Results 21 to 30 of about 249,102 (311)

Microglia and Microglia-Like Cells: Similar but Different [PDF]

Frontiers in Cellular Neuroscience, 2022
Microglia are the tissue-resident macrophages of the central nervous parenchyma. In mammals, microglia are thought to originate from yolk sac precursors and posteriorly maintained through the entire life of the organism. However, the contribution of microglial cells from other sources should also be considered.
Cuadros Ojeda, Miguel Ángel, Sepúlveda Justo, María Del Rosario, Martín Oliva, Francisco David, Marín Teva, José Luis, Neubrand, Veronika Elisabeth   +4 more
openaire   +4 more sources

Microglial K(+) channel expression in young adult and aged mice. [PDF]

, 2015
The K(+) channel expression pattern of microglia strongly depends on the cells' microenvironment and has been recognized as a sensitive marker of the cells' functional state. While numerous studies have been performed on microglia in vitro, our knowledge
Tom Schilling, Schilling, T, Eder, C, Claudia Eder   +3 more
core   +1 more source

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]

, 2012
BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Nicole Berchtold, Hrabovszky, Erik, Liposits, Zsolt, Erik Hrabovszky, Norbert Solymosi, Berchtold, Nicole, Imre Kalló, Carl Cotman, Solymosi, Norbert, István Likó, Cotman, Carl, Zsolt Liposits, Likó, István, Sárvári, Miklós, Miklós Sárvári, Kalló, Imre   +15 more
core   +3 more sources

Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia

Cell Reports, 2019
Summary: Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity. However, the signaling pathways and environmental cues that drive diverse states of microglia are incompletely ...
Sarah R. Anderson, Jacqueline M. Roberts, Jianmin Zhang, Michael R. Steele, Cesar O. Romero, Alejandra Bosco, Monica L. Vetter   +6 more
doaj   +1 more source

Comparing the Characteristics of Microglia Preparations Generated Using Different Human iPSC-Based Differentiation Methods to Model Neurodegenerative Diseases

ASN Neuro, 2022
As the resident immune cells of the healthy nervous system, homeostatic microglia can rapidly become activated in response to injury/disease. Dysregulated microglia activation is a hallmark of nervous system disorders including neurodegenerative diseases
Ye Man Tang, Nisha S. Pulimood, Stefano Stifani   +2 more
doaj   +1 more source

Microglia mechanics : immune activation alters traction forces and durotaxis [PDF]

, 2015
This work was supported by the Austrian Agency for International Cooperation in Education and Research (Scholarship to LB), Faculty of Computer Science and Biomedical Engineering at Graz University of Technology (Scholarship to LB), German National ...
Gather, M., Bollmann, Lars, Gather, Malte Christian, Kristian Franze, Gautier, H., Gerhard A. Holzapfel, Lars eBollmann, Giuliano Scarcelli, Shahapure, Rajesh, Malte C. Gather, Ulbricht, E., Rajesh Shahapure, Holzapfel, G., Gautier, Hélène O. B., Rajesh eShahapure, Bollmann, L., Franze, K., Elke eUlbricht, Scarcelli, Giuliano, Lars Bollmann, Scarcelli, G., Koser, David E., Ulbricht, Elke, David Elias Koser, Koser, D., David E. Koser, Kristian eFranze, Holzapfel, Gerhard A., Elke Ulbricht, Giuliano eScarcelli, Shahapure, R., Hélène O. B. Gautier, Franze, Kristian   +32 more
core   +2 more sources

Long term impact of systemic bacterial infection on the cerebral vasculature and microglia [PDF]

, 2012
Background: Systemic infection leads to generation of inflammatory mediators that result in metabolic and behavioural changes. Repeated or chronic systemic inflammation leads to a state of innate immune tolerance: a protective mechanism against over ...
Perry, V. Hugh, Püntener Ursula, Perry V, Steven G Booth, Teeling, Jessica L., Booth Steven G, V Hugh Perry, Ursula Püntener, Teeling Jessica L, Jessica L Teeling, Puentener, U., Booth, S.   +11 more
core   +3 more sources

Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia

Mediators of Inflammation, 2017
Microglia play an important role in mediating inflammatory processes in the central nervous system (CNS). Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor and could decrease neuropathology in Alzheimer’s disease ...
Xiaobao Zhang, Fang Yan, Jizheng Cui, Yong Wu, Hengfei Luan, Miaomiao Yin, Zhibin Zhao, Jiying Feng, Jinwei Zhang   +8 more
doaj   +1 more source

The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function

Journal of Neuroinflammation, 2020
Background Microglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia polarize towards different phenotypes.
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Helena Monière, Igor Jakovcevski, Pavle Andjus, Dunja Bijelic, Stefan Blaschke, Helene Luise Walter, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger   +11 more
doaj   +1 more source

Microglia actively regulate the number of functional synapses. [PDF]

PLoS ONE, 2013
Microglia are the immunocompetent cells of the central nervous system. In the physiological setting, their highly motile processes continually survey the local brain parenchyma and transiently contact synaptic elements.
Kyungmin Ji, Gulcan Akgul, Lonnie P Wollmuth, Stella E Tsirka   +3 more
doaj   +1 more source