Results 61 to 70 of about 34,690 (216)

Lysine in Combination With Estradiol Promote Dissemination of Estrogen Receptor Positive Breast Cancer via Upregulation of U2AF1 and RPN2 Proteins

Frontiers in Oncology, 2020
The majority of estrogen receptor positive (ER+) breast cancer (BC) maintain the ER at metastatic sites. Despite anti-estrogen therapy, almost 30% of ER+ BC patients relapse. Thus, new therapeutic targets for ER+ BC are needed.
Gabriela Vazquez Rodriguez, Gabriela Vazquez Rodriguez, Annelie Abrahamsson, Annelie Abrahamsson, Maria V. Turkina, Charlotta Dabrosin, Charlotta Dabrosin   +6 more
doaj   +1 more source

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

The dual incretin agonist tirzepatide blunts nicotine‐induced behaviours and neurochemistry in male mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Nicotine dependence remains one of the leading causes of morbidity and mortality worldwide, with high relapse rates and post‐cessation weight gain representing persistent barriers to sustained abstinence. The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) have ...
Christian E. Edvardsson, Thaynnam A. Emous, Sarah Witley, Mia Ericson, Louise Adermark, Elisabet Jerlhag   +5 more
wiley   +1 more source

Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents

British Journal of Pharmacology, EarlyView.
Background and Purpose Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...
Patrik Meglić, Petra Šoštarić, Eirini Tsape, Melpomeni Galani, Ana Knezović, Laura Restani, Marco Pirazzini, Ornella Rossetto, Gareth B. Miles, Laskaro Zagoraiou, Ivica Matak   +10 more
wiley   +1 more source

The configuration of the microdialysis system.

, 2019
The configuration of the microdialysis system.
Xiukun Wang (6807905), Qing Wang (27728), Jing Pang (844287), Xin-Yi Yang (6396242), Xin-Xin Hu (4855966), Cong-Ran Li (6807902), Tong-Ying Nie (4855963), Jian-Dong Jiang (346645), Xue-Fu You (4855969), Rui Zhao (43391), Xi Lu (288663)   +10 more
core   +1 more source

Microdialysis-Assessed Adipose Tissue Metabolism, Circulating Cytokines and Outcome in Critical Illness

Metabolites, 2018
Microdialysis (MD) can provide continuous information about tissue composition. To assess in critically ill patients adipose tissue metabolic patterns, the relationships between metabolic patterns and blood cytokine concentration associations of adipose ...
Ioannis Ilias, Sofia Apollonatou, Nikitas Nikitas, Maria Theodorakopoulou, Alice G Vassiliou, Anastasia Kotanidou, Ioanna Dimopoulou   +6 more
doaj   +1 more source

Plasma EC90 multiples are drug, target site and species specific—A physiologically based pharmacokinetic modelling example of nirmatrelvir central nervous system distribution

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Achieving minimum unbound drug concentration in plasma above in vitro EC90 is a common antiviral pharmacokinetic/pharmacodynamic (PK/PD) target. However, it often overlooks restricted distribution into target sites like the central nervous system (CNS), where a trough concentration above 1 × EC90 is needed.
Daan W. van Valkengoed, Xuanlin Liu, Sean N. Avedissian, Courtney V. Fletcher, Ashley N. Brown, Elizabeth C. M. de Lange, Anne‐Grete Märtson   +6 more
wiley   +1 more source

Administration parameters used for brain microdialysis experiments.

, 2013
Administration parameters used for brain microdialysis experiments.
Erica Szorath (492207), Anaëlle Fabulas - da Costa (492205), Yan Hongmei (492210), Mila Renftel (492209), Emmanuel Sevin (492206), Romeo Cecchelli (5656909), Stefan Lundquist (492211), Maxime Culot (492204), Stefan Martinsson (492208)   +8 more
core   +1 more source

The Effect of Being Aerobically Active vs. Inactive on Cutaneous Vascular Conductance during Local Heat Stress in an Older Population

Frontiers in Physiology, 2017
Objective: To test the hypothesis that long- term aerobically trained elderly individuals have a greater amount of bioavailable nitric oxide (NO) and have a larger cutaneous vasodilation during local heat stress compared to their inactive elderly ...
Ulrike H. Mitchell, Samantha Burton, Christopher Gordon, Gary W. Mack   +3 more
doaj   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source