Results 51 to 60 of about 315,527 (297)

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. [PDF]

, 2019
Many risk genes for the development of Alzheimer's disease (AD) are exclusively or highly expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival.
Bollag, Gideon, Broome, Stephanie, Burton, Elizabeth A, Crapser, Joshua, Green, Kim N, Habets, Gaston, Hohsfield, Lindsay A, Ibrahim, Prabha, Lin, Jack, Nespi, Marika, Phan, Nicole Y, Rymar, Andrey, Severson, Paul L, Singh, Parmveer, Spangenberg, Elizabeth, Spevak, Wayne, Tsang, Garson, Walters, Jason, West, Brian L, Zhang, Chao, Zhang, Jiazhong, Zhang, Ying   +21 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Tools and Approaches for Studying Microglia In vivo

Frontiers in Immunology, 2020
Microglia are specialized resident macrophages of the central nervous system (CNS) that have important functions during neurodevelopment, homeostasis and disease.
Elisa Eme-Scolan, Elisa Eme-Scolan, Samantha J. Dando   +2 more
doaj   +1 more source

TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia [PDF]

, 2018
BACKGROUND: Mutations in the three-prime repair exonuclease 1 (TREX1) gene have been associated with neurological diseases, including Retinal Vasculopathy with Cerebral Leukoencephalopathy (RVCL).
Atkinson, John P, Bertram, Paula, Hajj-Ali, Rula, Jen, Joanna C, Kolar, Grant R, Kothari, Parul H, Schmidt, Robert E   +6 more
core   +3 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

In vitro models of microglia: a comparative study

Scientific Reports
Microglia perform key homeostatic functions to protect the central nervous system (CNS). However, in many brain disorders their protective functions are abrogated, contributing to disease progression.
Zoe Woolf, Taylor J. Stevenson, Kevin Lee, Blake Highet, Jena Macapagal Foliaki, Ramona Ratiu, Justin Rustenhoven, Jason Correia, Patrick Schweder, Peter Heppner, Maria Weinert, Natacha Coppieters, Thomas Park, Johanna Montgomery, Amy M. Smith, Michael Dragunow   +15 more
doaj   +1 more source

Rod microglia: a morphological definition. [PDF]

PLoS ONE, 2014
Brain microglial morphology relates to function, with ramified microglia surveying the micro-environment and amoeboid microglia engulfing debris. One subgroup of microglia, rod microglia, have been observed in a number of pathological conditions, however
Samuel E Taylor, Cristina Morganti-Kossmann, Jonathan Lifshitz, Jenna M Ziebell   +3 more
doaj   +1 more source

What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior

Frontiers in Cellular Neuroscience, 2022
Microglia are dynamic cells, constantly surveying their surroundings and interacting with neurons and synapses. Indeed, a wealth of knowledge has revealed a critical role of microglia in modulating synaptic transmission and plasticity in the developing ...
Bernadette Basilico, Laura Ferrucci, Azka Khan, Silvia Di Angelantonio, Silvia Di Angelantonio, Davide Ragozzino, Davide Ragozzino, Ingrid Reverte, Ingrid Reverte   +8 more
doaj   +1 more source

In vivo imaging reveals transient microglia recruitment and functional recovery of photoreceptor signaling after injury. [PDF]

, 2019
Microglia respond to damage and microenvironmental changes within the central nervous system by morphologically transforming and migrating to the lesion, but the real-time behavior of populations of these resident immune cells and the neurons they ...
Burns, Marie E, Ching, Karli, Miller, Eric B, Pugh, Edward N, Zhang, Pengfei   +4 more
core   +1 more source

Microglia shape presynaptic properties at developing glutamatergic synapses [PDF]

, 2019
Deficient neuron-microglia signaling during brain development is associated with abnormal synaptic maturation. However, the precise impact of deficient microglia function on synaptic maturation and the mechanisms involved remain poorly defined.
Arnoux, Bollinger, Cantaut-Belarif, Constantine-Paton, Conti, De Biase, Dobrunz, Doorn, Dumas, Durand, Durand, Gasparini, Gosselin, Grabert, Hellwig, Hessler, Hoshiko, Hsia, Isaac, Khazipov, Korber, Kullmann, Lam, Lavin, Limatola, Lowery, Maggi, Milior, Miyamoto, Mosser, Nimmerjahn, Pagani, Paolicelli, Paolicelli, Parkhurst, Pascual, Pfeiffer, Piccinin, Ragozzino, Renger, Reshef, Reshef, Ricci-Tersenghi, Sallert, Santello, Schafer, Schecter, Sellner, Semple, Singh, Stevens, Tian, Tremblay, Tremblay, Voronin, Wake, Wasling, Weinhard, Winkler, Wolf, Yoon, Zhan   +61 more
core   +1 more source