Results 161 to 170 of about 237,619 (355)

Neurotoxic reactive astrocytes are induced by activated microglia

Nature, 2017
S. A. Liddelow, Kevin A. Guttenplan, Laura E. Clarke, F. C. Bennett, Christopher J. Bohlen, Lucas Schirmer, Mariko L Bennett, Alexandra E. Münch, Won-Suk Chung, Todd C. Peterson, D. Wilton, A. Frouin, Brooke A. Napier, Nikhil Panicker, Manoj Kumar, M. Buckwalter, D. Rowitch, V. Dawson, Ted M. Dawson, Beth Stevens, B. Barres   +20 more
semanticscholar   +1 more source

PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

Advanced Science, EarlyView.
This study identifies PRMT3‐mediated H4R3me2a as a critical driver of tau hyperphosphorylation in primary age‐related tauopathy. Mechanistic insights reveal that the PRMT3/H4R3me2a/miR‐448 axis suppresses IGF1R expression via epigenetic regulation, further dysregulating the PI3K/AKT/GSK3β pathway.
Haotian Liu, Xinnan Liu, Fengyuan Tian, Yashuang Chen, Jingying Li, Xue Wang, Wenying Qiu, Xia Wang, Chao Ma, Wei Ge   +9 more
wiley   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

Microglia heterogeneity in health and disease

FEBS Open Bio
Microglia, the resident immune cells of the central nervous system (CNS), have received significant attention due to their critical roles in maintaining brain homeostasis and mediating cerebral immune responses.
Shilauni Dadwal, Michael T. Heneka
doaj   +1 more source

Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers

, 1990
A. Sasaki, S.W. Levison, J.P.-Y. Ting
openalex   +2 more sources

Cytokine Induction of MIP-1α and MIP-1β in Human Fetal Microglia [PDF]

, 1998
Carrie M. McManus, Celia F. Brosnan, Joan W. Berman   +2 more
openalex   +1 more source

Host microbiota constantly control maturation and function of microglia in the CNS

Nature Neuroscience, 2015
Daniel Erny, Anna Lena Hrabě de Angelis, Diego Jaitin, Peter Wieghofer, O. Staszewski, Eyal David, Hadas Keren-Shaul, Tanel Mahlakõiv, Kristin Jakobshagen, T. Buch, V. Schwierzeck, O. Utermöhlen, Eunyoung Chun, W. Garrett, K. McCoy, A. Diefenbach, P. Staeheli, B. Stecher, I. Amit, M. Prinz   +19 more
semanticscholar   +1 more source

Magnetically Controllable and Degradable Milliscale Swimmers as Intraocular Drug Implants

Advanced Science, EarlyView.
Magnetically controllable degradable milliscale swimmers (MDMS) offer a promising alternative to commercial intraocular drug implants, reducing complications like implant dislocation and uncontrolled drug release. MDMS achieve high velocities in ocular environments, enable real‐time imaging, and deliver drugs effectively without disrupting retinal ...
Erdost Yildiz, Ugur Bozuyuk, Eray Yildiz, Fan Wang, Mertcan Han, Alp Can Karacakol, Devin Sheehan, Yan Yu, Metin Sitti   +8 more
wiley   +1 more source

Microglia reaction on the neurotoxic effect of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in the nigrostriatal pathway in mice

, 1994
Anna Członkowska, Małgorzata Kohutnicka, I. Kurkowska-Jastreȩbska, Andrzej Członkowski   +3 more
openalex   +1 more source

Late virus replication events in microglia are required for neurovirulent retrovirus-induced spongiform neurodegeneration: evidence from neural progenitor-derived chimeric mouse brains [PDF]

, 1996
William P. Lynch, E.Y. Snyder, Louis F. Qualtiere, John L. Portis, Arlene H. Sharpe   +4 more
openalex   +1 more source