Results 131 to 140 of about 388,044 (340)

The Role of Microglia in Neuroinflammation of the Spinal Cord after Peripheral Nerve Injury [PDF]

, 2022
Tana S. Pottorf, Travis M. Rotterman, William M. McCallum, Zoë A. Haley-Johnson, Francisco J. Álvarez   +4 more
openalex   +1 more source

Methotrexate‐Loaded Liposomal Formulation Enables 6‐Week Sustained Intraocular Therapeutic Drug Release in a Porcine Model

Advanced Healthcare Materials, EarlyView.
A liposomal formulation for methotrexate enables minimally invasive, sustained intraocular drug delivery for over six weeks with a single injection. Developed for treating intraocular diseases like lymphoma and PVR, it offers excellent biocompatibility in vivo in a porcine model.
Maximilian Hammer, Lea Skrzypczyk, Sabrina Wohlfart, Bryan Calder Ackermann, Ludwig Geisweid, Simon William Pohl, Margarita Karaivanova, Jonathan Herth, Victor Aristide Augustin, Alexander Studier‐Fischer, Tina Sackmann, Leon Kaulen, Anna Steyer, Walter Mier, David H Steel, Kanmin Xue, Gerd Uwe Auffarth, Philipp Uhl   +17 more
wiley   +1 more source

Protective microglia and its regulation in Parkinson's disease

Frontiers in Molecular Neuroscience, 2016
Microglia mediated neuroinflammation is a hallmark of Parkinson’s disease (PD). It has been reported that microglia in the brain of PD have both neurotoxic and neuroprotective effects, depending on the microglial activation states.
Weidong Le, Junjiao Wu, Junjiao Wu, Yu Tang, Yu Tang   +4 more
doaj   +1 more source

Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury. [PDF]

, 2012
OBJECTIVE: This study tests the hypothesis that injury to the somatosensory cortex is associated with periorbital allodynia and increases in nociceptive neuropeptides in the brainstem in a mouse model of controlled cortical impact (CCI) injury.
Amenta, Peter S., Awe, Olatilewa, Elliott, Melanie B., Jallo, Jack I., Oshinsky, Michael L.   +4 more
core   +2 more sources

Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia [PDF]

, 2021
Diana P. Benítez, Shenyi Jiang, Jack Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Natalie Wong, Katie Stringer, Karina S. Vitanova, Victoria Smith, Dhaval Joshi, Takashi Saito, Takaomi C. Saido, John Hardy, Jörg Hanrieder, Bart De Strooper, Derviş A. Salih, Takshashila Tripathi, Frances A. Edwards, Damian M. Cummings   +19 more
openalex   +1 more source

Microglia states and nomenclature: A field at its crossroads

Neuron, 2022
R. Paolicelli, A. Sierra, B. Stevens, M. Tremblay, A. Aguzzi, Bahareh Ajami, I. Amit, E. Audinat, I. Bechmann, Mariko L. Bennett, Frederick Bennett, A. Bessis, K. Biber, S. Bilbo, M. Blurton-Jones, E. Boddeke, D. Brites, B. Brône, Guy C. Brown, O. Butovsky, M. Carson, B. Castellano, M. Colonna, S. Cowley, C. Cunningham, Dimitrios Davalos, P. D. De Jager, B. de Strooper, Á. Dénes, B. Eggen, Ukpong B. Eyo, E. Galea, S. Garel, F. Ginhoux, Christopher K. Glass, O. Gokce, D. Gomez-Nicola, B. González, Siamon Gordon, M. Graeber, A. Greenhalgh, P. Gressens, M. Greter, D. Gutmann, C. Haass, M. Heneka, F. Heppner, Soyon Hong, David A. Hume, Steffen Jung, H. Kettenmann, J. Kipnis, R. Koyama, G. Lemke, Marina A. Lynch, A. Majewska, M. Malcangio, T. Malm, R. Mancuso, Takahiro Masuda, M. Matteoli, B. McColl, V. Miron, A. Molofsky, M. Monje, E. Mracsko, A. Nadjar, J. Neher, Urte Neniskyte, H. Neumann, M. Noda, Bo Peng, F. Peri, V. Perry, P. Popovich, Clare Pridans, Josef Priller, M. Prinz, D. Ragozzino, R. Ransohoff, M. Salter, A. Schaefer, D. Schafer, M. Schwartz, M. Simons, Cody Smith, W. Streit, Tuan Leng Tay, L. Tsai, A. Verkhratsky, R. von Bernhardi, H. Wake, V. Wittamer, S. Wolf, Long-Jun Wu, T. Wyss-Coray   +95 more
semanticscholar   +1 more source

Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brain

bioRxiv, 2019
Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases.
J. Marschallinger, Tal Iram, Macy E. Zardeneta, S. Lee, B. Lehallier, Michael S. Haney, John V. Pluvinage, Vidhu K. Mathur, Oliver Hahn, D. Morgens, Justin Kim, J. Tevini, T. Felder, H. Wolinski, C. Bertozzi, M. Bassik, L. Aigner, T. Wyss-Coray   +17 more
semanticscholar   +1 more source

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo

Advanced Materials, EarlyView.
Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll, Marc‐Joseph Antonini, Taylor M. Cannon, Pema Maretich, Greatness Olaitan, Valerie Doan Phi Van, Keisuke Nagao, Atharva Sahasrabudhe, Emmanuel Vargas Paniagua, Ethan J. Frey, Ye Ji Kim, Sydney Hunt, Melissa Hummel, Sanju Mupparaju, Alan Jasanoff, B. Jill Venton, Polina Anikeeva   +16 more
wiley   +1 more source

Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging

Journal of Neuroinflammation
Microglia, the brain’s resident macrophages, maintain brain homeostasis and respond to injury and infection. During aging they undergo functional changes, but the underlying mechanisms and their contributions to neuroprotection versus neurodegeneration ...
Seokjo Kang, Emily Y. Ko, Amelia E. Andrews, Juliana E. Shin, Karina J. Nance, Pijus K. Barman, Peter S. Heeger, Willard M. Freeman, Bérénice A. Benayoun, Helen S. Goodridge   +9 more
doaj   +1 more source

Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia [PDF]

, 2022
Boyd Kenkhuis, Michelle van Eekeren, David A. Parfitt, Yavuz Ariyürek, Poulomi Banerjee, Josef Priller, Louise van der Weerd, Willeke M. C. van Roon‐Mom   +7 more
openalex   +1 more source