Results 51 to 60 of about 249,102 (311)

Aged lipid‐laden microglia display impaired responses to stroke [PDF]

, 2022
Microglial cells of the aged brain manifest signs of dysfunction that could contribute to the worse neurological outcome of stroke in the elderly. Treatment with colony‐stimulating factor 1 receptor antagonists enables transient microglia depletion that ...
Casal, Carme, Pol, Albert, Lozano Salvatella, Juan José, Anna M Planas, Jordi Pedragosa, Mattia Gallizioli, Juan J Lozano, Arbaizar Rovirosa, Maria, Pedragosa Ollé, Jordi, Casal, Carmen, Pol i Sorolla, Albert, Planas Obradors, Anna Maria, Gallizioli, Mattia, Arbaizar-Rovirosa, María, Maria Arbaizar‐Rovirosa, Carme Casal, Albert Pol, Pedragosa, Jordi, Lozano, Juan J., Planas, Anna M.   +19 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Microglia-like cells promote neuronal functions in cerebral organoids

, 2022
Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in vitro research window to the development of the cerebral cortex.
I Fagerlund (13377558), Š Lehtonen (11216805), P Korhonen (13377588), A Shakirzyanova (13377564), T Malm (13377591), M Koskuvi (11216772), Damian Hernandez (13066917), S Ohtonen (13377576), MF Fazaludeen (15839723), A Pebay (13377582), A Dougalis (13377561), H Konttinen (13377573), M Gómez-Budia (13377567), A Pelkonen (13377570), J Koistinaho (11216808), J Kuusisto (7684553), T Rauramaa (13377585)   +16 more
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

An updated assessment of microglia depletion: current concepts and future directions

Molecular Brain, 2017
Microglia are the principal resident immune cells in the central nervous system and are believed to be versatile players in both inflammatory and physiological contexts. On the one hand, in order to safeguard the microenvironment microglia can be rapidly
Jinming Han, Robert A. Harris, Xing-Mei Zhang   +2 more
doaj   +1 more source

What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior

Frontiers in Cellular Neuroscience, 2022
Microglia are dynamic cells, constantly surveying their surroundings and interacting with neurons and synapses. Indeed, a wealth of knowledge has revealed a critical role of microglia in modulating synaptic transmission and plasticity in the developing ...
Bernadette Basilico, Laura Ferrucci, Azka Khan, Silvia Di Angelantonio, Silvia Di Angelantonio, Davide Ragozzino, Davide Ragozzino, Ingrid Reverte, Ingrid Reverte   +8 more
doaj   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

In vitro models of microglia: a comparative study

Scientific Reports
Microglia perform key homeostatic functions to protect the central nervous system (CNS). However, in many brain disorders their protective functions are abrogated, contributing to disease progression.
Zoe Woolf, Taylor J. Stevenson, Kevin Lee, Blake Highet, Jena Macapagal Foliaki, Ramona Ratiu, Justin Rustenhoven, Jason Correia, Patrick Schweder, Peter Heppner, Maria Weinert, Natacha Coppieters, Thomas Park, Johanna Montgomery, Amy M. Smith, Michael Dragunow   +15 more
doaj   +1 more source

Rod microglia: a morphological definition. [PDF]

PLoS ONE, 2014
Brain microglial morphology relates to function, with ramified microglia surveying the micro-environment and amoeboid microglia engulfing debris. One subgroup of microglia, rod microglia, have been observed in a number of pathological conditions, however
Samuel E Taylor, Cristina Morganti-Kossmann, Jonathan Lifshitz, Jenna M Ziebell   +3 more
doaj   +1 more source

Neuron-Derived Extracellular Vesicles Modulate Microglia Activation and Function

Biology, 2021
Microglia act as the immune cells of the central nervous system (CNS). They play an important role in maintaining brain homeostasis but also in mediating neuroimmune responses to insult.
Hui Peng, Brock T. Harvey, Christopher I. Richards, Kimberly Nixon   +3 more
doaj   +1 more source