Results 71 to 80 of about 58,170 (269)

Lysine in Combination With Estradiol Promote Dissemination of Estrogen Receptor Positive Breast Cancer via Upregulation of U2AF1 and RPN2 Proteins

Frontiers in Oncology, 2020
The majority of estrogen receptor positive (ER+) breast cancer (BC) maintain the ER at metastatic sites. Despite anti-estrogen therapy, almost 30% of ER+ BC patients relapse. Thus, new therapeutic targets for ER+ BC are needed.
Gabriela Vazquez Rodriguez, Gabriela Vazquez Rodriguez, Annelie Abrahamsson, Annelie Abrahamsson, Maria V. Turkina, Charlotta Dabrosin, Charlotta Dabrosin   +6 more
doaj   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome-c-Oxidase in Traumatic Brain Injury Patients during Hypercapnoea A Broadband NIRS Study [PDF]

, 2011
Using broadband near-infrared spectroscopy (NIRS) and cerebral micro-dialysis (MD), we investigated cerebral cellular metabolism and mitochondrial redox states, following hypercapnoea in 6 patients with traumatic brain injury (TBI).
Elwell, CE, Ghosh, A, Leung, TS, Pritchard, C, Smith, M, Tachtsidis, I, Tisdall, MM   +6 more
core   +1 more source

The effect of repeated hot water immersion on microvascular function, glycaemic control and inflammation in White European and South Asian males

Experimental Physiology, EarlyView.
Abstract Individuals of South Asian (SA) descent display a higher risk for cardiovascular disease and type 2 diabetes mellitus than their White European (WE) counterparts. Heat therapy, such as hot water immersion (HWI), can improve microvascular function and glycaemic control, although effects across racial groups are unknown.
David Bellini, Alex Lloyd, Christof A. Leicht, Stephen J. Bailey, Lewis J. James, Matthew J. Maley   +5 more
wiley   +1 more source

Clinical value of bioelectrical properties of cancerous tissue in advanced epithelial ovarian cancer patients [PDF]

, 2018
Currently, there are no valid pre-operatively established biomarkers or algorithms that can accurately predict surgical and clinical outcome for patients with advanced epithelial ovarian cancer (EOC).
Boutelle, Martyn G., Cunnea, Paula, Curry, Ed, Domenici, Lavinia, Drakakis, Emmanuel M., Fotopoulou, Christina, Gabra, Hani, Gorgy, Tommy, Gowers, Sally A. N., Lawton, Phillip, Leng Leong, Chi, Lu, Haonan, Morera, Cristina, Nixon, Katherine, Paterson, Andrew, Petkos, Konstantinos, Sorbi, Flavia, Wu, Wen   +17 more
core   +2 more sources

Microdialysis-Assessed Adipose Tissue Metabolism, Circulating Cytokines and Outcome in Critical Illness

Metabolites, 2018
Microdialysis (MD) can provide continuous information about tissue composition. To assess in critically ill patients adipose tissue metabolic patterns, the relationships between metabolic patterns and blood cytokine concentration associations of adipose ...
Ioannis Ilias, Sofia Apollonatou, Nikitas Nikitas, Maria Theodorakopoulou, Alice G Vassiliou, Anastasia Kotanidou, Ioanna Dimopoulou   +6 more
doaj   +1 more source

Quantifying microvascular responses to local heating using optical coherence tomography: Comparison between skin sites and sex differences

Experimental Physiology, EarlyView.
Summary of the study design, metholodgy, results and conclusions. Abstract Due to a lack of technical capacity to directly visualise and quantify microvessels in the skin, little is known regarding regional and/or sex differences. We compared diameter, velocity, flow and density at four regional sites using a novel optical coherence tomography (OCT ...
Juliene G. Costa, Kristanti W. Wigati, Louise H. Naylor, Helen Jones, Robert A. McLaughlin, Daniel J. Green   +5 more
wiley   +1 more source

COX inhibition: Catalepsy and Striatum Dopaminergic-GABAergic-Glutamatergic Neurotransmission [PDF]

, 2008
Selective COX-2 and COX-1 inhibitors were administered (i.p. acutely) to normal and parkinsonian rats, followed by the analysis of the striatal dopamine, GABA and glutamate concentrations using the microdialysis technique, simultaneously, the catalepsy ...
Abbas Shafiee, Amin Gravand, Davood Barzegar-Pourshuraki, Hadi Fathi-Moghaddam, Hojat Ebrahiminik, Latifeh Navidpour, Mehdi Shafiee Ardestani, Meysam Shafiee Ardestani   +7 more
core   +1 more source

Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents : an in vitro study [PDF]

, 2013
Adenosine acting in the basal forebrain is a key mediator of sleep homeostasis. Extracellular adenosine concentrations increase during wakefulness, especially during prolonged wakefulness and lead to increased sleep pressure and subsequent rebound sleep.
A Alonso, A Khateb, A Serrano, AV Kalinchuk, AV Kalinchuk, AV Kalinchuk, BB Fredholm, BG Frenguelli, BP Klyuch, BP Klyuch, C Romano, C Xu, CF Hohmann, D Curran-Everett, D Lovatt, D Stenberg, DG Van Wylen, E Llaudet, E Murillo-Rodriguez, EA Newman, F Longordo, H McIlwain, HK Wigren, Houdini Ho Tin Wu, I Haulica, ID Manns, J Grivel, JB Mitchell, JC Hoffmann, JP Mothet, JT McKenna, JT Porter, LA Etherington, LI Kiyashchenko, LI Schmitt, LO Alanko, M Ballarin, M Radulovacki, M van den Top, M Wall, MA Greco, MG Lee, MJ Wall, MM Halassa, MM Halassa, MM Thakkar, MO Enkvist, Nicholas Dale, O Pascual, P Franken, P Maquet, R Basheer, R Basheer, R Basheer, R Shigemoto, RH Farkas, RM Virus, Robert Edward Sims, S Palchykova, SR Glaum, SR Ticho, T Porkka-Heiskanen, T Porkka-Heiskanen, T Porkka-Heiskanen, TE Bjorness, TR Minor, TV Dunwiddie, V Parpura, V Ramesh, Valérie Mongrain, VM Sciotti, WE Cullinan, ZL Huang   +72 more
core   +2 more sources