Results 161 to 170 of about 174,983 (281)

Early functional and structural hippocampal impairment in a bilateral common carotid artery stenosis mouse model

Animal Models and Experimental Medicine, EarlyView.
Our study used behavioral tests, laser speckle flowmetry, long‐term potentiation, histochemical staining, molecular experiments, and voxel‐based morphometry to evaluate the hippocampal impairments. It demonstrates early functional and structural impairments in the hippocampus contributing to learning and memory deficits after 1 month of BCAS ...
Ping Tang, Yi Sun, Chunsheng Yang, Nan Zhang   +3 more
wiley   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

Contribution of Microglia/Macrophages to Expansion of Infarction and Response of Oligodendrocytes After Focal Cerebral Ischemia in Rats [PDF]

, 2000
Takuma Mabuchi, Kazuo Kitagawa, Toshiho Ohtsuki, Keisuke Kuwabara, Yoshiki Yagita, Takehiko Yanagihara, Masatsugu Hori, Masayasu Matsumoto   +7 more
openalex   +1 more source

The NLRP3 inflammasome pathway contributes to chronic inflammation in experimental autoimmune uveitis

Animal Models and Experimental Medicine, EarlyView.
The present study investigates the role of the NLRP3 inflammasome in the chronicity of ocular inflammation in uveitis using the experimental autoimmune uveitis (EAU) model. Whole eyes collected from EAU mice, 12 weeks post induction, were sectioned and subjected to immunohistochemistry. The confocal images from these sections were then assessed for the
Avik Shome, Ilva D. Rupenthal, Rachael L. Niederer, Odunayo O. Mugisho   +3 more
wiley   +1 more source

The dual role of microglia in Alzheimer's disease: from immune regulation to pathological progression. [PDF]

Front Aging Neurosci
He C, Chen B, Yang H, Zhou X.
europepmc   +1 more source

Graded expression of immunomolecules on activated microglia in the hippocampus following ischemia in a rat model of ischemic tolerance

, 1995
Hiroyuki Kato, Kyuya Kogure, Tsutomu Araki, Yasuto Itoyama   +3 more
openalex   +1 more source

Potentiation of a Voltage-Gated Proton Current in Acidosis-Induced Swelling of Rat Microglia [PDF]

, 2000
Hirokazu Morihata, Fusao Nakamura, Tsuyoshi Tsutada, Miyuki Kuno   +3 more
openalex   +1 more source

Krüppel‐like factor 4 transcription factor in blood–brain barrier endothelial cells: A potential role in Alzheimer's disease

Animal Models and Experimental Medicine, EarlyView.
KLF4 (Krüppel‐like factor 4) plays a protective role in blood–brain barrier (BBB). KLF4 plays an ambiguous role in the central nervous system. KLF4 in the BBB endothelial cells could be a potential target for Alzheimer's disease. Abstract Alzheimer's disease is the most prevalent chronic neurodegenerative disorder worldwide, with no sufficient cure ...
Ziying Wei, Chunhua Liu, Jianyu Chen, Yuxiao Yao, Dajiang Qin   +4 more
wiley   +1 more source

APOE4 impairs autophagy and Aβ clearance by microglial cells. [PDF]

Inflamm Res
Bassal R, Rivkin-Natan M, Rabinovich A, Michaelson DM, Frenkel D, Pinkas-Kramarski R.   +5 more
europepmc   +1 more source

Subventricular Zone Microstructure in Pediatric‐Onset Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective The aim of this study was to explore the microstructural dynamics of the subventricular zone (SVZ) with aging and their associations with clinical disability and brain structural damage in pediatric‐onset multiple sclerosis (MS) patients. Methods One‐hundred and forty‐one pediatric‐onset MS patients (67 pediatric and 74 adults with pediatric ...
Monica Margoni, Loredana Storelli, Elisabetta Pagani, Paolo Preziosa, Damiano Mistri, Mor Gueye, Martina Rubin, Lucia Moiola, Massimo Filippi, Maria Assunta Rocca   +9 more
wiley   +1 more source