Results 11 to 20 of about 315,527 (297)
The role of microglia in Alzheimer's disease and progress of treatment
Ibrain, 2022 Microglia are permanent immune cells of the central nervous system. Microglia play an important role in the pathological process of Alzheimer's disease (AD). They are mainly involved in the uptake and clearance of amyloid‐β (Aβ), as well as the formation
Yi‐Huan Guan +6 more
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Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]
, 2019 In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María +13 more
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Post-ischaemic immunological response in the brain: targeting microglia in ischaemic stroke therapy [PDF]
, 2020 Microglia, the major endogenous immune cells of the central nervous system, mediate critical degenerative and regenerative responses in ischaemic stroke.
Chen, Ruoli +4 more
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Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosis [PDF]
, 2020 Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron degeneration in adults, and several mechanisms underlying the disease pathology have been proposed.
Christoforidou, Eleni +2 more
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Expression and role of triggering receptor expressed on myeloid cells 2 in high glucose-treated microglia [PDF]
Jichu yixue yu linchuangObjective To explore the expression of triggering receptor expressed on myeloid cells 2 (TREM2) in high-glucose microglia and to investigate the role of TREM2 in the proliferation, migration and phagocytosis of high-glucose microglia.
WANG Zhaohui, LIU Xiao, ZHOU Yue, WEI Xinyi, WANG Yue, LI Junfa, ZHAO Li
doaj +1 more source
Metabolic Brain Disease, 2004 Microglia--the macrophage equivalent of the CNS--safeguards and supports neuronal functions. Threats to the CNS homeostasis can trigger a rapid transformation of these cells from a normally "resting" into alerted and "activated" states. Microglia primarily serves the tissue defence and protection when participating in mechanisms of innate and adaptive ...
van Rossum, Denise, Hanisch, Uwe-Karsten
openaire +3 more sources
Cell Reports, 2019 Summary: Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity. However, the signaling pathways and environmental cues that drive diverse states of microglia are incompletely ...
Sarah R. Anderson +6 more
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ASN Neuro, 2022 As the resident immune cells of the healthy nervous system, homeostatic microglia can rapidly become activated in response to injury/disease. Dysregulated microglia activation is a hallmark of nervous system disorders including neurodegenerative diseases
Ye Man Tang +2 more
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Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits. [PDF]
, 2018 Microglia are the main immune component in the brain that can regulate neuronal health and synapse function. Exposure to cosmic radiation can cause long-term cognitive impairments in rodent models thereby presenting potential obstacles for astronauts ...
Campbell-Beachler, Mary +10 more
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Microglia-Derived Microvesicles Affect Microglia Phenotype in Glioma [PDF]
Frontiers in Cellular Neuroscience, 2019 Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic acids. In the nervous system, EVs participate to neuron-glial cross-talk, a bidirectional communication important to ...
Alfonso Grimaldi +14 more
openaire +5 more sources