Results 71 to 80 of about 34,690 (216)

Pathological Ossification of Spinal Ligament‐Derived Fibroblasts in an Inflammatory Micro‐Environment via Activation of the ECM/ITGA5/FAK/AKT Pathway in Ankylosing Spondylitis

Cell Proliferation, EarlyView.
Schematic diagram illustrating the activation of the ECM/ITGA5/FAK/AKT axial signalling pathway in the osteogenic transdifferentiation of AS ligaments‐derived fibroblasts and the simulation of ectopic ossification via subcutaneous transplantation in vivo.
Mu Qiao, Kai‐Yang Wang, Chen‐Yu Song, Jing‐Shun Lu, Jiu‐Kun Li, Yong Qiu, Bang‐Ping Qian, Ze‐Zhang Zhu   +7 more
wiley   +1 more source

An Approach to Collect Non-Standard Microdialysis Compounds [PDF]

, 2016
Microdialysis is a sampling technique that is used to collect analytes through a semipermeable membrane. The collection occurs via the microdialysis probe where analytes can diffuse through the membrane and be collected by use of the outlet ...
Schneider, Allison M
core   +3 more sources

Pharmacological and Behavioral Effects of the Synthetic Cannabinoid AKB48 in Rats

Frontiers in Neuroscience, 2019
AKB48 is a designer drug belonging to the indazole synthetic cannabinoids class, illegally sold as herbal blend, incense, or research chemicals for their psychoactive cannabis-like effects.
Sabrine Bilel, Micaela Tirri, Raffaella Arfè, Raffaella Arfè, Serena Stopponi, Laura Soverchia, Roberto Ciccocioppo, Paolo Frisoni, Sabina Strano-Rossi, Cristina Miliano, Fabio De-Giorgio, Giovanni Serpelloni, Anna Fantinati, Maria Antonietta De Luca, Margherita Neri, Matteo Marti, Matteo Marti   +16 more
doaj   +1 more source

Distribution and target engagement of peripherally administered fremanezumab in the cerebrospinal fluid of healthy volunteers

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Our objective was to describe the distribution of fremanezumab to the cerebrospinal fluid (CSF) in healthy volunteers, and investigate its engagement and stabilization of its target, calcitonin gene‐related peptide (CGRP). Fremanezumab is a CGRP‐targeting monoclonal antibody approved for migraine prevention.
Jacki Rorabaugh, Edward Hellriegel, Juline Bryson, Ryan Tiver, Hang Zeng, Xiaofeng Lu, Steve Barash, Giulia Ghibellini, Olga Szilagyi, Ignacio Echenique, Andrew H. Ahn, Peter J. Goadsby, Laura Rabinovich‐Guilatt   +12 more
wiley   +1 more source

The effect of repeated hot water immersion on microvascular function, glycaemic control and inflammation in White European and South Asian males

Experimental Physiology, EarlyView.
Abstract Individuals of South Asian (SA) descent display a higher risk for cardiovascular disease and type 2 diabetes mellitus than their White European (WE) counterparts. Heat therapy, such as hot water immersion (HWI), can improve microvascular function and glycaemic control, although effects across racial groups are unknown.
David Bellini, Alex Lloyd, Christof A. Leicht, Stephen J. Bailey, Lewis J. James, Matthew J. Maley   +5 more
wiley   +1 more source

A Review of Neurotransmitters Sensing Methods for Neuro-Engineering Research

Applied Sciences, 2019
Neurotransmitters as electrochemical signaling molecules are essential for proper brain function and their dysfunction is involved in several mental disorders.
Shimwe Dominique Niyonambaza, Praveen Kumar, Paul Xing, Jessy Mathault, Paul De Koninck, Elodie Boisselier, Mounir Boukadoum, Amine Miled   +7 more
doaj   +1 more source

Quantifying microvascular responses to local heating using optical coherence tomography: Comparison between skin sites and sex differences

Experimental Physiology, EarlyView.
Summary of the study design, metholodgy, results and conclusions. Abstract Due to a lack of technical capacity to directly visualise and quantify microvessels in the skin, little is known regarding regional and/or sex differences. We compared diameter, velocity, flow and density at four regional sites using a novel optical coherence tomography (OCT ...
Juliene G. Costa, Kristanti W. Wigati, Louise H. Naylor, Helen Jones, Robert A. McLaughlin, Daniel J. Green   +5 more
wiley   +1 more source

Neurocritical care monitoring

Journal of Pediatric Critical Care, 2015
Neurocritical care in children is aimed at the prevention and treatment of secondary brain injury. Advanced neuromonitoring tools have gained popularity over the last decade owing to its ability to gather and integrate information related to ...
Ankit Mehta, Karthi Nallasamy
doaj   +1 more source

Quantifying skin microvascular function responses to distinct forms of heat stress in humans using optical coherence tomography

Experimental Physiology, EarlyView.
Abstract Optical coherence tomography (OCT) enables visualization and quantification of the cutaneous microvasculature, yet no study has compared responses to distinct forms of heating in humans. We hypothesized that local skin heating (LH) would evoke larger responses in microvascular diameter, velocity, flow and density than passive whole‐body ...
Kristanti W. Wigati, Robert A. McLaughlin, Harrison T. Caddy, Howard H. Carter, Louise H. Naylor, Daniel J. Green   +5 more
wiley   +1 more source

Determination and Pharmacokinetic Profile of Omeprazole in Rat Blood, Brain and Bile by Microdialysis and High-Performance Liquid Chromatography

, 2009
The disposition and biliary excretion of omeprazole was investigated following i.v. administration to rats at 10 mg/ kg. We used a microdialysis technique coupled to a validated microbore HPLC system to monitor the levels of protein- unbound omeprazole ...
HO, YUNN-FANG;CHEN, CHIEH-FU, 何藴芳;陳介甫   +1 more
core