Results 51 to 60 of about 42,496 (156)
Essential factors for incompatible DNA end joining at chromosomal DNA double strand breaks in vivo. [PDF]
PLoS ONE, 2011 Non-homologous end joining (NHEJ) is a major pathway for the repair of DNA double strand break (DSBs) with incompatible DNA ends, which are often generated by ionizing irradiation.
Hideaki Ogiwara, Takashi Kohno
doaj +1 more source
BRCA1 Facilitates Microhomology-mediated End Joining of DNA Double Strand Breaks [PDF]
Journal of Biological Chemistry, 2002 BRCA1 is critical for the maintenance of genomic stability, in part through its interaction with the Rad50.Mre11.Nbs1 complex, which occupies a central role in DNA double strand break repair mediated by nonhomologous end joining (NHEJ) and homologous recombination. BRCA1 has been shown to be required for homology-directed recombination repair. However,
Qing, Zhong +3 more
openaire +2 more sources
Microhomology-assisted scarless genome editing in human iPSCs
Nature Communications, 2018 Positive selection for gene targeting is a common and reliable method to generate isogenic disease models in human pluripotent stem cells. Here, the authors present engineered selection markers which achieve scarless excision by CRISPR-Cas9 and ...
Shin-Il Kim +10 more
doaj +1 more source
CtIP promotes microhomology-mediated alternative end joining during class-switch recombination [PDF]
Nature Structural & Molecular Biology, 2010 Immunoglobulin heavy chain (Igh locus) class-switch recombination (CSR) requires targeted introduction of DNA double strand breaks (DSBs) into repetitive 'switch'-region DNA elements in the Igh locus and subsequent ligation between distal DSBs. Both canonical nonhomologous end joining (C-NHEJ) that seals DNA ends with little or no homology and a poorly
Lee-Theilen, Mieun +4 more
openaire +2 more sources
Requirement of POL3 and POL4 on non-homologous and microhomology-mediated end joining in rad50/xrs2 mutants of Saccharomyces cerevisiae [PDF]
, 2015 Non-homologous end joining (NHEJ) directly joins two broken DNA ends without sequence homology. A distinct pathway called microhomology-mediated end joining (MMEJ) relies on a few base pairs of homology between the recombined DNA.
Schiestl, Robert H +4 more
core +1 more source
Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions [PDF]
Nucleic Acids Research, 2010 Ku or DNA ligase 4-independent alternative end joining (alt-EJ) repair of DNA double-strand breaks (DSBs) frequently correlates with increased junctional microhomology. However, alt-EJ also produces junctions without microhomology (apparent blunt joins), and the exact role of microhomology in both alt-EJ and classical non-homologous end joining (NHEJ ...
Yu, Amy Marie, McVey, Mitch
openaire +2 more sources
, 2022 Predictive TMEJ code for analyzing genomic loci. Code employed in Stroik et al (under review) - Stepwise requirements for Polymerases δ and θ in Theta-mediated end joining.
aluthman
core +1 more source
, 2005 Class switch recombination (CSR) is a region-specific, transcriptionally regulated, nonhomologous recombinational process that is initiated by activation-induced cytidine deaminase (AID).
Lennart Hammarström +16 more
core +1 more source
Frontiers in Genetics, 2021 Background: Emery–Dreifuss muscular dystrophy (EDMD) is a rare disease characterized by early joint contractures, slowly progressive muscular dystrophy, and cardiac involvement, which includes arrhythmia, dilated cardiomyopathy, hypertrophic ...
Danyu Song +5 more
doaj +1 more source
Stitching up broken DNA ends by FANCA
Molecular & Cellular Oncology, 2018 RAD52 rejoins resected broken DNA ends by mediating single-strand annealing. Our recent work elucidates that FANCA, a Fanconi anemia protein, also directly repairs double-strand breaks (DSBs) by catalyzing annealing of single-stranded DNA.
Anna Palovcak +3 more
doaj +1 more source