Results 31 to 40 of about 249,102 (311)

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease [PDF]

, 2009
The role of microglial cells in the pathogenesis of Alzheimer’s disease (AD) neurodegeneration is unknown. Although several works suggest that chronic neuroinflammation caused by activated microglia contributes to neurofibrillary degeneration, anti ...
Streit, Wolfgang J., Xue, Qing-Shan, Ingo Bechmann, Bechmann, Ingo, Braak, Heiko, Wolfgang J. Streit, Heiko Braak, Qing-Shan Xue   +7 more
core   +1 more source

Microglia replacement by bone marrow transplantation (Mr BMT) in the central nervous system of adult mice

STAR Protocols, 2021
Summary: Microglia are important immune cells in the central nervous system (CNS). Mutations in microglia may cause CNS disorders. Replacement of dysfunctional microglia with allogeneic wild-type microglia can correct the gene deficiency, thus treating ...
Zhen Xu, Xin Zhou, Bo Peng, Yanxia Rao
doaj   +1 more source

Microglia

Microbiology Spectrum, 2016
ABSTRACT The concept of the immunological privilege of the central nervous system (CNS) has had a profound influence on studies of interactions between the immune system and the CNS. At one time there was considerable debate as to whether there were any cells in the CNS of myeloid origin, but we now know that there are a number of populations
openaire   +4 more sources

A richer and more diverse future for microglia phenotypes

Heliyon, 2023
Microglia are the only resident innate immune cells derived from the mesoderm in the nerve tissue. They play a role in the development and maturation of the central nervous system (CNS).
Jie Wang, Wenbin He, Junlong Zhang
doaj   +1 more source

Aberrant NF-kappaB expression in autism spectrum condition : a mechanism for neuroinflammation [PDF]

, 2011
Autism spectrum condition (ASC) is recognized as having an inflammatory component. Post-mortem brain samples from patients with ASC display neuroglial activation and inflammatory markers in cerebrospinal fluid, although little is known about the ...
Young, Adam, Suckling, John, Sarah Lynch, Campbell, Elaine Catherine, Lynch, Sarah Janice, Elaine eCampbell, Powis, Simon J, Simon J. Powis, Adam eYoung, Sarah eLynch, Simon ePowis, Lynch, Sarah, Adam M. H. Young, Elaine Campbell, John Suckling, John eSuckling, Young, Adam M H, Powis, Simon John, Campbell, Elaine   +18 more
core   +2 more sources

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

Cell Reports, 2013
Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo ...
Isaac M. Chiu, Emiko T.A. Morimoto, Hani Goodarzi, Jennifer T. Liao, Sean O’Keeffe, Hemali P. Phatnani, Michael Muratet, Michael C. Carroll, Shawn Levy, Saeed Tavazoie, Richard M. Myers, Tom Maniatis   +11 more
doaj   +1 more source

Microglia-plaque dynamics measured in the hippocampus of p38^+/+ and p38^KO AD mice.

, 2023
(A) Left panels: Representative images of tissue sections probed for microglia (Iba1: TxRed [red]), fibrillar amyloid deposits (Thioflavin S: FITC [green]), and Aβ peptides (6E10: Cy5 [purple]) obtained on a Nikon confocal microscope.
Verda A. Davis (15999167), Hilaree N. Frazier (9092702), Meggie J. Coleman (15999170), Linda J. Van Eldik (7946330), David J. Braun (7107692), Colin B. Rogers (15999173)   +5 more
core   +1 more source

New insight on microglia activation in neurodegenerative diseases and therapeutics

Frontiers in Neuroscience, 2023
Microglia are immune cells within the central nervous system (CNS) closely linked to brain health and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
Yucong Xu, Yucong Xu, Wei Gao, Wei Gao, Yingnan Sun, Minghua Wu, Minghua Wu   +6 more
doaj   +1 more source

Advances in Visualizing Microglial Cells in Human Central Nervous System Tissue

Biomolecules, 2022
Neuroinflammation has recently been identified as a fundamentally important pathological process in most, if not all, CNS diseases. The main contributor to neuroinflammation is the microglia, which constitute the innate immune response system.
Christopher E. G. Uff, Karishma Patel, Charming Yeung, Ping K. Yip   +3 more
doaj   +1 more source

Microglia A Pictorial

Progress in Histochemistry and Cytochemistry, 1996
Progress in Histochemistry and Cytochemistry 31 (1996) XII,1-XIV,89. doi:10.1016/S0079-6336(96)80004-0 ; Received by publisher: 0000-01-01 ; Harvest Date: 2016-01-04 12:21:02 ; DOI:10.1016/S0079-6336(96)80004-0 ; Page Range: XII,1-XIV ...
Department of Neuroscience, University of Florida Brain Institute, Grainville, FL-32610 (USA) ( host institution ), Streit, W.J. ( author ), Graeber, M.B. ( author )   +2 more
openaire   +3 more sources