Results 91 to 100 of about 34,690 (216)

A Microdialysis in Adjuvant Arthritic Rats for Pharmacokinetics–Pharmacodynamics Modeling Study of Geniposide with Determination of Drug Concentration and Efficacy Levels in Dialysate

Molecules, 2018
Microdialysis, a sampling method for pharmacokinetics–pharmacodynamics (PK–PD) modeling in preclinical and clinical studies, is a convenient in vivo sampling technique.
Ran Deng, Wei Wang, Hong Wu, Yunjing Zhang, Wenyu Wang, Li Dai, Zhengrong Zhang, Jun Fu, Feng Li   +8 more
doaj   +1 more source

Real‐Time Neurochemical Sensing in Zebrafish: Electrochemical and Fluorescent Approaches

Analysis &Sensing, Volume 6, Issue 6, November 2026.
The use of zebrafish has emerged as a powerful approach for real‐time neurochemical measurements. This review highlights recent advances in electrochemical and fluorescent sensing strategies that enable dynamic measurements in live preparations of this complex vertebrate. These complementary approaches provide new insights into neurochemical signaling,
Piyanka Hettiarachchi, Jacob T. Theismann, Michael A. Johnson   +2 more
wiley   +1 more source

Advanced monitoring in traumatic brain injury: microdialysis [PDF]

, 2017
Purpose of review: Here, we review the present state-of-the-art of microdialysis for monitoring patients with severe traumatic brain injury, highlighting the newest developments.

core   +2 more sources

Improved Serotonin Measurement With Fast‐Scan Cyclic Voltammetry: Analysis of Electrode Fouling by Fluoxetine in Live Brain Tissue

Analysis &Sensing, Volume 6, Issue 6, November 2026.
Fluoxetine (Prozac) is a drug that is useful for treating depression and for studying serotonin system function in live brain tissue. Unfortunately, the use of fluoxetine tends to foul electrodes when using fast‐scan cyclic voltammetry. In this work, we evaluated an extended serotonin waveform as a useful approach for mitigating fouling by fluoxetine ...
Chase Stucky, Delaney Lounce, Kailash Shrestha, Jing Tian, Ethan Gomez, Heng Du, Kandace Fleming, Michael A. Johnson   +7 more
wiley   +1 more source

Monitoring Microdialysis

, 2020
Microdialysis is a monitoring tool providing early warning regarding upcoming ischemia, mitochondrial dysfunction and cell death. Interpreting the results and deciding where to place the catheter are in itself a challenge when the monitoring method isn’t
Nordström, Carl-Henrik, Reinstrup, Peter, Peter Reinstrup, Carl-Henrik Nordström   +3 more
core   +1 more source

Age-Dependent Changes in Taurine, Serine, and Methionine Release in the Frontal Cortex of Awake Freely-Moving Rats: A Microdialysis Study

Life
Brain function declines because of aging and several metabolites change their concentration. However, this decrease may be a consequence or a driver of aging.
Cristina Cueto-Ureña, María Jesús Ramírez-Expósito, María Pilar Carrera-González, José Manuel Martínez-Martos   +3 more
doaj   +1 more source

Brain Microdialysate Monoamines in Relation to Circadian Rhythms, Sleep, and Sleep Deprivation – a Systematic Review, Network Meta-analysis, and New Primary Data

Journal of Circadian Rhythms, 2019
Disruption of the monoaminergic system, e.g. by sleep deprivation (SD), seems to promote certain diseases. Assessment of monoamine levels over the circadian cycle, during different sleep stages and during SD is instrumental to understand the molecular ...
Julia M. L. Menon, Christ Nolten, E. J. Marijke Achterberg, Ruud N. J. M. A. Joosten, Maurice Dematteis, Matthijs G. P. Feenstra, W. H. (Pim) Drinkenburg, Cathalijn H. C. Leenaars   +7 more
doaj   +1 more source

The lipid-mobilizing effect of atrial natriuretic peptide is unrelated to sympathetic nervous system activation or obesity in young men

Journal of Lipid Research, 2001
We recently demonstrated that natriuretic peptides and especially the atrial natriuretic peptide (ANP) are powerful lipolytic agents on isolated human fat cells.
Jean Galitzky, Coralie Sengenès, Claire Thalamas, Marie Adeline Marques, Jean-Michel Senard, Max Lafontan, Michel Berlan   +6 more
doaj   +1 more source

Enhanced microdialysis of neuropeptides. [PDF]

, 2001
An enhanced microdialysis method for neuropeptides is described and some preliminary results of this novel approach are presented. The enhancement is achieved by adding a vehicle (solid support) to the perfusion fluid in order to increase the diffusion ...
Markides, Karin, Bergquist, Jonas, Pettersson, Andreas   +2 more
core  

Microdialysis-assessed adipose tissue metabolism in critically ill patients

, 2017
Background: Microdialysis is a minimally invasive technique that allows direct in situ and in vivo sampling, studies and manipulations of the interstitial/extracellular fluid/space.
Ilias, I., Theodorakopoulou, M., Nikitas, N., Dimopoulou, I.   +3 more
core   +1 more source