Results 121 to 130 of about 116,651 (165)

Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition

Chemistry &Biodiversity, EarlyView.
ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi, Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Ali K. Albuhadily, Morkoss M. Fakhry, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +7 more
wiley   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Bioactives From Brown Algae: Antioxidant, Anti‐Inflammatory, Anticancer, and Antimicrobial Potential

ChemBioEng Reviews, EarlyView.
This review explores key bioactives in brown algae and their antioxidant, anti‐inflammatory, anticancer, and antimicrobial properties. Covering studies from 2014 to 2024, it highlights their relevance in pharmaceuticals, nutraceuticals, cosmetics, and foods, while addressing challenges and future directions to unlock their full potential.
Irvin Fonseca‐Barahona, Kaveh Shahbaz, Saeid Baroutian   +2 more
wiley   +1 more source

PCFT‐Independent Cellular Uptake of Cyclic Cell‐Penetrating Peptide‐Conjugated Folic Acid

ChemBioChem, EarlyView.
Cell‐penetrating peptide (CPP)‐conjugated folic acid mediates efficient internalization of folic acid that is independent of the presence of proton‐coupled folate transporter (PCFT) on the intestinal cells. CPP‐conjugated folic acid demonstrates superior cellular uptake at all studied pH and in the presence of PCFT inhibitors and shows enhanced ...
Vineet Kumar Mishra, Rheal Towner, Juan Carlos Rodriguez‐Lecompte, Marya Ahmed   +3 more
wiley   +1 more source

Translational Medicine in Alzheimer's Disease: The Journey of Donanemab From Discovery to Clinical Application

Chronic Diseases and Translational Medicine, EarlyView.
Donanemab, approved by the U.S. FDA in July 2024, targets amyloid plaques in the brain to treat Alzheimer's disease in patients with mild cognitive impairment or mild dementia. ABSTRACT Substantial research has been conducted to identify an efficient treatment for Alzheimer's disease (AD).
Nandhini Jayaprakash, Karthikeyan Elumalai   +1 more
wiley   +1 more source

Amyloid‐Related Imaging Abnormality (ARIA) Beyond the APOE‐ε4 Allele

Chronic Diseases and Translational Medicine, EarlyView.
Mechanism of action of monoclonal antibodies targeting Aβ in the treatment of AD. (A) Targets of various mAbs. (B) Mechanism of monoclonal antibody‐mediated clearance of Aβ. mAbs facilitate the clearance of Aβ by enhancing microglial‐mediated phagocytosis through the upregulation of TREM2 expression.
Valentinus Besin, Farizky Martriano Humardani, Fenny Lanawati Yudiarto, Paulus Anam Ong, Sulistyo Emantoko Dwi Putra, Ratih Asmana Ningrum   +5 more
wiley   +1 more source

Affinity‐Based Protein Profiling Reveals IDH2 as a Mitochondrial Target of Cannabinol in Receptor‐Independent Neuroprotection

Chemistry – A European Journal, EarlyView.
A chemical probe CBN‐P based on the neuroprotective cannabinoid cannabinol (CBN) was developed and synthesized. CNB‐P was found to have a similar mechanism of action as the parent compound and was used in click‐CLEM microscopy studies and affinity‐based protein profiling to identify the mitochondrial protein isocitrate dehydrogenase 2 (IDH2) as one ...
Eva Schaller, Stephanie Lamer, Andreas Schlosser, Christian Stigloher, Pamela Maher, Michael Decker   +5 more
wiley   +1 more source

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques [PDF]

, 2016
Cella, Marina, Cirrito, John R, Colonna, Marco, et al,, Gilfillan, Susan, Holtzman, David M, Mahan, Thomas E, Shi, Yang, Song, Wilbur, Ulland, Tyler K, Ulrich, Jason D, Wang, Yaming   +11 more
core   +2 more sources

Development of Carborane‐Based Halogenated Naphthyridinone‐Analoga as Cannabinoid Receptor Type 2 (CB2R) Ligands

ChemMedChem, Accepted Article.
The cannabinoid receptor type 2 (CB2R) is overexpressed under pathological conditions. PET is a suitable non‐invasive imaging technique for diagnosing disease states, but requires a radiotracer that binds to CB2R with high affinity and selectivity. Currently, there is no suitable candidate routinely used in the clinics.
Lea Ueberham, Winnie Deuther-Conrad, Peter Lönnecke, Aleksandr Kazimir, Evamarie Hey-Hawkins   +4 more
wiley   +1 more source

The endocannabinoid system regulates both ependymoglial and neuronal cell responses to a tail amputation in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background The endocannabinoid system is a neuromodulatory system implicated in cellular processes during both development and regeneration. The Mexican axolotl, one of only a few vertebrates capable of central nervous system regeneration, was used to examine the role of the endocannabinoid system in the regeneration of the tail and spinal ...
Michael Tolentino, Sarah E. Walker, Gaynor E. Spencer, Robert Carlone   +3 more
wiley   +1 more source