The Significant Role of the Microfilament System in Tumors [PDF]
Frontiers in Oncology, 2021 Actin is the structural protein of microfilaments, and it usually exists in two forms: monomer and polymer. Among them, monomer actin is a spherical molecule composed of a polypeptide chain, also known as spherical actin.
Yanhong Zhou
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Actin Microfilament Mediates Osteoblast Cbfa1 Responsiveness to BMP2 under Simulated Microgravity [PDF]
PLoS ONE, 2013 Microgravity decreases osteoblastic activity, induces actin microfilament disruption and inhibits the responsiveness of osteoblast to cytokines, but the mechanisms remains enigmatic.
Zhongquan Dai
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Research progress on the roles of actin-depolymerizing factor in plant stress responses [PDF]
Frontiers in Plant Science, 2023 Actin-depolymerizing factors (ADFs) are highly conserved small-molecule actin-binding proteins found throughout eukaryotic cells. In land plants, ADFs form a small gene family that displays functional redundancy despite variations among its individual ...
Yongwang Sun +8 more
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Frontiers in Pharmacology, 2020 Microcystin-leucine arginine (MC-LR) is a potent tumor initiator that can induce malignant cell transformation. Cellular mechanical characteristics are pivotal parameters that are closely related to cell invasion.
Guihua Wang, Fuqiang Tian, Guohui Wang
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Extracellular AMP Inhibits Pollen Tube Growth in Picea meyeri via Disrupted Calcium Gradient and Disorganized Microfilaments [PDF]
PlantsAdenosine monophosphate (AMP) is a hydrolysis product of adenosine triphosphate (ATP) and adenosine diphosphate (ADP). In mammalian cells, extracellular AMP functions as a signaling molecule by binding to adenosine A1 receptors, thereby activating ...
Junhui Zhou +4 more
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Villin: The major microfilament-associated protein of the intestinal microvillus
Proceedings of the National Academy of Sciences of the United States of America, 1979 The major protein associated with actin in the microfilament core of intestinal microvilli has been purified. This protein, for which we propose the name villin, has a polypeptide molecular weight of approximately 95,000.
Anthony Bretscher, Klaus Weber
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Hierarchical multiscale model for biomechanics analysis of microfilament networks
Journal of Applied Physics, 2013 The mechanisms of force generation and transference via microfilament networks are crucial to the understandings of mechanobiology of cellular processes in living cells.
Prasad K D V Yarlagadda +2 more
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Genome-wide characterization and expression analysis of the ADF gene family in response to salt and drought stress in alfalfa (Medicago sativa) [PDF]
Frontiers in Plant ScienceThe microfilament cytoskeleton, formed by the process of actin polymerization, serves not only to support the morphology of the cell, but also to regulate a number of cellular activities.
Mengmeng Shi +12 more
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Regulation of the integrin αVβ3- actin filaments axis in early osteogenic differentiation of human mesenchymal stem cells under cyclic tensile stress [PDF]
Cell Communication and Signaling, 2023 Background Integrins are closely related to mechanical conduction and play a crucial role in the osteogenesis of human mesenchymal stem cells. Here we wondered whether tensile stress could influence cell differentiation through integrin αVβ3.
Yan Peng +12 more
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Biomolecules, 2021 Human skin fibroblasts (HSFs) approximate the multidirectional differentiation potential of mesenchymal stem cells, so they are often used in differentiation, cell cultures, and injury repair. They are an important seed source in the field of bone tissue
Xiaolan Huang +12 more
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