Microfilament‐Myosin II Regulates the Differentiation of Multinucleated Cysts into Oocytes and Influences Oocyte Developmental Potential in Mice [PDF]
Advanced SciencePrimary oocyte differentiation in females is a complex and selective process; however, its regulatory mechanisms remain poorly understood. In this study, multinucleated cysts are identified as precursors for oocyte differentiation.
Rui Xu +7 more
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Extracellular AMP Inhibits Pollen Tube Growth in Picea meyeri via Disrupted Calcium Gradient and Disorganized Microfilaments [PDF]
PlantsAdenosine monophosphate (AMP) is a hydrolysis product of adenosine triphosphate (ATP) and adenosine diphosphate (ADP). In mammalian cells, extracellular AMP functions as a signaling molecule by binding to adenosine A1 receptors, thereby activating ...
Junhui Zhou +4 more
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Mechanical Sensing Element PDLIM5 Promotes Osteogenesis of Human Fibroblasts by Affecting the Activity of Microfilaments [PDF]
Biomolecules, 2021 Human skin fibroblasts (HSFs) approximate the multidirectional differentiation potential of mesenchymal stem cells, so they are often used in differentiation, cell cultures, and injury repair. They are an important seed source in the field of bone tissue
Xiaolan Huang +12 more
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Polycystin‐1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1‐Dependent Microfilament Remodeling [PDF]
Advanced ScienceExtracellular matrix (ECM) stiffness‐mediated mechanotransduction is a common signaling scheme in both physiological and pathological contexts; however, its molecular mechanisms remain incompletely understood. Polycystin‐1 is a transmembrane protein that
Jiaofeng Zhou +12 more
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PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects [PDF]
Advanced ScienceNeural tube defects (NTDs) are complex multigenic disorders and are the most prevalent and severe congenital malformations that affect the central nervous system.
Xiaoshuai Li +6 more
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International Journal of General MedicineJunbo Hong,1 Qingzi Fu,2 Liang Zhu,1 Zhenzhen Yang,1 Jianhua Wan,1 Qiaofeng Chen,1 Peng Chen,1 Shiyu Zhang1 1Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology ...
Hong J +7 more
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Research progress on the roles of actin-depolymerizing factor in plant stress responses
Frontiers in Plant Science, 2023 Actin-depolymerizing factors (ADFs) are highly conserved small-molecule actin-binding proteins found throughout eukaryotic cells. In land plants, ADFs form a small gene family that displays functional redundancy despite variations among its individual ...
Yongwang Sun +8 more
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Actin microfilament mediates osteoblast Cbfa1 responsiveness to BMP2 under simulated microgravity. [PDF]
PLoS ONE, 2013 Microgravity decreases osteoblastic activity, induces actin microfilament disruption and inhibits the responsiveness of osteoblast to cytokines, but the mechanisms remains enigmatic.
Zhongquan Dai +10 more
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Organization of the Cytoskeleton in Ectopic Foci of the Endometrium with Rare Localization
Biomedicines, 2021 (1) Background: Endometriosis is a common pathology of the female reproductive system, often accompanied by pain and decreased fertility. However, its pathogenesis has not been sufficiently studied regarding the role of the cytoskeleton.
Konstantin A. Toniyan +4 more
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Frontiers in Medicine, 2021 Laterality defects (LDs) or asymmetrically positioned organs are a group of rare developmental disorders caused by environmental and/or genetic factors. However, the exact molecular pathophysiology of LD is not yet fully characterised.
Rabab Said Alsafwani +21 more
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