Results 31 to 40 of about 193,226 (120)

Rod microglia: a morphological definition. [PDF]

PLoS ONE, 2014
Brain microglial morphology relates to function, with ramified microglia surveying the micro-environment and amoeboid microglia engulfing debris. One subgroup of microglia, rod microglia, have been observed in a number of pathological conditions, however
Samuel E Taylor, Cristina Morganti-Kossmann, Jonathan Lifshitz, Jenna M Ziebell   +3 more
doaj   +1 more source

Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals

eLife
Microglia are brain-resident macrophages playing pivotal roles in central nervous system (CNS) development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance remains largely unknown.
Yi Wu, Weilin Guo, Haoyue Kuang, Xiaohai Wu, Thi Huong Trinh, Yuexin Wang, Shizheng Zhao, Zilong Wen, Tao Yu   +8 more
doaj   +1 more source

Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB

Molecular Neurodegeneration
Background Microglia play crucial roles in maintaining neuronal homeostasis but have been implicated in contributing to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Benjamin E. Clarke, Oliver J. Ziff, Giulia Tyzack, Marija Petrić Howe, Yiran Wang, Pierre Klein, Claudia A. Smith, Cameron A. Hall, Adel Helmy, Michael Howell, Gavin Kelly, Rickie Patani   +11 more
doaj   +1 more source

Downregulation of PIK3IP1 in retinal microglia promotes retinal pathological neovascularization via PI3K-AKT pathway activation

Scientific Reports, 2023
Retinal pathological neovascularization involves endothelial cells, pericytes, photoreceptor cells, ganglion cells, and glial cells, whose roles remain unclear.
Lushu Chen, Yuan Cao, Yaming Shen, Huan Li, Rong Ye, Jin Yao   +5 more
doaj   +1 more source

A Custom Panel for Profiling Microglia Gene Expression

Cells
Despite being immune cells of the central nervous system (CNS), microglia contribute to CNS development, maturation, and homeostasis, and microglia dysfunction has been implicated in several neurological disorders.
Phani Sankar Potru, Natascha Vidovic, Susanne Wiemann, Tamara Russ, Marcel Trautmann, Björn Spittau   +5 more
doaj   +1 more source

Aged lipid‐laden microglia display impaired responses to stroke

EMBO Molecular Medicine, 2022
Microglial cells of the aged brain manifest signs of dysfunction that could contribute to the worse neurological outcome of stroke in the elderly. Treatment with colony‐stimulating factor 1 receptor antagonists enables transient microglia depletion that ...
Maria Arbaizar‐Rovirosa, Jordi Pedragosa, Juan J Lozano, Carme Casal, Albert Pol, Mattia Gallizioli, Anna M Planas   +6 more
doaj   +1 more source

Human-induced pluripotent stem cell-derived microglia integrate into mouse retina and recapitulate features of endogenous microglia

eLife
Microglia exhibit both maladaptive and adaptive roles in the pathogenesis of neurodegenerative diseases and have emerged as a cellular target for central nervous system (CNS) disorders, including those affecting the retina.
Wenxin Ma, Lian Zhao, Biying Xu, Robert N Fariss, T Michael Redmond, Jizhong Zou, Wai T Wong, Wei Li   +7 more
doaj   +1 more source

The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo

Journal of Neuroinflammation, 2018
Background Microglia—the resident immune cells of the brain—are activated after brain lesions, e.g., cerebral ischemia, and polarize towards a classic “M1” pro-inflammatory or an alternative “M2” anti-inflammatory phenotype following characteristic ...
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Rebecca Rogall, Stefan Blaschke, Judith Kleinhaus, Noémie Reinert, Annika Bach, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger   +10 more
doaj   +1 more source

An updated assessment of microglia depletion: current concepts and future directions

Molecular Brain, 2017
Microglia are the principal resident immune cells in the central nervous system and are believed to be versatile players in both inflammatory and physiological contexts. On the one hand, in order to safeguard the microenvironment microglia can be rapidly
Jinming Han, Robert A. Harris, Xing-Mei Zhang   +2 more
doaj   +1 more source

Adaptive Müller cell responses to microglial activation mediate neuroprotection and coordinate inflammation in the retina

Journal of Neuroinflammation, 2011
Purpose Microglia and Müller cells are prominent participants in retinal responses to injury and disease that shape eventual tissue adaptation or damage.
Wang Minhua, Ma Wenxin, Zhao Lian, Fariss Robert N, Wong Wai T   +4 more
doaj   +1 more source