Results 61 to 70 of about 249,102 (311)

Microglia in neurodegeneration

Nature Neuroscience, 2018
The neuroimmune system is involved in development, normal functioning, aging, and injury of the central nervous system. Microglia, first described a century ago, are the main neuroimmune cells and have three essential functions: a sentinel function involved in constant sensing of changes in their environment, a housekeeping function that promotes ...
Suzanne Hickman, Saef Izzy, Pritha Sen, Liza Morsett, Joseph El Khoury   +4 more
openaire   +3 more sources

Stimulation of Na⁺/H⁺ Exchanger Isoform 1 Promotes Microglial Migration [PDF]

, 2013
Regulation of microglial migration is not well understood. In this study, we proposed that Na+/H+ exchanger isoform 1 (NHE-1) is important in microglial migration.
Cengiz, P, Yuan Hui, Baba, Akemichi, Vishal Chanana, Chanana, V, Dong Kim (443919), Shi Yejie, Sun Dandan, Dandan Sun, Zhang, Zhe, Hui Yuan, Sun, Dandan, Toshio Matsuda, Yejie Shi, Akemichi Baba, An Sun, Matsuda Toshio, Peter Ferrazzano, Matsuda, Toshio, Pelin Cengiz, Akemichi Baba (253010), Baba, A, Shi, Y, Ferrazzano, Peter, Ferrazzano Peter, Hui Yuan (402180), Kim, Dong, Dong Kim, Sun, D, Vishal Chanana (448559), Shi, Yejie, Cengiz, Pelin, Toshio Matsuda (448560), Ferrazzano, P, Matsuda, T, Yuan, H, Peter Ferrazzano (448562), Dandan Sun (448563), Kim, D, Chanana, Vishal, Baba Akemichi, Pelin Cengiz (448561), Cengiz Pelin, Yuan, Hui, Yejie Shi (448558), Kim Dong, Chanana Vishal   +46 more
core   +2 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration

Frontiers in Neuroanatomy, 2017
Microglia activation is recognized as the hallmark of neuroinflammation. However, the activation profile and phenotype changes of microglia during the process of retinal degeneration are poorly understood.
Tian Zhou, Zijing Huang, Xiaowei Sun, Xiaowei Zhu, Lingli Zhou, Mei Li, Bing Cheng, Xialin Liu, Chang He   +8 more
doaj   +1 more source

Tools and Approaches for Studying Microglia In vivo

Frontiers in Immunology, 2020
Microglia are specialized resident macrophages of the central nervous system (CNS) that have important functions during neurodevelopment, homeostasis and disease.
Elisa Eme-Scolan, Elisa Eme-Scolan, Samantha J. Dando   +2 more
doaj   +1 more source

Microglia-Derived Microvesicles Affect Microglia Phenotype in Glioma [PDF]

Frontiers in Cellular Neuroscience, 2019
Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic acids. In the nervous system, EVs participate to neuron-glial cross-talk, a bidirectional communication important to ...
Alfonso Grimaldi, Carmela Serpe, Giuseppina Chece, Valentina Nigro, Angelo Sarra, Barbara Ruzicka, Michela Relucenti, Giuseppe Familiari, Giancarlo Ruocco, Giuseppe Rubens Pascucci, Francesca Guerrieri, Cristina Limatola, Cristina Limatola, Myriam Catalano, Myriam Catalano   +14 more
openaire   +5 more sources

Microglia and Alzheimer’s Disease

International Journal of Molecular Sciences, 2022
There is a huge need for novel therapeutic and preventative approaches to Alzheimer’s disease (AD) and neuroinflammation seems to be one of the most fascinating solutions. The primary cell type that performs immunosurveillance and helps clear out unwanted chemicals from the brain is the microglia.
Merighi, Stefania, Nigro, Manuela, Travagli, Alessia, Gessi, Stefania   +3 more
openaire   +2 more sources

Modulation and function of microglial phenotypes [PDF]

, 2012
Microglia are the sentinel cells of the retina, where they are involved in surveillance of tissue integrity and clearance of cellular debris. The innate immune functions of microglia are tightly controlled by retinal neurons via the secretion of ...
Karlstetter, Marcus
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals

eLife
Microglia are brain-resident macrophages playing pivotal roles in central nervous system (CNS) development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance remains largely unknown.
Yi Wu, Weilin Guo, Haoyue Kuang, Xiaohai Wu, Thi Huong Trinh, Yuexin Wang, Shizheng Zhao, Zilong Wen, Tao Yu   +8 more
doaj   +1 more source