Results 101 to 110 of about 25,438 (250)

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source

The light chain 1 subunit of the microtubule-associated protein 1B (MAP1B) is responsible for Tiam1 binding and Rac1 activation in neuronal cells.

PLoS ONE, 2012
Microtubule-associated protein 1B (MAP1B) is a neuronal protein involved in the stabilization of microtubules both in the axon and somatodendritic compartments.
Daniel R Henríquez, Felipe J Bodaleo, Carolina Montenegro-Venegas, Christian González-Billault   +3 more
doaj   +1 more source

Multifunctional antimicrobial peptide‐containing electrospun nanofibrous dressings for accelerating wound healing with exposed bone

VIEW, EarlyView.
(a) Schematic representation of the chemical cross‐linking of PVB/PCL‐TiO2‐RegIIIγ electrospun nanofibers. (b) Schematic illustration of the biomimetic dressing promoting healing in an exposed bone wound. The treatment of wounds with exposed bone has always been a difficult problem in the clinical treatment of orthopedics.
Chenhao Gong, Xuewei Fu, Peng Wang, Hui Zhao, Cheng Wang, Wuyi Zhou, Yuanjun Xia   +6 more
wiley   +1 more source

Hsp27 anti-sense oligonucleotides sensitize the microtubular cytoskeleton of Chinese hamster ovary cells grown at low pH to 42 degrees C-induced reorganization [PDF]

, 2004
Chinese hamster ovary (CHO) cells maintained in vitro at pH 6.7 were used to model cells in the acidic environment of tumours. CHO cells grown at pH 6.7 develop thermotolerance during 42 degrees C heating at pH 6.7 and their cytoskeletal systems are ...
Coss, Ronald A., Hargis, Michael T., Leeper, Dennis B., Storck, C. W., Wickstrom, Eric, Yakubov, Leonid A.   +5 more
core   +1 more source

Identification of two mutation sites in spike and envelope proteins mediating optimal cellular infection of porcine epidemic diarrhea virus from different pathways

Veterinary Research, 2017
Entry of the α-coronavirus porcine epidemic diarrhea virus (PEDV) requires specific proteases to activate spike (S) protein for the membrane fusion of the virion to the host cell following receptor binding. Herein, PEDV isolate 85-7 could proliferate and
Min Sun, Jiale Ma, Zeyanqiu Yu, Zihao Pan, Chengping Lu, Huochun Yao   +5 more
doaj   +1 more source

Expanding the Genotype and Phenotype Diversity in a Chinese Cohort With TRPV4‐Related Dysplasia

Clinical Genetics, EarlyView.
Exploring the genotype and phenotype diversity in a Chinese cohort with TRPV4‐related dysplasia. ABSTRACT Dominant mutations in the calcium permeable ion channel TRPV4 (transient receptor potential vanilloid 4) typically result in skeletal dysplasia or peripheral neuromuscular disease.
Lina Dong, Kwan Chun Ho, Zhijia Tan, Yanni He, Yapeng Zhou, Shijie Yin, Lin Feng, Janus Siu Him Wong, Michael Kai Tsun To   +8 more
wiley   +1 more source

Modulation of the extracellular matrix patterning of thrombospondins by actin dynamics and thrombospondin oligomer state [PDF]

, 2015
Thrombospondins (TSPs) are evolutionarily-conserved, secreted glycoproteins that interact with cell surfaces and extracellular matrix (ECM) and have complex roles in cell interactions.
Adams, Josephine C, Christofidou, Elena, Gong, Xianyun, Hellewell, Andrew L, Schärich, Karsten   +4 more
core   +3 more sources

Desmosomal Molecules In and Out of Adhering Junctions: Normal and Diseased States of Epidermal, Cardiac and Mesenchymally Derived Cells

Dermatology Research and Practice, 2010
Current cell biology textbooks mention only two kinds of cell-to-cell adhering junctions coated with the cytoplasmic plaques: the desmosomes (maculae adhaerentes), anchoring intermediate-sized filaments (IFs), and the actin microfilament-anchoring ...
Sebastian Pieperhoff, Mareike Barth, Steffen Rickelt, Werner W. Franke   +3 more
doaj   +1 more source

Tetratricopeptide repeat domain 9A is an interacting protein for tropomyosin Tm5NM-1

BMC Cancer, 2008
Background Tetratricopeptide repeat domain 9A (TTC9A) protein is a recently identified protein which contains three tetratricopeptide repeats (TPRs) on its C-terminus.
Ho Gay, Cao Shenglan, Lin Valerie CL
doaj   +1 more source

Neurotrophic extracellular matrix proteins promote neuronal and iPSC astrocyte progenitor cell‐ and nano‐scale process extension for neural repair applications

Journal of Anatomy, Volume 246, Issue 4, Page 585-601, April 2025.
The extracellular matrix plays a critical role in modulating cell behaviour in the central nervous system influencing neural cell morphology and growth. However, a better understanding of the impact of individual matrix proteins on both neurons and astrocytes is critical for advancing the development of matrix‐based neural repair strategies.
Cian O'Connor, Rena E. Mullally, Sarah F. McComish, Julia O'Sullivan, Ian Woods, Ingmar Schoen, Massimiliano Garre, Maeve A. Caldwell, Adrian Dervan, Fergal J. O'Brien   +9 more
wiley   +1 more source