Results 41 to 50 of about 249,102 (311)

Identifying a Csmd3⁺ Microglial Subpopulation that Drives Cold-to-Hot Transition and Immune-Cure in Glioblastoma. [PDF]

Adv Sci (Weinh)
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Jiang HF, Gao PP, Du YW, Wu LQ, Yin EZ, An Q, Ding ZH, Shi JW, Shu Y, Chen R, Liu F, Li M, Chen XQ.   +12 more
europepmc   +2 more sources

Microglia replacement by microglia transplantation (Mr MT) in the adult mouse brain

STAR Protocols, 2021
Summary: Mutations in microglia may cause brain disorders. Replacement of dysfunctional microglia by allogeneic wild-type microglia from bone marrow transplantation (Mr BMT) or peripheral blood can correct the gene deficiency at the brain-wide scale but ...
Zhen Xu, Bo Peng, Yanxia Rao
doaj   +1 more source

Regulation of microglial cell function by corticosteroids and disruption by organotins [PDF]

, 2014
Microglia cells are the resident brain macrophages regulating in the initiation and maintenance of neuroinflammation. Chronic or exacerbated activation of microglia can contribute to neurodegenerative diseases.
Chantong, Boonrat
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Microglia from neurogenic and non-neurogenic regions display differential proliferative potential and neuroblast support

Frontiers in Cellular Neuroscience, 2014
Microglia isolated from the neurogenic subependymal zone (SEZ) and hippocampus (HC) are capable of massive in vitro population expansion that is not possible with microglia isolated from non-neurogenic regions.
Gregory Paul Marshall, Loic P Deleyrolle, Brent A Reynolds, Dennis A Steindler, Eric D Laywell   +4 more
doaj   +1 more source

Death by microglia [PDF]

Journal of Experimental Medicine, 2019
The roles of microglia and ApoE in tauopathies, such as Alzheimer’s disease, remain elusive. In this issue, Shi et al. (https://doi.org/10.1084/jem.20190980) demonstrate that microglia-mediated innate immunity collaborates with ApoE to drive neurodegeneration and disease progression in a mouse model of tauopathy.
Shahrnaz Kemal, Robert Vassar
openaire   +2 more sources

Imaging Microglial/Macrophage Activation in Spinal Cords of Experimental Autoimmune Encephalomyelitis Rats by Positron Emission Tomography Using the Mitochondrial 18kDa Translocator Protein Radioligand [18F]DPA-714 [PDF]

, 2012
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Activated microglia/macrophages play a key role in the immunopathogenesis of MS and its corresponding animal models, experimental autoimmune encephalomyelitis (EAE).
Thézé, Benoit, Dollé, Frédéric, Brulon, Vincent, Fontyn, Yoann, Abourbeh, Galith, Dubois, Albertine, Tavitian, Bertrand, Boisgard, Raphael, Maroy, Renaud   +8 more
core   +1 more source

Microglial process dynamics depend on astrocyte and synaptic activity [PDF]

, 2023
Microglial processes survey the brain parenchyma, but it is unknown whether this process is influenced by the cell activity of nearby microglia under physiological conditions.
Ikegami, Ako, Kato, Daisuke, Wake, Hiroaki   +2 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Progressive retinal degeneration and glial activation in the Cln6nclf mouse model of neuronal ceroid lipofuscinosis : a beneficial effect of DHA and Curcumin supplementation [PDF]

, 2013
Neuronal ceroid lipofuscinosis (NCL) is a group of neurodegenerative lysosomal storage disorders characterized by vision loss, mental and motor deficits, and spontaneous seizures.
Monica Langiu, Myriam Mirza, Langiu, Monica, Tamm, Ernst R., Mirza, Myriam, Langmann, Thomas, Ernst R. Tamm, Aleksandra Somogyi, Marcus Karlstetter, Mika O. Ruonala, Volz, Cornelia, Jägle, Herbert, Herbert Jägle, Ernst R Tamm, Somogyi, Aleksandra, Cornelia Volz, Thomas Langmann, Mika O Ruonala, Karlstetter, Marcus, Ruonala, Mika O.   +19 more
core   +2 more sources