +12 more
europepmc +2 more sources
Determination of microcystin-LR, employing aptasensors [PDF]
Biosensors and Bioelectronics, 2018 Cyanobacteria produce toxins such as microcystin-LR (MC-LR), which are associated with potential hepatotoxicity in humans. The detection of cyanobacteria and their toxins in drinking water and sea food is therefore crucial. To date, methods such as high performance liquid chromatography (HPLC), protein phosphatase inhibition assay (PPIA), and Raman ...
Hasan Badie Bostan +7 more
openaire +2 more sources
Photorelease of microcystin-LR from resuspended sediments [PDF]
Harmful Algae, 2017 A series of ten photolysis experiments was conducted with sediments exposed to Microcystis sp. blooms to determine if sunlight is capable of mobilizing the biotoxin microcystin-LR (MC-LR) into the water column. There was a net photorelease of MC-LR in irradiated suspensions in all cases relative to dark controls, ranging from 0.4 to 192μgL-1g-1 into ...
Robert J, Kieber +6 more
openaire +2 more sources
Toxins, 2023 Microcystin can be present in variable concentrations, phases (dissolved and particulate), and structural forms (congeners), all which impact the toxicity and persistence of the algal metabolite.
Emily F. Pierce, Astrid Schnetzer
doaj +1 more source
Microcystin-LR in Primary Liver Cancers: An Overview. [PDF]
Toxins (Basel), 2022 The cyanobacterial blooms produced by eutrophic water bodies have become a serious environmental issue around the world. After cellular lysing or algaecide treatment, microcystins (MCs), which are regarded as the most frequently encountered cyanobacterial toxins in fresh water, are released into water.
Gu S, Jiang M, Zhang B.
europepmc +4 more sources
Assessing the combined toxicity of the natural toxins, aflatoxin B1, fumonisin B1 and microcystin-LR by high content analysis [PDF]
, 2018 As human co-exposure to natural toxins through food and water is inevitable, risk assessments to safeguard health are necessary. Aflatoxin B1 and fumonisin B1, frequent co-contaminants of maize and microcystin-LR, produced in freshwater by cyanobacteria ...
Elliott, Christopher T. +3 more
core +1 more source
F1000Research, 2016 Cyanobacteria harmful algal blooms (cHABs) are associated with a wide range of adverse health effects that stem mostly from the presence of cyanotoxins.
Jeffrey W. Hollister, Betty J. Kreakie
doaj +1 more source