Advanced Science, EarlyView.We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich +8 more
wiley +1 more source
Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder
Advanced Science, EarlyView.The cGAS‐STING innate immune pathway is excessively activated both in peripheral monocytes and CNS microglia in patients with NMOSD, leading to an overproduction of IFN‐I. IFN‐I subsequently acts on AQP4‐specific autoreactive T cells. Blocking this pathway may offer novel therapeutic options for individuals with NMOSD.
Tian‐Xiang Zhang +13 more
wiley +1 more source
Weight Cycling Deregulates Eating Behavior in Mice via the Induction of Durable Gut Dysbiosis
Advanced Science, EarlyView.Weight cycling in Humans is suspected to dysregulate eating behavior. Mice submitted to body weight cycling by alternating western‐type and regular chow diets display increased hedonic appetite when exposed to a palatable diet, reminiscent of binge‐eating episodes.
Mélanie Fouesnard +13 more
wiley +1 more source
Mannose Receptor and Its Putative Ligands in Normal Murine Lymphoid and Nonlymphoid Organs: In Situ Expression of Mannose Receptor by Selected Macrophages, Endothelial Cells, Perivascular Microglia, and Mesangial Cells, but not Dendritic Cells [PDF]
, 1999 Sheena A. Linehan +3 more
openalex +1 more source
Advanced Science, EarlyView.This study reports for the first time an oral targeted nanomedicine that conducts ion exchange through engineered Ganoderma‐derived extracellular vesicle, managing both the in‐copper and ex‐copper in a multi‐pronged approach, offering a promising therapeutic strategy for addressing WD with reproductive dysfunction.
Tingting Wang +12 more
wiley +1 more source
Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat [PDF]
, 1995 D. Scott Stephenson +5 more
openalex +1 more source
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Science, 2010 F. Ginhoux +12 more
semanticscholar +1 more source
Advanced Science, EarlyView.24p3R is an astrocytic receptor for α‐Syn uptake. When LCN2 is secreted from astrocytes, it binds to its receptor 24p3R in astrocytes and this binding impedes the α‐Syn PFF binding to 24p3R. This in turn inhibits 24p3R‐mediated α‐Syn PFF uptake and reduces the clearance of extracellular α‐Syn by astrocytes, which contributes to α‐Syn spread and ...
Ying‐Ying Jiao +14 more
wiley +1 more source
Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging
Journal of NeuroinflammationMicroglia, the brain’s resident macrophages, maintain brain homeostasis and respond to injury and infection. During aging they undergo functional changes, but the underlying mechanisms and their contributions to neuroprotection versus neurodegeneration ...
Seokjo Kang +9 more
doaj +1 more source
Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance
Advanced Science, EarlyView.Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai +5 more
wiley +1 more source