Results 111 to 120 of about 235,228 (311)

Modulation and function of microglial phenotypes

, 2012
Microglia are the sentinel cells of the retina, where they are involved in surveillance of tissue integrity and clearance of cellular debris. The innate immune functions of microglia are tightly controlled by retinal neurons via the secretion of ...
Karlstetter, Marcus
core   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Noninvasive Quantification of Retinal Microglia Using Widefield Autofluorescence Imaging. [PDF]

, 2017
Purpose To validate widefield autofluorescence (AF) in vivo imaging of the retina in mice expressing green fluorescent protein (gfp) in microglia, and to monitor retinal microglia reconstitution in vivo after lethal irradiation and bone marrow ...
Martin Zinkernagel, Schneider, Nadia, Giannakaki-Zimmermann, Helena, Joel Jovanovic, Kokona, Despina, Nadia Schneider, Zinkernagel, Martin, Jovanovic, Joel, Despina Kokona, Andreas Ebneter, Helena Giannakaki-Zimmermann, Ebneter, Andreas   +11 more
core   +1 more source

Allogenic microglia replacement: A novel therapeutic strategy for neurological disorders

Fundamental Research
Microglia are resident immune cells in the central nervous system (CNS) that play vital roles in CNS development, homeostasis and disease pathogenesis.
Yanxia Rao, Bo Peng
doaj   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

PET Radioligands for in Vivo Visualization of Neuroinflammation. [PDF]

, 2014
Neuroinflammation is a well-orchestrated, dynamic, multicellular process playing a major role in neurodegenerative disorders. The microglia which make up the innate immune system of the central nervous system are key cellular mediators of ...
Ory, Dieter, Celeb, Sofie, Celen, Sofie, Verbruggen, Alfons, Bormans, Guy   +4 more
core   +1 more source

The role of microglia and their CX3CR1 signaling in adult neurogenesis in the olfactory bulb

eLife, 2017
Microglia play important roles in perinatal neuro- and synapto-genesis. To test the role of microglia in these processes during adulthood, we examined the effects of microglia depletion, via treatment of mice with the CSF-1 receptor antagonist PLX5622 ...
Ronen Reshef, Elena Kudryavitskaya, Haran Shani-Narkiss, Batya Isaacson, Neta Rimmerman, Adi Mizrahi, Raz Yirmiya   +6 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Microglial glutathione and glutamate: regulation mechanisms

, 2009
Microglia, the immune cells of the central nervous system (CNS), are important in the protection of the CNS, but may be implicated in the pathogenesis of neuroinflammatory disease.
Fry, V.A.H.
core  

Spatiotemporal analysis of impaired microglia process movement at sites of secondary neurodegeneration post-stroke

, 2019
It has recently been identified that after motor cortex stroke, the ability of microglia processes to respond to local damage cues is lost from the thalamus, a major site of secondary neurodegeneration (SND).
Kluge, Murielle G., Zalewska, Katarzyna, Ong, Lin Kooi, Walker, Frederick R., Nilsson, Michael, Abdolhoseini, Mahmoud, Johnson, Sarah J.   +6 more
core   +1 more source