Results 271 to 280 of about 388,044 (340)

Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils. [PDF]

Alzheimers Res Ther
Etani H, Takatori S, Wang W, Omi J, Amiya Y, Akahori A, Watanabe H, Sonn I, Okano H, Hara N, Hasegawa M, Miyashita A, Kikuchi M, Ikeuchi T, Morishima M, Saito Y, Murayama S, Saito T, Saido TC, Takai T, Ohwada T, Aoki J, Tomita T.   +22 more
europepmc   +1 more source

Characterization of the nature and consequence of the microglia response to high fat diet

, 2016
Caroline Baufeld
openalex   +2 more sources

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, EarlyView.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source

Gut dysbiosis leads to cognitive decline through CNTF-mediated activation of microglia in mice. [PDF]

BMC Biol
Krishnapriya, Rishikesh, Kishanchand DK, Haack I, Hosseini S, Deepti A, Sudhadevi T, Michaelsen-Preusse K, Sivan U, Korte M, Sasidharan BCP.   +10 more
europepmc   +1 more source

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Lymphoid gene expression supports neuroprotective microglia function. [PDF]

Nature
Ayata P, Crowley JM, Challman MF, Sahasrabuddhe V, Gratuze M, Werneburg S, Ribeiro D, Hays EC, Durán-Laforet V, Faust TE, Hwang P, Mendes Lopes F, Nikopoulou C, Buchholz S, Murphy RE, Mei T, Pimenova AA, Romero-Molina C, Garretti F, Patel TA, De Sanctis C, Ramirez Jimenez AV, Crow M, Weiss FD, Ulrich JD, Marcora E, Murray JW, Meissner F, Beyer A, Hasson D, Crary JF, Schafer DP, Holtzman DM, Goate AM, Tarakhovsky A, Schaefer A.   +35 more
europepmc   +1 more source

Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain

, 2020
Jeremy C. Burns, Bunny Cotleur, Dirk Walther, Bekim Bajrami, Stephen Rubino, Ru Wei, Nathalie Franchimont, Susan L. Cotman, Richard M. Ransohoff, Michaël Mingueneau   +9 more
openalex   +1 more source

Alpinetin Nanoparticles Alleviate Optic Nerve Injury Induced by Acute Glaucoma via LRP1‐PPARγ Mediated Regulation of Microglial Lipid Metabolism

Advanced Science, EarlyView.
Microglial lipid metabolic dysfunction drives neurodegeneration in glaucoma. We found loss of LRP1 causes lipid accumulation and inflammation. We developed alpinetin‐loaded nanoparticles (AlpNPs) that bind LRP1, activate the PPARγ‐LXRα‐ABCA1 pathway to restore lipid homeostasis, promote an anti‐inflammatory phenotype, and protect retinal ganglion cells,
Miao Wei, Yujia Huo, Jingchang Yuan, Xiao Fan, Xiaochen Wang, Sisi Tan, Xi Gao, Ruotong Ouyang, Hong Li   +8 more
wiley   +1 more source

Sex differences in phenotypic modulation of microglia by early-life physical stress in a rat model of chronic primary low back pain. [PDF]

Pflugers Arch
Singhal D, Husk JR, Greffrath W, Treede RD.   +3 more
europepmc   +1 more source

Rev-erbs and glia—implications for neurodegenerative diseases [PDF]

, 2019
Dimitry, Julie M., Griffin, Percy, Musiek, Erik S.   +2 more
core   +1 more source