Results 131 to 140 of about 237,619 (355)
Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain
Advanced Science, EarlyView.Ce‐UiO‐66‐Bupivacaine (CUB) demonstrates triple therapeutic innovation: 1) Sustained analgesia with ROS scavenging synergistically resolves neuropathic pain; 2) Microglia/astrocyte polarization switch reprograms the pro‐regenerative immune microenvironment; 3) CGRP‐TSP‐1 axis activation couples inflammation suppression to axon regeneration, defining a ...
Yue Wang +9 more
wiley +1 more source
NeurogliaMicroglia are poorly understood immune cells of the central nervous system that play a determining role in the progression of multiple sclerosis. With the advent of genomic techniques such as single-cell RNA sequencing and single-nucleus RNA sequencing ...
Akanksha Jha, Hemant Kumar
doaj +1 more source
Neurotrophic Factors Regulate Cathepsin S in Macrophages and Microglia: A Role in the Degradation of Myelin Basic Protein and Amyloid β Peptide [PDF]
, 1999 John P. Liuzzo +2 more
openalex +1 more source
Mechanotransduction Activates Microglia and Impairs Phagocytosis in Stiff Amyloid‐β Plaques
Advanced Science, EarlyView.The study constructs an in vitro Aβ plaque‐associated microglia model and uses SECM and SICM to in situ monitor changes in ROS levels, membrane permeability, and phagocytosis of microglia during Aβ clearance. It is found out that Aβ stiffness triggers microglial activation via the PIEZO1 mechanotransduction pathway, causing neuroinflammation and ...
Yulin Liu +8 more
wiley +1 more source
Microglia-Derived Nerve Growth Factor Causes Cell Death in the Developing Retina [PDF]
, 1998 José M. Frade, Yves‐Alain Barde
openalex +1 more source
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
Advanced Science, EarlyView.During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong +9 more
wiley +1 more source
Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging
Journal of NeuroinflammationMicroglia, the brain’s resident macrophages, maintain brain homeostasis and respond to injury and infection. During aging they undergo functional changes, but the underlying mechanisms and their contributions to neuroprotection versus neurodegeneration ...
Seokjo Kang +9 more
doaj +1 more source
Advanced Science, EarlyView.This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song +15 more
wiley +1 more source
MICROGLIA: AN EXPERIMENTAL STUDY IN RABBITS AFTER INTRACEREBRAL INJECTION OF BLOOD
, 1929 E. A. Carmichael
openalex +1 more source
Activation of p38MAPK in Microglia After Ischemia [PDF]
, 1998 Kevin M. Walton +7 more
openalex +1 more source