Results 11 to 20 of about 193,226 (120)

Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia

Cell Reports, 2019
Summary: Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity. However, the signaling pathways and environmental cues that drive diverse states of microglia are incompletely ...
Sarah R. Anderson, Jacqueline M. Roberts, Jianmin Zhang, Michael R. Steele, Cesar O. Romero, Alejandra Bosco, Monica L. Vetter   +6 more
doaj   +1 more source

Microglia actively regulate the number of functional synapses. [PDF]

PLoS ONE, 2013
Microglia are the immunocompetent cells of the central nervous system. In the physiological setting, their highly motile processes continually survey the local brain parenchyma and transiently contact synaptic elements.
Kyungmin Ji, Gulcan Akgul, Lonnie P Wollmuth, Stella E Tsirka   +3 more
doaj   +1 more source

Microglia replacement by bone marrow transplantation (Mr BMT) in the central nervous system of adult mice

STAR Protocols, 2021
Summary: Microglia are important immune cells in the central nervous system (CNS). Mutations in microglia may cause CNS disorders. Replacement of dysfunctional microglia with allogeneic wild-type microglia can correct the gene deficiency, thus treating ...
Zhen Xu, Xin Zhou, Bo Peng, Yanxia Rao
doaj   +1 more source

Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia

Mediators of Inflammation, 2017
Microglia play an important role in mediating inflammatory processes in the central nervous system (CNS). Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor and could decrease neuropathology in Alzheimer’s disease ...
Xiaobao Zhang, Fang Yan, Jizheng Cui, Yong Wu, Hengfei Luan, Miaomiao Yin, Zhibin Zhao, Jiying Feng, Jinwei Zhang   +8 more
doaj   +1 more source

The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function

Journal of Neuroinflammation, 2020
Background Microglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia polarize towards different phenotypes.
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Helena Monière, Igor Jakovcevski, Pavle Andjus, Dunja Bijelic, Stefan Blaschke, Helene Luise Walter, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger   +11 more
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New insight on microglia activation in neurodegenerative diseases and therapeutics

Frontiers in Neuroscience, 2023
Microglia are immune cells within the central nervous system (CNS) closely linked to brain health and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
Yucong Xu, Yucong Xu, Wei Gao, Wei Gao, Yingnan Sun, Minghua Wu, Minghua Wu   +6 more
doaj   +1 more source

Advances in Visualizing Microglial Cells in Human Central Nervous System Tissue

Biomolecules, 2022
Neuroinflammation has recently been identified as a fundamentally important pathological process in most, if not all, CNS diseases. The main contributor to neuroinflammation is the microglia, which constitute the innate immune response system.
Christopher E. G. Uff, Karishma Patel, Charming Yeung, Ping K. Yip   +3 more
doaj   +1 more source

Comparing the Characteristics of Microglia Preparations Generated Using Different Human iPSC-Based Differentiation Methods to Model Neurodegenerative Diseases

ASN Neuro, 2022
As the resident immune cells of the healthy nervous system, homeostatic microglia can rapidly become activated in response to injury/disease. Dysregulated microglia activation is a hallmark of nervous system disorders including neurodegenerative diseases
Ye Man Tang, Nisha S. Pulimood, Stefano Stifani   +2 more
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A richer and more diverse future for microglia phenotypes

Heliyon, 2023
Microglia are the only resident innate immune cells derived from the mesoderm in the nerve tissue. They play a role in the development and maturation of the central nervous system (CNS).
Jie Wang, Wenbin He, Junlong Zhang
doaj   +1 more source

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

Cell Reports, 2013
Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo ...
Isaac M. Chiu, Emiko T.A. Morimoto, Hani Goodarzi, Jennifer T. Liao, Sean O’Keeffe, Hemali P. Phatnani, Michael Muratet, Michael C. Carroll, Shawn Levy, Saeed Tavazoie, Richard M. Myers, Tom Maniatis   +11 more
doaj   +1 more source