Results 161 to 170 of about 242,823 (354)

Clinical Features, Molecular Biology, and the Metastatic Microenvironment in Lung Cancer Brain Metastases: Implications for Treatment Decisions

Advanced Science, EarlyView.
Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu, Danming He, Zan Hou, Mei Lan, Ye Zhang, Qifeng Wang   +5 more
wiley   +1 more source

Phosphatidylserine-dependent phagocytosis of apoptotic glioma cells by normal human microglia, astrocytes, and glioma cells [PDF]

, 2000
Grace H.-F. Chang, Nicholas M. Barbaro, Russell O. Pieper   +2 more
openalex   +2 more sources

Human Immunodeficiency Virus Neurotropism: an Analysis of Viral Replication and Cytopathicity for Divergent Strains in Monocytes and Microglia [PDF]

, 1998
Anuja Ghorpade, Adeline Nukuna, Myhanh Che, Sheryl Haggerty, Yuri Persidsky, Eboni Carter, Leeroy Carhart, Laura Shafer, Howard E. Gendelman   +8 more
openalex   +1 more source

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

Advanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu, Jia Chen, Fangzhou Wang, Dongdong Jia, Shuguang Bi, Yuming Mao, Yu‐qi Zhang, Tian‐long Gao, Liu Yang, Jia‐xu Du, Zi‐han Zhou, Xi‐Chen Zhu, Gao‐shang Chai   +12 more
wiley   +1 more source

Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression

, 1994
Akio Suzumura, Makoto Sawada, Yasuhiro Itoh, Tohru Marunouchi   +3 more
openalex   +1 more source

Identification of Cellular Compartments Involved in Processing of Cathepsin E in Primary Cultures of Rat Microglia [PDF]

, 1998
Dewi Fatma Suniarti Sastradipura, Hiroshi Nakanishi, Takayuki Tsukuba, Kazuhisa Nishishita, Hideaki Sakai, Yuzo Kato, Takahiro Gotow, Yasuo Uchiyama, Kenji Yamamoto   +8 more
openalex   +1 more source

Parvalbumin Interneuron‐Dependent Hippocampal Neurogenesis Evoked by Prolonged Rhythmic Light Flicker

Advanced Science, EarlyView.
This study demonstrates that prolonged rhythmic 40 Hz light flicker enhances spatial learning by stimulating PV interneuron‐dependent neurogenesis. The light flicker selectively activates PV interneurons, which enhances GABAergic support for the integration of immature neurons in the adult dentate gyrus.
Hai Yan, Yunxuan Wang, Xufan Deng, Shiyu Wu, Yifan Pan, Jun Du, Mei Yu, Bo Liu, Huimei Wang, Zhengyu Zhang, Jinghong Chen, Shuifa Chen, Yizheng Wang, Tara Walker, Perry Bartlett, Jun Ju, Sheng‐Tao Hou   +16 more
wiley   +1 more source

Host microbiota constantly control maturation and function of microglia in the CNS

Nature Neuroscience, 2015
Daniel Erny, Anna Lena Hrabě de Angelis, Diego Jaitin, Peter Wieghofer, O. Staszewski, Eyal David, Hadas Keren-Shaul, Tanel Mahlakõiv, Kristin Jakobshagen, T. Buch, V. Schwierzeck, O. Utermöhlen, Eunyoung Chun, W. Garrett, K. McCoy, A. Diefenbach, P. Staeheli, B. Stecher, I. Amit, M. Prinz   +19 more
semanticscholar   +1 more source

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

Advanced Science, EarlyView.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source

Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers

, 1990
A. Sasaki, S.W. Levison, J.P.-Y. Ting
openalex   +2 more sources