Results 81 to 90 of about 34,690 (216)

Applicability of reverse microdialysis in pharmacological and toxicological studies [PDF]

, 2007
A recent application of microdialysis is the introduction of a substance into the extracellular space via the microdialysis probe. The inclusion of a higher amount of a drug in the perfusate allows the drug to diffuse through the microdialysis membrane ...
Opezzo, Javier A. W., Taira, Carlos Alberto, Höcht, Christian   +2 more
core   +1 more source

In-vitro gadolinium retro-microdialysis in agarose gel—a human brain phantom study

Frontiers in Radiology
Rationale and objectivesCerebral microdialysis is a technique that enables monitoring of the neurochemistry of patients with significant acquired brain injury, such as traumatic brain injury (TBI) and subarachnoid haemorrhage (SAH).
Chisomo Zimphango, Marius O. Mada, Marius O. Mada, Stephen J. Sawiak, Stephen J. Sawiak, Susan Giorgi-Coll, T. Adrian Carpenter, Peter J. Hutchinson, Peter J. Hutchinson, Keri L. H. Carpenter, Keri L. H. Carpenter, Matthew G. Stovell, Matthew G. Stovell   +12 more
doaj   +1 more source

In vitro microdialysis membrane efficiency of broad-spectrum antibiotics in combination and alone

, 2014
Shawn H MacVane,1 Seth T Housman,1 David P Nicolau1,21Center for Anti-Infective Research and Development, 2Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USAPurpose: Microdialysis is a valuable technique for studying the distribution ...
Nicolau DP, MacVane SH, Housman ST
core  

Oral Cannabidiol Prevents Allodynia and Neurological Dysfunctions in a Mouse Model of Mild Traumatic Brain Injury

Frontiers in Pharmacology, 2019
Neurological dysfunctions are the most impactful and persistent consequences of traumatic brain injury (TBI). Indeed, previous reports suggest that an association between TBI and chronic pain syndromes, as well anxio-depressive behaviors, tends to be ...
Carmela Belardo, Monica Iannotta, Serena Boccella, Rosamaria Cristina Rubino, Flavia Ricciardi, Rosmara Infantino, Gorizio Pieretti, Luigi Stella, Salvatore Paino, Ida Marabese, Rosa Maisto, Livio Luongo, Sabatino Maione, Francesca Guida   +13 more
doaj   +1 more source

Applicability of free drug hypothesis to drugs with good membrane permeability that are not efflux transporter substrates: A microdialysis study in rats

Pharmacology Research & Perspectives, 2020
In clinical pharmacology, the free drug hypothesis has been widely applied in the interpretation of the relationship between pharmacokinetics and pharmacodynamics (PK/PD).
Chun Chen, Hongyu Zhou, Chi Guan, Huanhuan Zhang, Yingying Li, Xue Jiang, Zheng Dong, Yuanyuan Tao, Juan Du, Shuyao Wang, Teng Zhang, Na Du, Junyang Guo, Yaqiong Wu, Zehai Song, Haofei Luan, Yu Wang, Hongwen Du, Shaofeng Zhang, Chen Li, Hang Chang, Tao Wang   +21 more
doaj   +1 more source

Low‐threshold cutaneous mechanoreceptors on the foot sole have enhanced sensitivity when skin temperature is elevated

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of microneurography recordings used to examine the effects of local skin heating on cutaneous mechanoreceptor responses in the human foot (left panel). A microelectrode inserted into a peripheral nerve records single‐unit activity from tactile afferent fibres while controlled mechanical stimuli are applied ...
Erika E. Howe, Michael Apollinaro, Joanna Reeves, Christopher Nester, Leah R. Bent   +4 more
wiley   +1 more source

S1 Table. Microdialysis data

, 2015
Data set containing microdialysis values for dopamine (DA) and serotonin (5HT) in the medial (DMS) and lateral (DLS) dorsal striatum of exercising and sedentary rats.
Peter Clark (775670)
core   +1 more source

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones

The Journal of Physiology, EarlyView.
Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu, Eduardo Bravo, George Bradley Richerson   +2 more
wiley   +1 more source

Microdialysis of large molecules [PDF]

The AAPS Journal, 2005
Microdialysis has been used in many tissues, including skin, brain, adipose tissue, muscle, kidney, and gastrointestinal tract, to recover low-molecular mass endogenous mediators, metabolites, and xenobiotics from the interstitial space. Recently, molecules of larger molecular mass, such as plasma proteins, cytokines, growth factors, and neuropeptides,
openaire   +3 more sources

KV channels contribute to thermal hyperaemia in skeletal muscle of humans

The Journal of Physiology, EarlyView.
Abstract figure legend Using skeletal muscle microdialysis and pulsed short‐wave diathermy, we examined the contribution of KV channels to thermal hyperaemia in human skeletal muscle. KV channel antagonism with 4‐aminopyridine attenuated thermal hyperaemia by ∼65%, identifying a critical downstream role for these ion channels in the vasodilatory ...
Ysabella I. Ruiz‐Pick, Sophia G. Wagle‐Babb, Asim Kichloo, Albert H. Olivencia‐Yurvati, Gregory M. Dick, Steven A. Romero   +5 more
wiley   +1 more source