Results 21 to 30 of about 193,226 (120)

Microglia from neurogenic and non-neurogenic regions display differential proliferative potential and neuroblast support

Frontiers in Cellular Neuroscience, 2014
Microglia isolated from the neurogenic subependymal zone (SEZ) and hippocampus (HC) are capable of massive in vitro population expansion that is not possible with microglia isolated from non-neurogenic regions.
Gregory Paul Marshall, Loic P Deleyrolle, Brent A Reynolds, Dennis A Steindler, Eric D Laywell   +4 more
doaj   +1 more source

Neuron-Derived Extracellular Vesicles Modulate Microglia Activation and Function

Biology, 2021
Microglia act as the immune cells of the central nervous system (CNS). They play an important role in maintaining brain homeostasis but also in mediating neuroimmune responses to insult.
Hui Peng, Brock T. Harvey, Christopher I. Richards, Kimberly Nixon   +3 more
doaj   +1 more source

Microglia replacement by microglia transplantation (Mr MT) in the adult mouse brain

STAR Protocols, 2021
Summary: Mutations in microglia may cause brain disorders. Replacement of dysfunctional microglia by allogeneic wild-type microglia from bone marrow transplantation (Mr BMT) or peripheral blood can correct the gene deficiency at the brain-wide scale but ...
Zhen Xu, Bo Peng, Yanxia Rao
doaj   +1 more source

Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration

Frontiers in Neuroanatomy, 2017
Microglia activation is recognized as the hallmark of neuroinflammation. However, the activation profile and phenotype changes of microglia during the process of retinal degeneration are poorly understood.
Tian Zhou, Zijing Huang, Xiaowei Sun, Xiaowei Zhu, Lingli Zhou, Mei Li, Bing Cheng, Xialin Liu, Chang He   +8 more
doaj   +1 more source

What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior

Frontiers in Cellular Neuroscience, 2022
Microglia are dynamic cells, constantly surveying their surroundings and interacting with neurons and synapses. Indeed, a wealth of knowledge has revealed a critical role of microglia in modulating synaptic transmission and plasticity in the developing ...
Bernadette Basilico, Laura Ferrucci, Azka Khan, Silvia Di Angelantonio, Silvia Di Angelantonio, Davide Ragozzino, Davide Ragozzino, Ingrid Reverte, Ingrid Reverte   +8 more
doaj   +1 more source

Differences in microglia morphological profiles reflect divergent emotional temperaments: insights from a selective breeding model

Translational Psychiatry, 2022
Microglia play critical roles in healthy brain development and function, as well as the neuropathology underlying a range of brain diseases. Despite evidence for a role of microglia in affective regulation and mood disorders, little is known regarding ...
Pamela M. Maras, Elaine K. Hebda-Bauer, Megan H. Hagenauer, Kathryn L. Hilde, Peter Blandino, Stanley J. Watson, Huda Akil   +6 more
doaj   +1 more source

In vitro models of microglia: a comparative study

Scientific Reports
Microglia perform key homeostatic functions to protect the central nervous system (CNS). However, in many brain disorders their protective functions are abrogated, contributing to disease progression.
Zoe Woolf, Taylor J. Stevenson, Kevin Lee, Blake Highet, Jena Macapagal Foliaki, Ramona Ratiu, Justin Rustenhoven, Jason Correia, Patrick Schweder, Peter Heppner, Maria Weinert, Natacha Coppieters, Thomas Park, Johanna Montgomery, Amy M. Smith, Michael Dragunow   +15 more
doaj   +1 more source

Characterizing newly repopulated microglia in the adult mouse: impacts on animal behavior, cell morphology, and neuroinflammation.

PLoS ONE, 2015
Microglia are the primary immune cell in the brain and are postulated to play important roles outside of immunity. Administration of the dual colony-stimulating factor 1 receptor (CSF1R)/c-Kit kinase inhibitor, PLX3397, to adult mice results in the ...
Monica R P Elmore, Rafael J Lee, Brian L West, Kim N Green   +3 more
doaj   +1 more source

Microglia in the aging brain: relevance to neurodegeneration

Molecular Neurodegeneration, 2010
Microglia cells are the brain counterpart of macrophages and function as the first defense in the brain. Although they are neuroprotective in the young brain, microglia cells may be primed to react abnormally to stimuli in the aged brain and to become ...
Ding Jian-Qing, Luo Xiao-Guang, Chen Sheng-Di   +2 more
doaj   +1 more source

Tools and Approaches for Studying Microglia In vivo

Frontiers in Immunology, 2020
Microglia are specialized resident macrophages of the central nervous system (CNS) that have important functions during neurodevelopment, homeostasis and disease.
Elisa Eme-Scolan, Elisa Eme-Scolan, Samantha J. Dando   +2 more
doaj   +1 more source