Results 131 to 140 of about 174,983 (281)

Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles

Advanced Science, EarlyView.
Recent studies highlighted the heterogeneity of EVs and the influence of microenvironmental signals on their therapeutic efficacy. This review offers a comprehensive overview of strategies and mechanisms to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation.
Bilu Xiang, Shiying Zhang, Irene Shuping Zhao, Xueqi Gan, Yang Zhang   +4 more
wiley   +1 more source

scRNA-Seq reveals age-dependent microglial evolution as a determinant of immune response following spinal cord injury

Brain Research Bulletin
Spinal cord injury (SCI) is a debilitating condition of the central nervous system (CNS) that leads to severe impairments in sensory and motor functions.
Lufei Shao, Yueliang Chang, Jinfang Liu, Leilei Lin, Long Chang, Jialin Zhang, Zhibin Lan, Honglai Zhang, Xiaolei Chen   +8 more
doaj  

Neurotrophic Factors Regulate Cathepsin S in Macrophages and Microglia: A Role in the Degradation of Myelin Basic Protein and Amyloid β Peptide [PDF]

, 1999
John P. Liuzzo, Suzana Petanceska, Lakshmi A. Devi   +2 more
openalex   +1 more source

Loss of tumor necrosis factor (TNF)‐receptor 1 and TNF‐receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus

Journal of Comparative Neurology, Volume 531, Issue 2, Page 281-293, February 2023., 2023
Hippocampal granule cells of adult mice lacking canonical TNF‐Rs were filled with Alexa568 and immunolabeled for Synaptopodin. Morphometric analysis of their spines revealed that TNF‐R mutants partially replicate changes previously reported for TNF‐deficient mice.
Dinko Smilovic, Michael Rietsche, Meike Fellenz, Alexander Drakew, Mario Vuksic, Thomas Deller   +5 more
wiley   +1 more source

Comparison and quantitation of Ia antigen expression on cultured macroglia and ameboid microglia from Lewis rat cerebral cortex: analyses and implications

, 1989
Atsushi Sasaki, Steven W. Levison, Jenny P.‐Y. Ting   +2 more
openalex   +2 more sources

Late virus replication events in microglia are required for neurovirulent retrovirus-induced spongiform neurodegeneration: evidence from neural progenitor-derived chimeric mouse brains [PDF]

, 1996
William P. Lynch, E.Y. Snyder, Louis F. Qualtiere, John L. Portis, Arlene H. Sharpe   +4 more
openalex   +1 more source

HDL‐Apolipoprotein in Alzheimer's Disease Revisited: From Periphery to CNS

AGING MEDICINE, EarlyView.
HDL‐apolipoproteins in the periphery and CNS contribute differently to Alzheimer's disease, influencing Aβ, p‐tau, brain structures, and cognition. Apolipoprotein AI and E, key HDL components in blood and CSF, may either protect against or accelerate AD, depending on their location. Created with BioGDP.com. ABSTRACT High‐density lipoprotein (HDL), as a
Yihong Huang, Jingyi Tang, Guohua Chen, Qiangqiang Wu, Yongfei Wang, Jianjun Chen, Simei Chen, Jun Liu, Xiaoyun Huang   +8 more
wiley   +1 more source

Cell morphologies in the nervous system: Glia steal the limelight

Journal of Comparative Neurology, Volume 531, Issue 3, Page 338-343, February 2023., 2023
Diversity of digitally reconstructed glia (astrocytes, oligodendrocytes, microglia, and other types) freely available for download and reuse at NeuroMorpho.Org in terms of experimental provenance, animal species, anatomical region, cell type, tracing platform, and more.
Giorgio A. Ascoli
wiley   +1 more source

Human Immunodeficiency Virus Neurotropism: an Analysis of Viral Replication and Cytopathicity for Divergent Strains in Monocytes and Microglia [PDF]

, 1998
Anuja Ghorpade, Adeline Nukuna, Myhanh Che, Sheryl Haggerty, Yuri Persidsky, Eboni Carter, Leeroy Carhart, Laura Shafer, Howard E. Gendelman   +8 more
openalex   +1 more source

Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease

Aggregate, EarlyView.
This review introduces the light‐regulated Aβ aggregation, highlighting four applications: photodynamic therapy (PDT), photothermal therapy (PTT), photopharmacology, and photobiomodulation (PBM) systems. It also summarizes the current issues and proposes the prospects of photo‐induced modulation of Aβ aggregation and clearance as a therapeutic strategy
Yunhua Zhang, Chengyuan Qian, Yuncong Chen, Weijiang He, Zijian Guo   +4 more
wiley   +1 more source