Results 21 to 30 of about 315,527 (297)

Microglia actively regulate the number of functional synapses. [PDF]

PLoS ONE, 2013
Microglia are the immunocompetent cells of the central nervous system. In the physiological setting, their highly motile processes continually survey the local brain parenchyma and transiently contact synaptic elements.
Kyungmin Ji, Gulcan Akgul, Lonnie P Wollmuth, Stella E Tsirka   +3 more
doaj   +1 more source

Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia

Mediators of Inflammation, 2017
Microglia play an important role in mediating inflammatory processes in the central nervous system (CNS). Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor and could decrease neuropathology in Alzheimer’s disease ...
Xiaobao Zhang, Fang Yan, Jizheng Cui, Yong Wu, Hengfei Luan, Miaomiao Yin, Zhibin Zhao, Jiying Feng, Jinwei Zhang   +8 more
doaj   +1 more source

The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function

Journal of Neuroinflammation, 2020
Background Microglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia polarize towards different phenotypes.
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Helena Monière, Igor Jakovcevski, Pavle Andjus, Dunja Bijelic, Stefan Blaschke, Helene Luise Walter, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger   +11 more
doaj   +1 more source

CXCL16/CXCR6 axis drives microglia/macrophages phenotype in physiological conditions and plays a crucial role in glioma [PDF]

, 2018
Microglia are patrolling cells that sense changes in the brain microenvironment and respond acquiring distinct phenotypes that can be either beneficial or detrimental for brain homeostasis.
Antonangeli, Fabrizio, D'Alessandro, Giuseppina, Esposito, Vincenzo, Lepore, Francesca, Limatola, Cristina, Santoro, Antonio, Trettel, Flavia   +6 more
core   +1 more source

Microglia

Microbiology Spectrum, 2016
ABSTRACT The concept of the immunological privilege of the central nervous system (CNS) has had a profound influence on studies of interactions between the immune system and the CNS. At one time there was considerable debate as to whether there were any cells in the CNS of myeloid origin, but we now know that there are a number of populations
openaire   +4 more sources

Diverse Inflammatory Response After Cerebral Microbleeds Includes Coordinated Microglial Migration and Proliferation. [PDF]

, 2018
BACKGROUND AND PURPOSE:Cerebral microbleeds are linked to cognitive decline, but it remains unclear how they impair neuronal function. Infarction is not typically observed near microbleeds, suggesting more subtle mechanisms, such as inflammation, may ...
Ahn, Sung Ji, Anrather, Josef, Nishimura, Nozomi, Schaffer, Chris B   +3 more
core   +1 more source

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model [PDF]

, 2020
Alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia are characterized by neuronal expression of aberrant tau protein, tau hyperphosphorylation (pTAU), tau aggregation and neurofibrillary tangle formation sequentially ...
Carmans, Sofie, de Vries, Helga E., Franssen, Marc, Kamermans, Alwin, Popovic, Marko, Roucourt, Bart, Schouten, Marijn, Sobrino, Tomás, van der Pol, Susanne M.A., van Olst, Lynn, Vandenbroucke, Roosmarijn, Verhaege, Daan, Wever, Dennis, Ytebrouck, Ellen   +13 more
core   +1 more source

Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. [PDF]

, 2018
ObjectiveInhibitors of the voltage-gated K+ channel Kv1.3 are currently in development as immunomodulators for the treatment of autoimmune diseases. As Kv1.3 is also expressed on microglia and has been shown to be specifically up-regulated on "M1-like ...
Azam, Beeton, Beschorner, Campanella, Chen, Chen, Chen, Courties, DeCoursey, Duque, Fadool, Fordyce, Fu, Gazula, Hu, Iadecola, Jacobs, Jin, Kaushal, Kawabori, Kettenmann, Khanna, Kundu-Raychaudhuri, Longa, Lyons, Macrez, Maezawa, Maezawa, Matheu, Meisel, Murray, Nguyen, Noraberg, Pannasch, Peng, Pennington, Pereira, Price, Rangaraju, Rangaraju, Rus, Ryck, Schlattmann, Schlichter, Schmitz, Tarcha, Tarcha, Wang, Wulff, Wulff   +49 more
core   +2 more sources

New insight on microglia activation in neurodegenerative diseases and therapeutics

Frontiers in Neuroscience, 2023
Microglia are immune cells within the central nervous system (CNS) closely linked to brain health and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
Yucong Xu, Yucong Xu, Wei Gao, Wei Gao, Yingnan Sun, Minghua Wu, Minghua Wu   +6 more
doaj   +1 more source

Stimulation of Na⁺/H⁺ Exchanger Isoform 1 Promotes Microglial Migration [PDF]

, 2013
Regulation of microglial migration is not well understood. In this study, we proposed that Na+/H+ exchanger isoform 1 (NHE-1) is important in microglial migration.
A Bretscher, A Hall, Akemichi Baba, AM Woodward, B Hinz, B Masereel, C Frantz, C Martin, C Nolte, C Stock, CH Choi, Dandan Sun, DB Kintner, Dong Kim, GG Borisy, GW Kreutzberg, H Chen, H Kettenmann, HS Kim, Hui Yuan, J Luo, J Luo, K Nakamura, K Takeuchi, KP Yip, L Cartier, L Walter, L Yu, M Ghosh, M Ifuku, M Noda, M Noda, M Schliwa, MF Carlier, N Takayama, N Yonezawa, Pelin Cengiz, Peter Ferrazzano, PK Tucker, S Honda, SP Denker, SP Denker, T Matsuda, T Matsui, TM Gomez, Toshio Matsuda, Vishal Chanana, Y Liu, Y Shi, Yejie Shi, Zhe Zhang   +50 more
core   +9 more sources