Results 91 to 100 of about 235,228 (311)

Unsaponifiable and phenolic fractions from virgin olive oil prevent neuroinflammation skewing microglia polarization toward M2 phenotype

, 2019
Inhibiting M1 microglia phenotype while stimulating M2 microglia phenotype has been suggested as potential therapeutic approach for the treatment of neuroinflammation-related diseases.
Naranjo, María C., Claro Cala, Carmen María, Millán Linares, María del Carmen, Lemus Conejo, Ana, Toscano Sánchez, María del Rocío, Montserrat de la Paz, Sergio   +5 more
core   +1 more source

History of Microglia

The term 'microglia' was first introduced into the scientific literature a century ago. The various eras of microglial research have been defined not only by the number of reports subsequently generated but, more critically, also by the concepts that have shaped our present-day views and understanding of microglia. Key methods, technologies, and models,
Rezaie, Payam, Hanisch, Uwe-Karsten, Tremblay, Marie-Ève, Verkhratsky, Alexei   +3 more
openaire   +3 more sources

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Characterization of microglia diversity through live cell image analysis

, 2022
Trabajo presentado en el 19th National Meeting of the Spanish Society of Neuroscience, celebrado en Lleida (España), del 3 al 5 de noviembre de 2021Microglia are very sensitive to changes in the environment and respond through morphological ...
Bosch, Anna, Calvo, María, Tischer, Christian, Otxoa de Amezaga, Amaia, Petegnief, Valérie, Martinez, Aleix, Hériché, Jean-Karim, Planas, Anna M.   +7 more
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Microglia-Based Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective in Alzheimer’s Disease Models

, 2016
Currently, anti-AD drug discovery using target-based approaches is extremely challenging due to unclear etiology of AD and absence of validated therapeutic protein targets.
Luyi Li (449409), Guifa Zhong (2026414), Xing Ji (3096735), Sihai Fu (3096738), Dengfeng Xu (2550688), Xiaorong Liu (239247), Xiurong Rao (2026417), Micky Tortorella (3014235), Tianyan Chi (2026423), Wei Zhou (24328), Donghai Wu (309245), Hui Xie (195238), Shaogao Zeng (2026426), Wenhui Hu (80326), Guoqing Sheng (3096741), Hao Wang (39217), Xuefei Ji (3096744), Libo Zou (2026420), Kejian Zhang (2381038)   +18 more
core   +1 more source

scRNA-Seq reveals age-dependent microglial evolution as a determinant of immune response following spinal cord injury

Brain Research Bulletin
Spinal cord injury (SCI) is a debilitating condition of the central nervous system (CNS) that leads to severe impairments in sensory and motor functions.
Lufei Shao, Yueliang Chang, Jinfang Liu, Leilei Lin, Long Chang, Jialin Zhang, Zhibin Lan, Honglai Zhang, Xiaolei Chen   +8 more
doaj   +1 more source

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source

Investigating a novel microglial phenotype in a genetic model of Parkinson's Disease

, 2022
noneMicroglia are the brain resident immune cells. They play a key role in protecting the central nervous system as well as in maintaining its homeostasis.
KAUR, GURKIRAT
core  

Effects of early-life immune activation on microglia-mediated synapse remodeling and hippocampal-dependent learning in the juvenile rat

, 2020
Schwarz, Jaclyn M.Jaremka, Lisa M.Dysregulation of the immune system during childhood leads to an increased risk for a number of neurodevelopmental disorders including autism spectrum disorders (ASD), attention deficit hyperactivity disorder (ADHD), and ...
Osborne, Brittany F.
core   +1 more source