Results 21 to 30 of about 203,390 (263)
Journal of Neuroinflammation, 2020 Background Microglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia polarize towards different phenotypes.
Sabine Ulrike Vay +11 more
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New insight on microglia activation in neurodegenerative diseases and therapeutics
Frontiers in Neuroscience, 2023 Microglia are immune cells within the central nervous system (CNS) closely linked to brain health and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
Yucong Xu +6 more
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Mediators of Inflammation, 2017 Microglia play an important role in mediating inflammatory processes in the central nervous system (CNS). Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor and could decrease neuropathology in Alzheimer’s disease ...
Xiaobao Zhang +8 more
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Advances in Visualizing Microglial Cells in Human Central Nervous System Tissue
Biomolecules, 2022 Neuroinflammation has recently been identified as a fundamentally important pathological process in most, if not all, CNS diseases. The main contributor to neuroinflammation is the microglia, which constitute the innate immune response system.
Christopher E. G. Uff +3 more
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Microbiology Spectrum, 2016 ABSTRACT The concept of the immunological privilege of the central nervous system (CNS) has had a profound influence on studies of interactions between the immune system and the CNS. At one time there was considerable debate as to whether there were any cells in the CNS of myeloid origin, but we now know that there are a number of populations
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Cell Reports, 2013 Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo ...
Isaac M. Chiu +11 more
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STAR Protocols, 2021 Summary: Microglia are important immune cells in the central nervous system (CNS). Mutations in microglia may cause CNS disorders. Replacement of dysfunctional microglia with allogeneic wild-type microglia can correct the gene deficiency, thus treating ...
Zhen Xu, Xin Zhou, Bo Peng, Yanxia Rao
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A richer and more diverse future for microglia phenotypes
Heliyon, 2023 Microglia are the only resident innate immune cells derived from the mesoderm in the nerve tissue. They play a role in the development and maturation of the central nervous system (CNS).
Jie Wang, Wenbin He, Junlong Zhang
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Progress in Histochemistry and Cytochemistry, 1996 Progress in Histochemistry and Cytochemistry 31 (1996) XII,1-XIV,89. doi:10.1016/S0079-6336(96)80004-0 ; Received by publisher: 0000-01-01 ; Harvest Date: 2016-01-04 12:21:02 ; DOI:10.1016/S0079-6336(96)80004-0 ; Page Range: XII,1-XIV ...
Department of Neuroscience, University of Florida Brain Institute, Grainville, FL-32610 (USA) ( host institution ) +2 more
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Frontiers in Cellular Neuroscience, 2014 Microglia isolated from the neurogenic subependymal zone (SEZ) and hippocampus (HC) are capable of massive in vitro population expansion that is not possible with microglia isolated from non-neurogenic regions.
Gregory Paul Marshall +4 more
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