Results 41 to 50 of about 203,390 (263)

An updated assessment of microglia depletion: current concepts and future directions

Molecular Brain, 2017
Microglia are the principal resident immune cells in the central nervous system and are believed to be versatile players in both inflammatory and physiological contexts. On the one hand, in order to safeguard the microenvironment microglia can be rapidly
Jinming Han, Robert A. Harris, Xing-Mei Zhang   +2 more
doaj   +1 more source

Rod microglia: a morphological definition. [PDF]

PLoS ONE, 2014
Brain microglial morphology relates to function, with ramified microglia surveying the micro-environment and amoeboid microglia engulfing debris. One subgroup of microglia, rod microglia, have been observed in a number of pathological conditions, however
Samuel E Taylor, Cristina Morganti-Kossmann, Jonathan Lifshitz, Jenna M Ziebell   +3 more
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Differences in microglia morphological profiles reflect divergent emotional temperaments: insights from a selective breeding model

Translational Psychiatry, 2022
Microglia play critical roles in healthy brain development and function, as well as the neuropathology underlying a range of brain diseases. Despite evidence for a role of microglia in affective regulation and mood disorders, little is known regarding ...
Pamela M. Maras, Elaine K. Hebda-Bauer, Megan H. Hagenauer, Kathryn L. Hilde, Peter Blandino, Stanley J. Watson, Huda Akil   +6 more
doaj   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Microglia-Derived Microvesicles Affect Microglia Phenotype in Glioma [PDF]

Frontiers in Cellular Neuroscience, 2019
Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic acids. In the nervous system, EVs participate to neuron-glial cross-talk, a bidirectional communication important to ...
Alfonso Grimaldi, Carmela Serpe, Giuseppina Chece, Valentina Nigro, Angelo Sarra, Barbara Ruzicka, Michela Relucenti, Giuseppe Familiari, Giancarlo Ruocco, Giuseppe Rubens Pascucci, Francesca Guerrieri, Cristina Limatola, Cristina Limatola, Myriam Catalano, Myriam Catalano   +14 more
openaire   +5 more sources

Microglia and Alzheimer’s Disease

International Journal of Molecular Sciences, 2022
There is a huge need for novel therapeutic and preventative approaches to Alzheimer’s disease (AD) and neuroinflammation seems to be one of the most fascinating solutions. The primary cell type that performs immunosurveillance and helps clear out unwanted chemicals from the brain is the microglia.
Merighi, Stefania, Nigro, Manuela, Travagli, Alessia, Gessi, Stefania   +3 more
openaire   +2 more sources

Microglia in the aging brain: relevance to neurodegeneration

Molecular Neurodegeneration, 2010
Microglia cells are the brain counterpart of macrophages and function as the first defense in the brain. Although they are neuroprotective in the young brain, microglia cells may be primed to react abnormally to stimuli in the aged brain and to become ...
Ding Jian-Qing, Luo Xiao-Guang, Chen Sheng-Di   +2 more
doaj   +1 more source

What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior

Frontiers in Cellular Neuroscience, 2022
Microglia are dynamic cells, constantly surveying their surroundings and interacting with neurons and synapses. Indeed, a wealth of knowledge has revealed a critical role of microglia in modulating synaptic transmission and plasticity in the developing ...
Bernadette Basilico, Laura Ferrucci, Azka Khan, Silvia Di Angelantonio, Silvia Di Angelantonio, Davide Ragozzino, Davide Ragozzino, Ingrid Reverte, Ingrid Reverte   +8 more
doaj   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source