Results 61 to 70 of about 235,228 (311)

What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior

Frontiers in Cellular Neuroscience, 2022
Microglia are dynamic cells, constantly surveying their surroundings and interacting with neurons and synapses. Indeed, a wealth of knowledge has revealed a critical role of microglia in modulating synaptic transmission and plasticity in the developing ...
Bernadette Basilico, Laura Ferrucci, Azka Khan, Silvia Di Angelantonio, Silvia Di Angelantonio, Davide Ragozzino, Davide Ragozzino, Ingrid Reverte, Ingrid Reverte   +8 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Differences in microglia morphological profiles reflect divergent emotional temperaments: insights from a selective breeding model

Translational Psychiatry, 2022
Microglia play critical roles in healthy brain development and function, as well as the neuropathology underlying a range of brain diseases. Despite evidence for a role of microglia in affective regulation and mood disorders, little is known regarding ...
Pamela M. Maras, Elaine K. Hebda-Bauer, Megan H. Hagenauer, Kathryn L. Hilde, Peter Blandino, Stanley J. Watson, Huda Akil   +6 more
doaj   +1 more source

Microglia in neurodegeneration

Nature Neuroscience, 2018
The neuroimmune system is involved in development, normal functioning, aging, and injury of the central nervous system. Microglia, first described a century ago, are the main neuroimmune cells and have three essential functions: a sentinel function involved in constant sensing of changes in their environment, a housekeeping function that promotes ...
Suzanne Hickman, Saef Izzy, Pritha Sen, Liza Morsett, Joseph El Khoury   +4 more
openaire   +3 more sources

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Microglia mechanics : immune activation alters traction forces and durotaxis

, 2015
This work was supported by the Austrian Agency for International Cooperation in Education and Research (Scholarship to LB), Faculty of Computer Science and Biomedical Engineering at Graz University of Technology (Scholarship to LB), German National ...
Gather, M., Bollmann, Lars, Gather, Malte Christian, Kristian Franze, Gautier, H., Gerhard A. Holzapfel, Lars eBollmann, Giuliano Scarcelli, Shahapure, Rajesh, Malte C. Gather, Ulbricht, E., Rajesh Shahapure, Holzapfel, G., Gautier, Hélène O. B., Rajesh eShahapure, Bollmann, L., Franze, K., Elke eUlbricht, Scarcelli, Giuliano, Lars Bollmann, Scarcelli, G., Koser, David E., Ulbricht, Elke, David Elias Koser, Koser, D., David E. Koser, Kristian eFranze, Holzapfel, Gerhard A., Elke Ulbricht, Giuliano eScarcelli, Shahapure, R., Hélène O. B. Gautier, Franze, Kristian   +32 more
core   +2 more sources

Additional file 4 of A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus

, 2021
Additional file 4: Fig. 4. Neuronal and glial marker expressions in primary cell cultures. PCR analysis for NeuN, GFAP, and Iba-1 in primary cultures of Neuron, Astrocyte, and Microglia (A)
Akira Hirasawa (445958), Shinji Yamamoto (458280), Kensuke Iwasa (11880702), Nan Yagishita-kyo (11880708), Yoshinori Takei (302218), Kota Yamashina (11880705), Keisuke Yoshikawa (11880711), Takeo Awaji (3619961), Kei Maruyama (203085)   +8 more
core   +1 more source

In vitro models of microglia: a comparative study

Scientific Reports
Microglia perform key homeostatic functions to protect the central nervous system (CNS). However, in many brain disorders their protective functions are abrogated, contributing to disease progression.
Zoe Woolf, Taylor J. Stevenson, Kevin Lee, Blake Highet, Jena Macapagal Foliaki, Ramona Ratiu, Justin Rustenhoven, Jason Correia, Patrick Schweder, Peter Heppner, Maria Weinert, Natacha Coppieters, Thomas Park, Johanna Montgomery, Amy M. Smith, Michael Dragunow   +15 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Aberrant NF-kappaB expression in autism spectrum condition : a mechanism for neuroinflammation

, 2011
Autism spectrum condition (ASC) is recognized as having an inflammatory component. Post-mortem brain samples from patients with ASC display neuroglial activation and inflammatory markers in cerebrospinal fluid, although little is known about the ...
Young, Adam, Suckling, John, Sarah Lynch, Campbell, Elaine Catherine, Lynch, Sarah Janice, Elaine eCampbell, Powis, Simon J, Simon J. Powis, Adam eYoung, Sarah eLynch, Simon ePowis, Lynch, Sarah, Adam M. H. Young, Elaine Campbell, John Suckling, John eSuckling, Young, Adam M H, Powis, Simon John, Campbell, Elaine   +18 more
core   +2 more sources